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woensdag 2 augustus 2017

Nature Communications - 02 August 2017

 
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Organocatalyzed synthesis of fluorinated poly(aryl thioethers) OPEN
Nathaniel H. Park, Gabriel dos Passos Gomes, Mareva Fevre, Gavin O. Jones, Igor V. Alabugin & James L. Hedrick

Fluorinated poly(aryl thioethers), unlike their poly(aryl ethers) counterparts, have received little attention despite excellent physical properties displayed by many polysulfides. Here the authors show a highly efficient route to fluorinated poly(aryl thioethers) via an organocatalyzed nucleophilic aromatic substitution of silyl-protected dithiols.

01 August 2017 | doi: 10.1038/s41467-017-00186-3
Polymer synthesis  Polymerization mechanisms 

Charge carrier localised in zero-dimensional (CH3NH3)3Bi2I9 clusters OPEN
Chengsheng Ni, Gordon Hedley, Julia Payne, Vladimir Svrcek, Calum McDonald, Lethy Krishnan Jagadamma, Paul Edwards, Robert Martin, Gunisha Jain, Darragh Carolan, Davide Mariotti, Paul Maguire, Ifor Samuel & John Irvine

Understanding the confinement and transport of excitons in low dimensional systems will aid the development of next generation photovoltaics. Via photophysical studies Ni et al. observe 'quantum cutting' in 0D metal-organic hybrid materials based on methylammonium bismuth halide (CH3NH3)3Bi2I9.

01 August 2017 | doi: 10.1038/s41467-017-00261-9
Nanophotonics and plasmonics  Optical materials and structures 

Robust spin correlations at high magnetic fields in the harmonic honeycomb iridates OPEN
K. A. Modic, B. J. Ramshaw, J. B. Betts, Nicholas P. Breznay, James G. Analytis, Ross D. McDonald & Arkady Shekhter

The complex antiferromagnetic orders observed in the honeycomb iridates prevent access to a spin-liquid ground state. Here the authors apply extremely high magnetic fields to destroy the antiferromagnetic order in γ-lithium iridate and reveal a bistable, strongly correlated spin state.

01 August 2017 | doi: 10.1038/s41467-017-00264-6
Magnetic properties and materials 

Structures and transport dynamics of a Campylobacter jejuni multidrug efflux pump OPEN
Chih-Chia Su, Linxiang Yin, Nitin Kumar, Lei Dai, Abhijith Radhakrishnan, Jani Reddy Bolla, Hsiang-Ting Lei, Tsung-Han Chou, Jared A. Delmar, Kanagalaghatta R. Rajashankar, Qijing Zhang, Yeon-Kyun Shin & Edward W. Yu

Multidrug efflux pumps significantly contribute for bacteria resistance to antibiotics. Here the authors present the structure of Campylobacter jejuni CmeB pump combined with functional FRET assays to propose a transport mechanism where each CmeB protomers is functionally independent from the trimer.

01 August 2017 | doi: 10.1038/s41467-017-00217-z
Single-molecule biophysics  Transporters  X-ray crystallography 

Seismological evidence for a localized mushy zone at the Earth’s inner core boundary OPEN
Dongdong Tian & Lianxing Wen

The existence of a mushy zone in the Earth’s inner core has been suggested, but has remained unproven. Here, the authors have discovered a 4–8 km thick mushy zone at the inner core boundary beneath the Okhotsk Sea, indicating that there may be more localized mushy zones at the inner core boundary.

01 August 2017 | doi: 10.1038/s41467-017-00229-9
Core processes  Seismology 

Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor OPEN
Dirk Roymans, Sarhad S Alnajjar, Michael B Battles, Panchan Sitthicharoenchai, Polina Furmanova-Hollenstein, Peter Rigaux, Joke Van den Berg, Leen Kwanten, Marcia Van Ginderen, Nick Verheyen, Luc Vranckx, Steffen Jaensch, Eric Arnoult, Richard Voorzaat, Jack M. Gallup, Alejandro Larios-Mora, Marjolein Crabbe, Dymphy Huntjens, Pierre Raboisson, Johannes P. Langedijk et al.

Respiratory syncytial virus causes lung infections in children, immunocompromised adults, and in the elderly. Here the authors show that a chemical inhibitor to a viral fusion protein is effective in reducing viral titre and ameliorating infection in rodents and neonatal lambs.

