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dinsdag 14 november 2017

Nature Biotechnology Contents: Volume 35 pp 993 - 1112

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TABLE OF CONTENTS

November 2017 Volume 35, Issue 11

In This Issue
Editorial
News
Correction
Opinion and Comment
Features
News and Views
Research
Careers and Recruitment

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In This Issue

Top

In this issue   ppvii - vii
Kathy Aschheim, Michael Francisco and Andrew Marshall
doi:10.1038/nbt.4019

Editorial

Top

Humans 2.0   p993
doi:10.1038/nbt.4018
Of the germline engineering approaches, mitochondrial replacement, rather than gene editing, is poised to have the greatest impact on our lives.

News

Top

With Alnylam's amyloidosis success, RNAi approval hopes soar   pp995 - 997
Cormac Sheridan
doi:10.1038/nbt1117-995

RET-oncogene-targeting drugs draw notice   p996
doi:10.1038/nbt1117-996

First AAV gene therapy poised for landmark approval   pp998 - 999
Eric Smalley
doi:10.1038/nbt1117-998

Duchenne drug clings on for FDA nod   p999
doi:10.1038/nbt1117-999

Age-related macular degeneration foils drugmakers   pp1000 - 1001
Elie Dolgin
doi:10.1038/nbt1117-1000

Allergan's Mohawk evergreening patent deal draws criticism, but ultimately may flop   p1002
Eva von Schaper
doi:10.1038/nbt1117-1002

Spanish group defeats Shkreli in Chagas voucher race   p1003
Lisa Melton
doi:10.1038/nbt1117-1003

Podcast

First rounders: Stelios Papadopoulos   p1004
doi:10.1038/nbt.3995

Around the world in a month   p1004
doi:10.1038/nbt1117-1004

Correction

Top

Corrections   p1004
doi:10.1038/nbt1117-1004c

Faster, Simpler Biological LC-MS/MS Analysis

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News

Top
Data Page

3Q17—Funding and partnership into overdrive   p1005
Laura DeFrancesco
doi:10.1038/nbt.4012

News Features

Better beings?   pp1006 - 1011
Amber Dance
doi:10.1038/nbt.3998
As the technology to create genetically modified babies moves closer to practice, what questions should we ask before such procedures are contemplated? Amber Dance investigates.

When replacement becomes reversion   pp1012 - 1015
Steve Connor
doi:10.1038/nbt.3996
Mitochondrial replacement therapy is being touted as a means of combating maternally inherited disease. But concerns are growing about mitochondrial reversion compromising cures. Steve Connor investigates.

Reproducing with DNA   pp1016 - 1020
Malorye Allison Branca
doi:10.1038/nbt.4002
Finding partners through DNA profiles has yet to catch on, but the commercial sector for preconception and prenatal testing is booming. Malorye Allison Branca reports.

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Opinion and Comment

Top
Correspondence

Public views on gene editing and its uses   pp1021 - 1023
George Gaskell, Imre Bard, Agnes Allansdottir, Rui Vieira da Cunha, Peter Eduard et al.
doi:10.1038/nbt.3958

Query the merits of embryo editing for reproductive research now   pp1023 - 1025
Insoo Hyun and Catherine Osborn
doi:10.1038/nbt.4000

MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets   pp1026 - 1028
Martin Steinegger and Johannes Soding
doi:10.1038/nbt.3988

Features

Top

Revisiting the Warnock rule   pp1029 - 1042
J Benjamin Hurlbut, Insoo Hyun, Aaron D Levine, Robin Lovell-Badge, Jeantine E Lunshof et al.
doi:10.1038/nbt.4015
Is it time to reassess the 14-day rule for human embryo research?

Patents

Recent patents related to germline modification   p1043
doi:10.1038/nbt.4013

News and Views

Top

Coiled coils unspring protein origami   pp1044 - 1045
Greg L Hura and John A Tainer
doi:10.1038/nbt.4003
Self-assembling sequences of protein coiled coils create polyhedral nanostructures for advanced applications in biomedicine, chemistry and materials science.

See also: Research by Ljubetic et al.

Engineered bacteria self-organize to sense pressure   pp1045 - 1047
Neydis Moreno Morales and Megan N McClean
doi:10.1038/nbt.3992
Bacteria are engineered with pattern-generating circuits to produce self-organized materials that can function as pressure sensors.

