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dinsdag 1 augustus 2017

The EMBO Journal Table of Contents for 01 August 2017; Vol. 36, No. 15

http://embopress.org/collections
01 August 2017 | Volume 36, Number 15 Submit


Table of Contents

Commentary
News & Views
Review
Articles
COVER

Volume 36, Number 15



Commentary
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Mitochondrial replacement therapy aims to prevent the transmission of mitochondrial‐linked diseases by exchanging maternal mitochondria with healthy ones. To improve its safety and efficiency, it is vital to understand how and which mitochondrial genomes of the oocyte are tagged for replication in the growing embryo.

Don P Wolf, Tomonari Hayama, and Shoukhrat Mitalipov
Published online 05.07.2017

News & Views
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Notch ligand‐receptor interactions are promoted by ligand binding to membrane lipids, suggesting a new mode of Notch signaling regulation.

Ben‐Zion Shilo and David Sprinzak
Published online 14.07.2017

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The discovery of a stem cell‐specific Sin3a‐HDAC subunit required for self‐renewal suggests that chromatin modifying complexes may exist in a variety of cell type‐dependent forms.

Raphaël Pantier, Nicholas P Mullin, and Ian Chambers
Published online 28.06.2017

Review
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The metabolic and hypoxic signaling pathways acting in vascular endothelial cells, and impacting on conditions such as cancer and atherosclerosis, are the focus of this part of our Metabolism review series.

Brian W Wong, Elke Marsch, Lucas Treps, Myriam Baes, and Peter Carmeliet
Published online 21.06.2017

Articles
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Structural variability in the C2 domain of Notch ligands determines membrane binding and regulates Notch activation, a role that is lost in disease‐associated Jagged1 variants.

Richard J Suckling, Boguslawa Korona, Pat Whiteman, Chandramouli Chillakuri, Laurie Holt, Penny A Handford, and Susan M Lea
Published online 01.06.2017 Open Access

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Quantitative proteomics identifies an ES cell‐specific form of a chromatin repressor complex, which shapes the particular chromatin state required for proliferation and self‐renewal of these cells.

Gundula Streubel, Darren J Fitzpatrick, Giorgio Oliviero, Andrea Scelfo, Bruce Moran, Sudipto Das, Nayla Munawar, Ariane Watson, Kieran Wynne, Gian Luca Negri, Eugene T Dillon, SriGanesh Jammula, Karsten Hokamp, Darran P O'Connor, Diego Pasini, Gerard Cagney, and Adrian P Bracken
Published online 29.05.2017

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Restraint of the NRF2 antioxidant response in unstressed cells requires O‐GlcNAcylation of the cullin ligase adaptor KEAP1, and can be released by glucose deprivation.

Po‐Han Chen, Timothy J Smith, Jianli Wu, Priscila F Siesser, Brittany J Bisnett, Farhan Khan, Maxwell Hogue, Erik Soderblom, Flora Tang, Jeffrey R Marks, Michael B Major, Benjamin M Swarts, Michael Boyce, and Jen‐Tsan Chi
Published online 29.06.2017

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Co‐crystallization reveals how a cancer‐associated non‐cyclin activator induces an active Cdk2 conformation refractory to canonical cell cycle‐related regulatory mechanisms.

Denise A McGrath, Bre‐Anne Fifield, Aimee H Marceau, Sarvind Tripathi, Lisa A Porter, and Seth M Rubin
Published online 30.06.2017

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A novel histone variant‐specific interactor localizes to H2A.Z‐containing nucleosomes at start sites of highly transcribed genes, affecting gene expression profiles, cell division and organ development.

Sebastian Pünzeler, Stephanie Link, Gabriele Wagner, Eva C Keilhauer, Nina Kronbeck, Ramona MM Spitzer, Susanne Leidescher, Yolanda Markaki, Edith Mentele, Catherine Regnard, Katrin Schneider, Daisuke Takahashi, Masayuki Kusakabe, Chiara Vardabasso, Lisa M Zink, Tobias Straub, Emily Bernstein, Masahiko Harata, Heinrich Leonhardt, Matthias Mann, Ralph AW Rupp, and Sandra B Hake
Published online 23.06.2017

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Deletion of p21 in senescent cells leads to increased DNA damage response and NF‐κB/JNK/caspase‐mediated cell death in vitro as well as alleviated liver fibrosis in vivo.

Reut Yosef, Noam Pilpel, Nurit Papismadov, Hilah Gal, Yossi Ovadya, Ezra Vadai, Stav Miller, Ziv Porat, Shifra Ben‐Dor, and Valery Krizhanovsky
Published online 12.06.2017 Open Access

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CryoEM reveals that co‐chaperone ERdj3 displays an unusual tetramer organization, which is required for efficient substrate binding and for maintaining secretory proteostasis during ER stress.

Kai‐Chun Chen, Song Qu, Saikat Chowdhury, Isabelle C Noxon, Joseph D Schonhoft, Lars Plate, Evan T Powers, Jeffery W Kelly, Gabriel C Lander, and R Luke Wiseman
Published online 27.06.2017

 
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