01 August 2017 | doi: 10.1038/s41467-017-00170-x
Antivirals  Pharmacokinetics  Respiratory tract diseases 

The ancestral flower of angiosperms and its early diversification OPEN
Hervé Sauquet, Maria von Balthazar, Susana Magallón, James A. Doyle, Peter K. Endress, Emily J. Bailes, Erica Barroso de Morais, Kester Bull-Hereñu, Laetitia Carrive, Marion Chartier, Guillaume Chomicki, Mario Coiro, Raphaël Cornette, Juliana H. L. El Ottra, Cyril Epicoco, Charles S. P. Foster, Florian Jabbour, Agathe Haevermans, Thomas Haevermans, Rebeca Hernández et al.

The fossil record of flowers is limited, necessitating other approaches to understanding floral evolution. Here, Sauquet and colleagues reconstruct the characteristics and diversification of ancient angiosperm flowers by combining models of flower evolution with an extensive database of extant floral traits.

01 August 2017 | doi: 10.1038/ncomms16047
Phylogenetics  Plant evolution 

Oropharyngeal mucosal transmission of Zika virus in rhesus macaques OPEN
Christina M. Newman, Dawn M. Dudley, Matthew T. Aliota, Andrea M. Weiler, Gabrielle L. Barry, Mariel S. Mohns, Meghan E. Breitbach, Laurel M. Stewart, Connor R. Buechler, Michael E. Graham, Jennifer Post, Nancy Schultz-Darken, Eric Peterson, Wendy Newton, Emma L. Mohr, Saverio Capuano, David H. O’Connor & Thomas C. Friedrich

Zika virus (ZIKV) is present in body fluids, including saliva, but transmission risk through mucosal contact is not well known. Here, the authors show that oropharyngeal mucosal infection of macaques with a high ZIKV dose results in viremia, but that transmission risk from saliva of infected animals is low.

01 August 2017 | doi: 10.1038/s41467-017-00246-8
Viral infection  Viral transmission 

A dsRNA virus with filamentous viral particles OPEN
Hengxia Jia, Kaili Dong, Lingling Zhou, Guoping Wang, Ni Hong, Daohong Jiang & Wenxing Xu

Viruses with double-stranded RNA (dsRNA) genomes form typically isometric particles or are capsid-less. Here, the authors identify a mycovirus with an eight-segmented dsRNA genome that forms exceptionally long filamentous particles and could represent an evolutionary link between ssRNA and dsRNA viruses.

01 August 2017 | doi: 10.1038/s41467-017-00237-9
Viral evolution  Virus structures 

Sorting at embryonic boundaries requires high heterotypic interfacial tension OPEN
Laura Canty, Eleyine Zarour, Leily Kashkooli, Paul François & François Fagotto

The mechanisms that cause different cells to segregate into distinct tissues are unclear. Here the authors show in Xenopus that formation of a boundary between two tissues is driven by local tension along the interface rather than by global differences in adhesion or cortical contractility.

31 July 2017 | doi: 10.1038/s41467-017-00146-x
Cell adhesion  Cell migration  Computational biophysics  Embryogenesis 

Crystal structure of a Pseudomonas malonate decarboxylase holoenzyme hetero-tetramer OPEN
Riyaz Maderbocus, Blanche L. Fields, Keith Hamilton, Shukun Luo, Timothy H. Tran, Lars E. P. Dietrich & Liang Tong

Some aerobic bacteria contain a biotin-independent malonate decarboxylase (MDC), which allows them to use malonate as the sole carbon source. Here, the authors present the crystal structure of a Pseudomonas MDC and give insights into its catalytic mechanism and function.

31 July 2017 | doi: 10.1038/s41467-017-00233-z
Enzymes  Microbiology  X-ray crystallography 

RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network OPEN
Kyeongkyu Kim, Kyungjin Boo, Young Suk Yu, Se Kyu Oh, Hyunkyung Kim, Yoon Jeon, Jinhyuk Bhin, Daehee Hwang, Keun Il Kim, Jun-Su Lee, Seung-Soon Im, Seul Gi Yoon, Il Yong Kim, Je Kyung Seong, Ho Lee, Sungsoon Fang & Sung Hee Baek

Hepatic steatosis development may result from dysregulation of lipid metabolism, which is finely tuned by several transcription factors including the PPAR family. Here Kim et al. show that the nuclear receptor RORα inhibits PPARγ-mediated transcriptional activity by interacting with HDAC3 and competing for the promoters of lipogenic genes.

31 July 2017 | doi: 10.1038/s41467-017-00215-1
Metabolic syndrome  Non-alcoholic fatty liver disease  Nuclear receptors 

Initial pulse of Siberian Traps sills as the trigger of the end-Permian mass extinction OPEN
S. D. Burgess, J. D. Muirhead & S. A. Bowring

Although the mass end-Permian extinction is linked to large igneous provinces, its trigger remains unclear. Here, the authors propose that the abrupt change from flood lavas to sills resulted in the heating of sediments and led to the release of large-scale greenhouse gases to drive the end-Permian extinction.

