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dinsdag 17 oktober 2017

The Lancet: [Comment] PML risk and natalizumab: the elephant in the room

[Comment] PML risk and natalizumab: the elephant in the room
Natalizumab is one of the most effective therapies currently available for relapsing-remitting multiple sclerosis.1 With the exception of rare hypersensitivity reactions, monthly intravenous infusions are well tolerated and, for most patients, treatment is not associated with an increase in infections.2 But, for unknown reasons, progressive multifocal leukoencephalopathy (PML), an opportunistic, disabling, and life-threatening disease caused by the John Cunningham virus (JCV), is associated with natalizumab treatment.
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[In Context] Facing up to brain injury
The Making Faces exhibition at the Royal Festival Hall is an art installation from Submit to Love Studios. This collective of self-taught artists is based at Headway East London, a charity that opened this studio as a rehabilitation programme for survivors of brain injuries over a decade ago. Since then, the programme has developed into a unique collective with a very distinct vocational and creative outlook. In conjunction with Headway East London, they have developed the Making Faces exhibition to depict and confront the physical and emotional aspects of constructing identity for survivors of brain injury.
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[In Context] Journey in an unknown country
In a garden, an old woman who has experienced a stroke approaches tentatively some snow on the ground. When prompted to define what she sees, at first she is unable to give it a name. Yet, when she takes some in her hand, the word "snow" suddenly materialises in her mind. The woman then tries to explain what is happening in her mind: "If I pick this…stuff up in my hand, then…I know its name. I didn't have to pick it up to know…what it was."
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[Corrections] Corrections
Terkelsen A J, Karlsson P, Lauria G, Freeman R, Finnerup N B, Jensen T S. The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes. Lancet Neurol 2017; 16: 934–44. The declaration of interests section of this article should have stated, "AJT has participated in an investigator-sponsored study provided by Sanofi Genzyme and Alynylam Pharmaceuticals." This correction has been made to the online version as of Oct 16, 2017.
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[In Context] The next generation of leaders advocating for brain health
A monologist, a musician, an event producer, and an animal behaviourist are working to change how society thinks about aging and dementia. These individuals are part of the first cohort of Atlantic Fellows at the Global Brain Health Institute and are using their talents to transform the way we think about and care for elders and people with dementia. Dana Smith investigates.
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