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vrijdag 10 november 2017

The Lancet: [Articles] Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, contr...

[Articles] Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2)
In critically ill adults with shock, early isocaloric enteral nutrition did not reduce mortality or the risk of secondary infections but was associated with a greater risk of digestive complications compared with early isocaloric parenteral nutrition.
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[Articles] Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial
Among post-menopausal women with severe osteoporosis, the risk of new vertebral and clinical fractures is significantly lower in patients receiving teriparatide than in those receiving risedronate.
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[Department of Error] Department of Error
Kingston A, Wohland P, Wittenberg R, et al. Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS). Lancet 2017; 390: 1676–84—In this Article (published online first on Aug 15, 2017), in the last sentence of the Methods paragraph within the Summary, the population projections should be for the UK and not for England, and should read as "…the proportions in each dependency state (by age group and sex) were applied to the 2014 UK population projections".
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[Comment] Prevention of fractures in patients with osteoporosis
Patients with osteoporosis who have previously had fragility fractures have the highest risk of recurrent fractures, and 10–20% of those with recent fractures will re-fracture within just 2 years.1 Yet most patients who have had fractures are untreated and those who are tend to be treated conservatively, namely with an oral bisphosphonate.2 Antiresorptive drugs, such as bisphosphonates and denosumab, and bone-forming agents, such as teriparatide, both increase bone mineral mass and reduce fragility fractures in patients with osteoporosis.
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[Department of Error] Department of Error
Kande Betu Ku Mesu V, Mutombo Kalonji W, Bardonneau C, et al. Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial. Lancet 2017; published online Nov 4, 2017. http://dx.doi.org/10.1016/S0140-6736(17)32758-7—In this Article, the route of administration of nifurtimox eflornithine combination therapy was corrected in the Background section in the Summary. This has been corrected as of Nov 9, 2017.
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