31 July 2017 | doi: 10.1038/s41467-017-00083-9
Geology  Natural hazards  Palaeoclimate  Volcanology 

Major agricultural changes required to mitigate phosphorus losses under climate change OPEN
M. C. Ockenden, M. J. Hollaway, K. J. Beven, A. L. Collins, R. Evans, P. D. Falloon, K. J. Forber, K. M. Hiscock, R. Kahana, C. J. A. Macleod, W. Tych, M. L. Villamizar, C. Wearing, P. J. A. Withers, J. G. Zhou, P. A. Barker, S. Burke, J. E. Freer, P. J. Johnes, M. A. Snell et al.

The impact of climate change on phosphorus (P) loss from land to water is unclear. Here, the authors use P flux data, climate simulations and P transfer models to show that only large scale agricultural change will limit the effect of climate change on average winter P loads in three catchments across the UK.

31 July 2017 | doi: 10.1038/s41467-017-00232-0
Climate-change adaptation  Element cycles  Environmental health  Hydrology 

High-T c superconductivity in undoped ThFeAsN OPEN
T. Shiroka, T. Shang, C. Wang, G.-H. Cao, I. Eremin, H.-R. Ott & J. Mesot

Exploring the interplay between the superconducting gap and the antiferromagnetic phase in Fe-based superconductors remains an open issue. Here, the authors show that Fermi-surface modifications by means of structural distortions and correlation effects are as important as doping in inducing superconductivity in undoped ThFeAsN.

31 July 2017 | doi: 10.1038/s41467-017-00185-4
Magnetic properties and materials  Superconducting properties and materials 

Ubiquitination of stalled ribosome triggers ribosome-associated quality control OPEN
Yoshitaka Matsuo, Ken Ikeuchi, Yasushi Saeki, Shintaro Iwasaki, Christian Schmidt, Tsuyoshi Udagawa, Fumiya Sato, Hikaru Tsuchiya, Thomas Becker, Keiji Tanaka, Nicholas T. Ingolia, Roland Beckmann & Toshifumi Inada

Several protein quality control mechanisms are in place to trigger the rapid degradation of aberrant polypeptides and mRNAs. Here the authors describe a mechanism of ribosome-mediated quality control that involves the ubiquitination of ribosomal proteins by the E3 ubiquitin ligase Hel2/RQT1.

31 July 2017 | doi: 10.1038/s41467-017-00188-1
Protein quality control  Ribosome  Ubiquitylation 

Electron ptychographic microscopy for three-dimensional imaging OPEN
Si Gao, Peng Wang, Fucai Zhang, Gerardo T. Martinez, Peter D. Nellist, Xiaoqing Pan & Angus I. Kirkland

Three-dimensional ptychographic imaging with electrons has remained a challenge because, unlike X-rays, electrons are easily scattered by atoms. Here, Gao et al. extend multi-slice methods to electrons in the multiple scattering regime, paving the way to nanometer-scale 3D structure determination with electrons.

31 July 2017 | doi: 10.1038/s41467-017-00150-1
Imaging techniques  Transmission electron microscopy 

First-order spatial coherence measurements in a thermalized two-dimensional photonic quantum gas OPEN
Tobias Damm, David Dung, Frank Vewinger, Martin Weitz & Julian Schmitt

Phase transitions in quantum matter are related to correlation effects and they can change the ordering of material. Here the authors measure the first-order spatial correlation and the de Broglie wavelength for both thermal and condensed form of a photonic Bose gas in a dye-filled optical microcavity.

31 July 2017 | doi: 10.1038/s41467-017-00270-8
Bose–Einstein condensates  Optical physics  Ultracold gases 

Genetic and neuronal mechanisms governing the sex-specific interaction between sleep and sexual behaviors in Drosophila  OPEN
Dandan Chen, Divya Sitaraman, Nan Chen, Xin Jin, Caihong Han, Jie Chen, Mengshi Sun, Bruce S. Baker, Michael N. Nitabach & Yufeng Pan

Genes and circuits involved in sleep and sexual arousal have been extensively studied in Drosophila. Here the authors identify the sex determination genes fruitless and doublesex, and a sex-specific P1-DN1 neuronal feedback that governs the interaction between these competing behaviors

28 July 2017 | doi: 10.1038/s41467-017-00087-5
Motivation  Neural circuits  Sexual dimorphism  Sleep 

Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia OPEN
Gero Knittel, Tim Rehkämper, Darya Korovkina, Paul Liedgens, Christian Fritz, Alessandro Torgovnick, Yussor Al-Baldawi, Mona Al-Maarri, Yupeng Cun, Oleg Fedorchenko, Arina Riabinska, Filippo Beleggia, Phuong-Hien Nguyen, F. Thomas Wunderlich, Monika Ortmann, Manuel Montesinos-Rongen, Eugen Tausch, Stephan Stilgenbauer, Lukas P. Frenzel, Marco Herling et al.

