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donderdag 24 augustus 2017

Nature Reviews Cancer contents September 2017 Volume 17 Number 9 pp 509-569

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Nature Reviews Cancer
 

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TABLE OF CONTENTS
 
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Nature Reviews Cancer cover
2016 2-year Impact Factor 37.147 Journal Metrics 2-year Median 28
In this issue
Research Highlights
Reviews
Perspectives
 
Also this month
 Featured article:
Therapy-related myeloid neoplasms: when genetics and environment collide
Megan E. McNerney, Lucy A. Godley & Michelle M. Le Beau

 
 
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A community map of cancer immunity

Immunotherapy is influenced by a complex set of tumour, host and environmental factors. Such factors combine to characterise the immunological status — or cancer-immune set point — of an individual.

Collaborate with peers to update, evolve and improve the cancer-immune set point framework
 
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An online-only, open access, multidisciplinary journal dedicated to publishing high-quality original research articles, reviews, editorials, commentaries, and hypothesis generating observations on all areas of breast cancer research.

Part of the Nature Partner Journals series, published in partnership with the Breast Cancer Research Foundation. 

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RESEARCH HIGHLIGHTS
 
Top

Tumour evolution: Metastasis takes a different route
p509 | doi:10.1038/nrc.2017.70
A new study has looked at the evolutionary origins of lymphatic and distant metastases in human colorectal cancer and found that, in most cases, cancer spread to lymph nodes is not a precursor for seeding of cancer cells to other organs.
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Therapeutic resistance: Ironing it out
p510 | doi:10.1038/nrc.2017.71
Since mesenchymal-like properties in cancer cells are often associated with therapy resistance, Viswanathan et al. explored vulnerabilities of these cells. They identified an enzyme of the lipid peroxidase pathway, inhibition of which caused ferroptosis in a range of cancer types.
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Metastasis: Throwing oil into the flames
p510 | doi:10.1038/nrc.2017.76
Both obesity and systemic inflammation promote cancer progression, although how obesity-associated inflammation affects cancer metastasis is poorly understood. Quail et al. now show that obesity induces cytokines that stimulate lung neutrophilia in mice, thereby promoting breast cancer metastasis.
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Immunotherapy: Searching in the immune checkpoint black box
p511 | doi:10.1038/nrc.2017.75
Reporting in Nature, the team led by Haining has identified that deletion of Ptpn2, among other genes, in tumour cells makes them more susceptible to PD1 inhibitors.
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Cancer
JOBS of the week
Faculty Position in Cancer Immunology
Penn State College of Medicine / Penn State Milton S. Hershey Medical Center
Postdoctoral Fellowships in Biomedical Science (Cancer Research)
Columbia University Medical Center
Cancer and / or Glioma Stem Cell Biologist
Cornell University
Postdoctoral / Scientist Position in Cancer Immunology / Immunotherapy
Universitatsspital Basel
Associate Director, Joint Center For Cancer Precision Medicine (CCPM)
Dana-Farber Cancer Institute (DFCI)
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Cancer
EVENT
Quantitative Imaging Workshop XIV: Lung Cancer, COPD and Cardiovascular Disease
02.10.17
McLean, USA
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nature.com webcasts

Nature Research Custom presents a webcast on: HCS for Predictive Toxicology and in vitro Pathology Using Simple 3D Microtissues

Date: Wednesday, September 6, 2017
Time: 8AM PDT | 11AM EDT | 4PM BST | 5PM CEST

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REVIEWS
 
Top
Therapy-related myeloid neoplasms: when genetics and environment collide
Megan E. McNerney, Lucy A. Godley & Michelle M. Le Beau

p513 | doi:10.1038/nrc.2017.60
Therapy-related myeloid neoplasms occur as a late complication following chemotherapy and/or radiotherapy administered for a primary condition. In this Review, McNerney et al. discuss recent studies that have improved our understanding of the aetiology of this disease.
Abstract | Full Text | PDF

 
Targeting autophagy in cancer
Jean M. Mulcahy Levy, Christina G. Towers & Andrew Thorburn

p528 | doi:10.1038/nrc.2017.53
Autophagy is a process that delivers cytoplasmic components to lysosomes for degradation. This Review discusses clinical interventions to target autophagy in cancer and explains how understanding the context-dependent role of autophagy in cancer should dictate future clinical trial design.
Abstract | Full Text | PDF

 
Evolutionary biology of high-risk multiple myeloma
Charlotte Pawlyn & Gareth J. Morgan

p543 | doi:10.1038/nrc.2017.63
Understanding how high-risk multiple myeloma evolves from more therapeutically tractable stages is crucial for improving outcomes for patients. This Review discusses the evolution of high-risk disease, how it may be diagnosed and how this might improve treatment.
Abstract | Full Text | PDF

 
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nature.com webcasts

Nature Research Custom presents: Visualizing divisions and development in 3D

Date: Wednesday, August 30 2017
Time: 8AM PDT | 11AM EDT | 4PM BST | 5PM CEST 

The webcast will last for 60 minutes and there will be an opportunity to ask your questions during the live broadcast!

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PERSPECTIVES
 
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OPINION
Unravelling biology and shifting paradigms in cancer with single-cell sequencing
Timour Baslan & James Hicks

p557 | doi:10.1038/nrc.2017.58
In this Opinion article, Baslan and Hicks discuss how single-cell sequencing could be used to advance our understanding of tumour biology and genetics, in addition to translational applications in the clinic.
Abstract | Full Text | PDF

 
Corrigendum: Targeting neoantigens to augment antitumour immunity
Mark Yarchoan, Burles A. Johnson, III, Eric R. Lutz, Daniel A. Laheru & Elizabeth M. Jaffee

p569 | doi:10.1038/nrc.2017.74
Full Text | PDF
 
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