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dinsdag 14 november 2017

Nature Reviews Genetics Contents December 2017 Volume 18 Number 12 pp 701-760

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Nature Reviews Genetics
 

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TABLE OF CONTENTS
 
December 2017 Volume 18 Number 12 Advertisement
 
Nature Reviews Genetics cover
2016 2-year Impact Factor 40.282 Journal Metrics 2-year Median 28.5
In this issue
Research Highlights
Reviews
Analysis
Perspectives

 
Also this month
Article series:
Study designs
Disease mechanisms
 Featured article:
Beyond editing to writing large genomes
Raj Chari & George M. Church

 


A new open access journal dedicated to publishing the most important scientific advances in all aspects of genomics and its application in the practice of medicine.

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Nature Outlook: Women’s health 

From common diseases that affect the sexes differently to conditions that affect only women — and from birth, through the menopause, to old age — there are many challenges in women’s health.

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RESEARCH HIGHLIGHTS
 
Top

Gene expression: Principles of gene regulation across tissues
p701 | doi:10.1038/nrg.2017.94
PDF


Genetic variation: Birds of a feather — genetic mapping of yellow pigmentation
p702 | doi:10.1038/nrg.2017.87
PDF


Transcription: Intragenic enhancers dampen gene expression
p702 | doi:10.1038/nrg.2017.90
PDF


Cancer genomics: The driving force of cancer evolution
p703 | doi:10.1038/nrg.2017.95
PDF


Genetic engineering: On the road to efficient gene drives
p704 | doi:10.1038/nrg.2017.91
PDF


Transcription: Promoters dictate termination mode
p704 | doi:10.1038/nrg.2017.93
PDF


 

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REVIEWS
 
Top
Demographic history, selection and functional diversity of the canine genome
Elaine A. Ostrander, Robert K. Wayne, Adam H. Freedman & Brian W. Davis

p705 | doi:10.1038/nrg.2017.67
Despite being a single species, dogs represent nearly 400 breeds with substantial genetic, morphological and behavioural diversity. In this Review, Ostrander et al. discuss how genomics studies of dogs have enhanced our understanding of dog and human population history, the desired and unintended consequences of trait-based selective breeding, and potentially human-applicable insights into cancer, ageing, behaviour and neurological diseases.
Abstract | Full Text | PDF

 
Population genetics of sexual conflict in the genomic era
Judith E. Mank

p721 | doi:10.1038/nrg.2017.83
Sexual conflict is thought to increase population genetic diversity though balancing selection, which has important evolutionary implications. This Review discusses how population genomic approaches are contributing to a deeper understanding of sexual conflict and how it is resolved.
Abstract | Full Text | PDF

 
 
ANALYSIS
 
Top
Article series: Disease mechanisms
Convergence between biological, behavioural and genetic determinants of obesity
Sujoy Ghosh & Claude Bouchard

p731 | doi:10.1038/nrg.2017.72
Recent large-scale genome-wide association studies have identified numerous variants that are associated with obesity-relevant traits such as body mass index or body fat percentage. Here, the authors explore to what extent this genomic evidence matches the evidence from functional and mechanistic studies.
Abstract | Full Text | PDF | Supplementary information
 
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Nature Reviews Collection — The obesity epidemic: molecular and clinical considerations 

This collection of articles describes the latest efforts to understand the molecular mechanisms underlying obesity against a complex backdrop of factors that include socioeconomic status, environment and personal behaviour, as well as advances in treatment. 

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PERSPECTIVES
 
Top
OPINION
Article series: Study designs
Beyond editing to writing large genomes
Raj Chari & George M. Church

p749 | doi:10.1038/nrg.2017.59
Advances in genome sequencing, editing and synthetic biology have enhanced the feasibility of large-scale genome engineering, termed genome writing. In this Opinion article, Chari and Church discuss the strengths and limitations of diverse strategies for genome writing, including extensively modifying existing genomes versus synthesizing genomes de novo, and they provide future visions for writing large genomes.
Abstract | Full Text | PDF

 
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