ATM and TP53 mutations are associated with poor prognosis in chronic lymphocytic leukaemia (CLL). Here the authors generate mouse models of Tp53- and Atm-defective CLL mimicking the high-risk form of human disease and show that Atm-deficient CLL is sensitive to PARP1 inhibition.

28 July 2017 | doi: 10.1038/s41467-017-00210-6
Chronic lymphocytic leukaemia  Genetic engineering  Targeted therapies 

Afferent specific role of NMDA receptors for the circuit integration of hippocampal neurogliaform cells OPEN
R. Chittajallu, J. C. Wester, M. T. Craig, E. Barksdale, X. Q. Yuan, G. Akgül, C. Fang, D. Collins, S. Hunt, K. A. Pelkey & C. J. McBain

Proper brain function depends on the correct assembly of excitatory and inhibitory neurons into neural circuits. Here the authors show that during early postnatal development in mice, NMDAR signaling via activity of long-range synaptic inputs onto neurogliaform cells is required for their appropriate integration into the hippocampal circuitry.

28 July 2017 | doi: 10.1038/s41467-017-00218-y
Neural circuits  Neuronal physiology  Synaptic plasticity 

Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells OPEN
Roshan L. Shrestha, Duccio Conti, Naoka Tamura, Dominique Braun, Revathy A. Ramalingam, Konstanty Cieslinski, Jonas Ries & Viji M. Draviam

Human chromosomes are captured along microtubule walls and then tethered to microtubule-ends through a multi-step end-on conversion process. Here the authors show that Aurora-B regulates end-on conversion in human cells and establish a late role for Astrin-SKAP complex in the end-on conversion process.

28 July 2017 | doi: 10.1038/s41467-017-00209-z
Chromosome segregation  Mitosis 

Carbon stocks and changes of dead organic matter in China's forests OPEN
Jianxiao Zhu, Huifeng Hu, Shengli Tao, Xiulian Chi, Peng Li, Lai Jiang, Chengjun Ji, Jiangling Zhu, Zhiyao Tang, Yude Pan, Richard A. Birdsey, Xinhua He & Jingyun Fang

Reliable estimates of the total forest carbon (C) pool are lacking due to insufficient information on dead organic matter (DOM). Here, the authors estimate that the current DOM C stock in China is 925 ± 54 Tg and that it grew by 6.7 ± 2.2 Tg C/yr over the past two decades primarily due to increasing forest area

28 July 2017 | doi: 10.1038/s41467-017-00207-1
Carbon cycle  Climate-change ecology  Forest ecology 

Into the Dynamics of a Supramolecular Polymer at Submolecular Resolution OPEN
Davide Bochicchio, Matteo Salvalaglio & Giovanni M. Pavan

Accessing the dynamics of soft self-assembled materials at high resolution is very difficult. Here the authors show atomistic and coarse-grained modelling combined with enhanced sampling to characterize the molecular mechanisms and kinetics of monomer exchange in synthetic supramolecular polymers.

27 July 2017 | doi: 10.1038/s41467-017-00189-0
Atomistic models  Coarse-grained models  Polymers  Self-assembly 

Slow conformational exchange and overall rocking motion in ubiquitin protein crystals OPEN
Vilius Kurauskas, Sergei A. Izmailov, Olga N. Rogacheva, Audrey Hessel, Isabel Ayala, Joyce Woodhouse, Anastasya Shilova, Yi Xue, Tairan Yuwen, Nicolas Coquelle, Jacques-Philippe Colletier, Nikolai R. Skrynnikov & Paul Schanda

X-ray crystallography is the main method for protein structure determination. Here the authors combine solid-state NMR measurements and molecular dynamics simulations and show that crystal packing alters the thermodynamics and kinetics of local conformational exchange as well as overall rocking motion of protein molecules in the crystal lattice.

27 July 2017 | doi: 10.1038/s41467-017-00165-8
Computational biophysics  Molecular modelling  Solid-state NMR  X-ray crystallography 

PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints OPEN
Saw-See Hong, Hubert Marotte, Guillaume Courbon, Gary S. Firestein, Pierre Boulanger & Pierre Miossec

Proliferation of synoviocytes contributes to joint damage in rheumatoid arthritis. Here the authors show that targeting of these cells by a vector, consisting of a baculovirus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a rat arthritis model.

