We bring you the latest news from the healthcare about the health care in the United Kingdom. Do your have news for us? Contact the editor. Watch also this special movie.

donderdag 3 augustus 2017

Nature Structural & Molecular Biology Contents: 2017 Volume #24 pp 607 - 681

If you are unable to see the message below, click here to view.
Nature Structural & Molecular Biology

TABLE OF CONTENTS

August 2017 Volume 24, Issue 8

News and Views
Review
Articles
Advertisement
 
Call for Papers - Virology 

Nature Microbiology is now accepting submissions in Virology research. Have something in the pipeline? 

Submit your manuscript!


Subscribe
 
Facebook
 
RSS
 
Recommend to library
 
Twitter
 

Advertisement
HIV IMMUNITY AND ERADICATION,
A HERRENHAUSEN SYMPOSIUM


November 2-3, 2017 | Hanover, Germany

REGISTER NOW!
 

News and Views

Top

A tetrad of chromatin interactions for chromosome pairing in X inactivation   pp607 - 608
Ivan Krivega and Ann Dean
doi:10.1038/nsmb.3447
An unusual pairing of homologous X chromosomes occurs during X inactivation. A new study in mouse embryonic stem cells shows that telomeres and the telomeric RNA PAR-TERRA are responsible for additional pairwise interactions that guide Xic-Xic pairing.

See also: Article by Chu et al.

Dueling RNA-binding proteins promote translational activation   pp609 - 610
Paul Lasko
doi:10.1038/nsmb.3445
Meiotic progression is controlled by cytoplasmic polyadenylation and translational activation of masked, maternal mRNAs. RNA-binding-protein interactions with adjacent cis elements cause local conformational changes to the mRNAs that determine the extent and timing of their activation.

See also: Article by Weill et al.

Review

Two chaperones locked in an embrace: structure and function of the ribosome-associated complex RAC   pp611 - 619
Ying Zhang, Irmgard Sinning and Sabine Rospert
doi:10.1038/nsmb.3435
The ribosome-associated complex (RAC) is formed by the JD protein Zuo1 and the unconventional Hsp70 Ssz1. This Review presents recent developments that have increased our understanding of RAC's mechanisms and cellular functions.

Structural & Molecular Biology
JOBS of the week
2x Postdoc & 4x PhD Scholarchip in Plant Molecular Biology
Institute of Biochemistry and Biophysics, Polish Academy of Sciences
Chairs for Department of Biochemistry and Molecular Biology and Department of Immunology at Peking University
The Peking University Health Science Center
Open faculty positions for Institute of Molecular Biology, Academia Sinica
Institute of Molecular Biology, Academia Sinica
Assistant / Associate Professor
USC School of Pharmacy
Postdoctoral Fellowship in Natural and Physical Sciences
University of Missouri - Kansas City
More Science jobs from
Structural & Molecular Biology
EVENT
The 3rd Conference on Advances in Biochemistry and Molecular Biology (CABMB 2017)
01.12.17
Sanya, China
More science events from

Articles

Top

PAR-TERRA directs homologous sex chromosome pairing   pp620 - 631
Hsueh-Ping Chu, John E Froberg, Barry Kesner, Hyun Jung Oh, Fei Ji et al.
doi:10.1038/nsmb.3432
New analyses reveal that TERRA transcripts arising from the subtelomeric pseudoautosomal (PAR) region of sex chromosomes nucleate pairing of X alleles in mouse ES cells.

See also: News and Views by Krivega & Dean

Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease   pp632 - 642
Zhentao Zhang, Seong Su Kang, Xia Liu, Eun Hee Ahn, Zhaohui Zhang et al.
doi:10.1038/nsmb.3433
Asparagine endopeptidase (AEP) cleaves human α-synuclein at Asn103, yielding a fragment with higher aggregation propensity than that of the full-length protein. Truncated α-synuclein is also more neurotoxic and leads to dopaminergic neuronal loss and motor impairments in mice.

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses   pp643 - 651
Xiaoguang Xue, Jin Wu, Daniel Ricklin, Federico Forneris, Patrizia Di Crescenzio et al.
doi:10.1038/nsmb.3427
The structure of C3b in complex with factor I and a shortened version of factor H, along with functional analyses, leads to a mechanistic model for how regulators determine sequential cleavage events on C3b.

Mechanochemical evolution of the giant muscle protein titin as inferred from resurrected proteins   pp652 - 657
Aitor Manteca, Jorg Schonfelder, Alvaro Alonso-Caballero, Marie J Fertin, Nerea Barruetabeña et al.
doi:10.1038/nsmb.3426
Single-molecule spectroscopy analyses of titin fragments from modern animals and reconstructed from the last common ancestors to mammals, sauropsids and tetrapods shed light on the evolution of the mechanical properties of muscle titin from the Paleozoic to our days.

Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis   pp658 - 665
Christopher R Faehnle, Jack Walleshauser and Leemor Joshua-Tor
doi:10.1038/nsmb.3428
Structural analysis of the uridyl transferases TUT4 and TUT7 reveals the use of two functional modules in the switch from monouridylation of pre-let-7, which promotes let-7 expression, to oligouridylation of pre-let-7, which marks it for degradation.

A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer   pp666 - 671
Rosanna M Robertson, Jiangwei Yao, Stefan Gajewski, Gyanendra Kumar, Erik W Martin et al.
doi:10.1038/nsmb.3436
The crystal structure of Thermotoga maritima lysophosphatidic acid acyltransferase reveals a two-helix motif that positions the active site for catalysis within the membrane bilayer.

Musashi 1 regulates the timing and extent of meiotic mRNA translational activation by promoting the use of specific CPEs   pp672 - 681
Laure Weill, Eulàlia Belloc, Chiara Lara Castellazzi and Raúl Méndez
doi:10.1038/nsmb.3434
New data reveal how Musashi binding to Xenopus oocyte mRNAs promotes changes in RNA secondary structure that modulate CPEB1 binding and influence polyadenylation and translational efficiency.

See also: News and Views by Lasko

Top
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com
More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount
(You will need to log in to be recognised as a nature.com registrant)

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our customer feedback department

Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Springer Nature's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2017 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.

Springer Nature