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donderdag 17 augustus 2017

Nature Reviews Genetics Contents September 2017 Volume 18 Number 9 pp 513-575

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Nature Reviews Genetics


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An online-only, open access, multidisciplinary journal dedicated to publishing high-quality original research articles, reviews, editorials, commentaries, and hypothesis generating observations on all areas of breast cancer research. Part of the Nature Partner Journals series, published in partnership with the Breast Cancer Research Foundation. 

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TABLE OF CONTENTS
 
September 2017 Volume 18 Number 9
Nature Reviews Genetics cover
2016 2-year Impact Factor 40.282 Journal Metrics 2-year Median 28.5
In this issue
Research Highlights
Reviews

Also this month
Article series:
Epigenetics
 Featured article:
Exploiting induced and natural epigenetic variation for crop improvement
Nathan M. Springer & Robert J. Schmitz


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npj Precision Oncology is a new open access, online-only, peer-reviewed journal committed to publishing cutting-edge scientific research in all aspects of precision oncology from basic science to translational applications, to clinical medicine.

The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota.

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RESEARCH HIGHLIGHTS
Top

Epigenetics: Getting instructions from mum
p513 | doi:10.1038/nrg.2017.64
PDF


Genome organization: Tracking chromosomal conformation through the cell cycle
p514 | doi:10.1038/nrg.2017.62
PDF


Complex disease: From non-coding risk variant to biological mechanism in CAD
p514 | doi:10.1038/nrg.2017.66
PDF


Alternative splicing: A thermometer controlling gene expression
p515 | doi:10.1038/nrg.2017.61
PDF


Nature Reviews Genetics
JOBS of the week
Postdoctoral Position- Developmental Genetics, Cardiovascular Biology and Stroke: University of Calgary
University of Calgary
Faculty Position in Cellular Genetics
Wellcome Trust Sanger Institute
Director - Clinical Genomic Care
Sidra Medical and Research Centre
Postdoctoral Fellowships in Biomedical Science (Cancer Research)
Columbia University Medical Center
Assistant Professor of Oncology
McArdle Laboratory for Cancer Research, University of Wisconsin-Madison School of Medicine and Public Health
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EMBO | EMBL Symposium: Systems Genetics: From Genotypes to Molecular Phenotypes to Complex Traits
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npj Molecular Phenomics is an online-only, open access journal that provides a forum for cutting-edge scientific advances in the emerging field of phenomics, the study of the physical and chemical characteristics of an individual in quantitative terms.

Part of the Nature Partner Journals series, npj Molecular Phenomics is published in partnership with Fudan University. The journal is now open for submissions. 

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REVIEWS
Top
Article series: Epigenetics
TET-mediated active DNA demethylation: mechanism, function and beyond
Xiaoji Wu & Yi Zhang
p517 | doi:10.1038/nrg.2017.33
A key mode of regulating DNA methylation is through active demethylation driven by TET-mediated oxidation of 5-methylcytosine (5mC). This Review discusses our latest understanding of the mechanisms and regulation of active DNA demethylation, and the roles of active demethylation (and the oxidized 5mC intermediates) in gene regulation, genome stability, development and disease.
Abstract | Full Text | PDF

The impact of replication stress on replication dynamics and DNA damage in vertebrate cells
Hervé Técher, Stéphane Koundrioukoff, Alain Nicolas & Michelle Debatisse
p535 | doi:10.1038/nrg.2017.46
Recent studies have provided insights into the sources of endogenous replication stress, which can result in DNA damage, checkpoint activation and genome-wide replication fork slowing. The authors review established mechanisms involved in the replication stress response, and propose a new model that reconciles data gained from different cellular models.
Abstract | Full Text | PDF

Network propagation: a universal amplifier of genetic associations
Lenore Cowen, Trey Ideker, Benjamin J. Raphael & Roded Sharan
p551 | doi:10.1038/nrg.2017.38
Network propagation is based on the principle that genes underlying similar phenotypes are more likely to interact with each other. It is proving to be a powerful approach for extracting biological information from molecular networks that is relevant to human disease.
Abstract | Full Text | PDF

Article series: Epigenetics
Exploiting induced and natural epigenetic variation for crop improvement
Nathan M. Springer & Robert J. Schmitz
p563 | doi:10.1038/nrg.2017.45
To unlock the potential of epigenetic variation for crop improvement, it will be crucial to understand how epigenetic variation is established and how it is stably inherited across generations. Springer and Schmitz review these challenges, the different sources of epigenetic variation in plants, and how epigenome profiling and engineering could help to improve crops.
Abstract | Full Text | PDF

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