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donderdag 14 september 2017

The Lancet: [Comment] PARP inhibitors for targeted treatment in ovarian cancer

[Comment] PARP inhibitors for targeted treatment in ovarian cancer
Poly(ADP-ribose) polymerase (PARP) inhibitors emerged as the first targeted treatment for ovarian cancer, and are selectively active for women with mutations in BRCA1 and BRCA2 (mBRCA). On the basis of data showing activity (measured by the proportion of patients who achieved an objective response),1 the PARP inhibitor olaparib received US Food and Drug Administration (FDA) approval in 2014 specifically for women with germline mBRCA-associated (gBRCA) recurrent ovarian cancer.2 However, subsequent findings from clinical trials of PARP inhibitors have suggested that the importance of mBRCA as a predictive biomarker has diminished.
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[Perspectives] Ann Ashworth: pioneer in child nutrition
Ann Ashworth may have retired in 2005, but is still closely involved with work in the sphere in which she has made such a contribution over the past half century. She currently co-convenes an international malnutrition taskforce, which aims to build capacity to prevent and treat malnutrition and to highlight malnutrition as a major cause of child death. "Sub-Saharan Africa remains a major problem, but awareness has increased since the launch of the taskforce", she says.
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[Perspectives] Betty Kirkwood: trailblazer in global health epidemiology
After 38 years at the London School of Hygiene & Tropical Medicine (LSHTM), Betty Kirkwood is still in love with her academic home. "It's the mission—shared by everyone from cleaners to refectory staff to academic staff—to improve health worldwide that brings a unique atmosphere to the school", she says. Kirkwood is head of LSHTM's Maternal and Child Health Intervention Research Group, and has been Professor of Epidemiology and International Health at LSHTM since 1995.
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[Articles] The path to longer and healthier lives for all Africans by 2030: the Commission on the future of health in sub-Saharan Africa
Sub-Saharan Africa's health challenges are numerous and wide-ranging. Most sub-Saharan countries face a double burden of traditional, persisting health challenges, such as infectious diseases, malnutrition, and child and maternal mortality, and emerging challenges from an increasing prevalence of chronic conditions, mental health disorders, injuries, and health problems related to climate change and environmental degradation. Although there has been real progress on many health indicators, life expectancy and most population health indicators remain behind most low-income and middle-income countries in other parts of the world.
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[Correspondence] Response to an African-driven health agenda
There is no question that Africa faces a myriad of health challenges and The Lancet Editorial (July 8, p 96)1 captured it well in the statement that "health is much more than just health care," which reflects the absence of systems for health.
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