See also: Research by Cao et al.

The ecological landscape of microbiome science   pp1047 - 1049
Daryl M Gohl
doi:10.1038/nbt.3983
Two reports examine the sources of variation in methods for analyzing microbial communities.

See also: Research by Costea et al. | Research by Sinha et al.

Research Highlights   p1049
doi:10.1038/nbt.3999

Biotechnology
JOBS of the week
Assistant Professor (Tenure Track) of Food Biotechnology
ETH Zurich - The Swiss Federal Institute of Technology in Zurich
Faculty Position in Plant Biotechnology
MIT
Postdoc / Bioinformatician (m / f)
Heidelberg University
Geneticist for Scientific User Support (part-time)
INFRAFRONTIER GmbH
Postdoctoral Researcher position (research associate) in Systems Biomedicine (m / f)
University of Luxembourg
More Science jobs from
Biotechnology
EVENT
4th International Conference on Bioengineering and Biotechnology (ICBB'18)
August 19, 2018
Madrid, Spain
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Research

Top
Perspective

Ethical principles for the use of human cellular biotechnologies   pp1050 - 1058
Paul Root Wolpe, Karen S Rommelfanger and the Drafting and Reviewing Delegates of the BEINGS Working Groups: 
doi:10.1038/nbt.4007
A group of interdisciplinary delegates drawn from the top biotech-producing countries of the world offers a consensus statement outlining a set of principles important to consider in the ethical conversation about human cellular biotechnological research moving forward.

Review

Assisted reproductive technologies to prevent human mitochondrial disease transmission   pp1059 - 1068
Andy Greenfield, Peter Braude, Frances Flinter, Robin Lovell-Badge, Caroline Ogilvie et al.
doi:10.1038/nbt.3997
Replacement of pathogenic mitochondrial DNA in human embryos is poised for clinical application.

Analysis

Towards standards for human fecal sample processing in metagenomic studies   pp1069 - 1076
Paul I Costea, Georg Zeller, Shinichi Sunagawa, Eric Pelletier, Adriana Alberti et al.
doi:10.1038/nbt.3960
Testing 21 different fecal DNA extraction protocols in multiple laboratories results in a standardized protocol with the potential to improve comparability across human gut microbiome studies.

See also: News and Views by Gohl

Assessment of variation in microbial community amplicon sequencing by the Microbiome Quality Control (MBQC) project consortium   pp1077 - 1086
Rashmi Sinha, Galeb Abu-Ali, Emily Vogtmann, Anthony A Fodor, Boyu Ren et al.
doi:10.1038/nbt.3981
The Microbiome Quality Control project consortium reports outcomes of a baseline study (MBQC) that will guide future improvements in reproducibility of microbiome analyses.

See also: News and Views by Gohl

Articles

Programmable assembly of pressure sensors using pattern-forming bacteria   pp1087 - 1093
Yangxiaolu Cao, Yaying Feng, Marc D Ryser, Kui Zhu, Gregory Herschlag et al.
doi:10.1038/nbt.3978
Engineered bacteria self-assemble to generate structures that act as pressure sensors.

See also: News and Views by Morales & McClean

Design of coiled-coil protein-origami cages that self-assemble in vitro and in vivo    pp1094 - 1101
Ajasja Ljubetic, Fabio Lapenta, Helena Gradisar, Igor Drobnak, Jana Aupic et al.
doi:10.1038/nbt.3994
Protein origami using coiled-coil building blocks produces self-assembling polyhedral cages for diverse applications.

See also: News and Views by Hura & Tainer

Molecular afterglow imaging with bright, biodegradable polymer nanoparticles   pp1102 - 1110
Qingqing Miao, Chen Xie, Xu Zhen, Yan Lyu, Hongwei Duan et al.
doi:10.1038/nbt.3987
Ultra-high signal-to-background in vivo imaging is enabled by biocompatible semiconducting polymer nanoparticles.

Careers and Recruitment

Top

Third-quarter biotech job picture   p1111
Michael Francisco
doi:10.1038/nbt.4008

People

People   p1112
doi:10.1038/nbt.4014

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