27 July 2017 | doi: 10.1038/s41467-017-00142-1
Genetic vectors  Rheumatoid arthritis 

Thermally stable single atom Pt/m-Al2O3 for selective hydrogenation and CO oxidation OPEN
Zailei Zhang, Yihan Zhu, Hiroyuki Asakura, Bin Zhang, Jiaguang Zhang, Maoxiang Zhou, Yu Han, Tsunehiro Tanaka, Aiqin Wang, Tao Zhang & Ning Yan

Using precious noble elements as single atom metal catalysts is highly desirable and effective. Here the authors show the use of platinum atom catalysts anchored in mesoporous Al2O3 for selective hydrogenation and CO oxidation that have better stability and performance compared to their nanoparticle counterparts.

27 July 2017 | doi: 10.1038/ncomms16100
Heterogeneous catalysis  Sustainability 

Regulation of Drosophila hematopoietic sites by Activin-β from active sensory neurons OPEN
Kalpana Makhijani, Brandy Alexander, Deepti Rao, Sophia Petraki, Leire Herboso, Katelyn Kukar, Itrat Batool, Stephanie Wachner, Katrina S. Gold, Corinna Wong, Michael B. O’Connor & Katja Brückner

Hematopoietic sites in the Drosophila larva require the local peripheral nervous system for blood cells (hemocytes) to survive and proliferate, but how this is mediated is unclear. Here, the authors identify Activin-β from sensory neurons as signalling to hemocytes, affecting proliferation and adhesion.

27 July 2017 | doi: 10.1038/ncomms15990
Drosophila  Growth factor signalling  Peripheral nervous system 

Bayesian association scan reveals loci associated with human lifespan and linked biomarkers OPEN
Aaron F. McDaid, Peter K. Joshi, Eleonora Porcu, Andrea Komljenovic, Hao Li, Vincenzo Sorrentino, Maria Litovchenko, Roel P. J. Bevers, Sina Rüeger, Alexandre Reymond, Murielle Bochud, Bart Deplancke, Robert W. Williams, Marc Robinson-Rechavi, Fred Paccaud, Valentin Rousson, Johan Auwerx, James F. Wilson & Zoltán Kutalik

Along with various environmental factors, a complex genetic architecture influences human lifespan. Here, McDaid and colleagues reveal novel loci associated with human lifespan and linked biomarkers by Bayesian association scan.

27 July 2017 | doi: 10.1038/ncomms15842
Data integration  Genome-wide association studies  Statistical methods 

ATP-dependent modulation of MgtE in Mg2+ homeostasis OPEN
Atsuhiro Tomita, Mingfeng Zhang, Fei Jin, Wenhui Zhuang, Hironori Takeda, Tatsuro Maruyama, Masanori Osawa, Ken-ichi Hashimoto, Hisashi Kawasaki, Koichi Ito, Naoshi Dohmae, Ryuichiro Ishitani, Ichio Shimada, Zhiqiang Yan, Motoyuki Hattori & Osamu Nureki

MgtE is an Mg2+ transporter involved in Mg2+ homeostasis. Here, the authors report that ATP regulates the Mg+2-dependent gating of MgtE and use X-ray crystallography combined with functional studies to propose the molecular mechanisms involved in this process.

27 July 2017 | doi: 10.1038/s41467-017-00082-w
Ion channels  Membrane proteins  X-ray crystallography 

High-energy mid-infrared sub-cycle pulse synthesis from a parametric amplifier OPEN
Houkun Liang, Peter Krogen, Zhou Wang, Hyunwook Park, Tobias Kroh, Kevin Zawilski, Peter Schunemann, Jeffrey Moses, Louis F. DiMauro, Franz X. Kärtner & Kyung-Han Hong

Stable sub-cycle pulses in the mid-infrared region allow damage-free investigation of electron dynamics in solids. Here, the authors develop a suitable source to this end which is based on an optical parametric amplifier.

26 July 2017 | doi: 10.1038/s41467-017-00193-4
High-harmonic generation  Nonlinear optics  Ultrafast lasers 

A room temperature continuous-wave nanolaser using colloidal quantum wells OPEN
Zhili Yang, Matthew Pelton, Igor Fedin, Dmitri V. Talapin & Edo Waks

Colloidal nanocrystals are a promising material for easy-to-fabricate nanolasers, but suffer from high threshold powers. Here, the authors combine colloidal quantum wells with a photonic-crystal cavity into a stable, continuous-wave room-temperature nanolaser with a threshold below one microwatt

26 July 2017 | doi: 10.1038/s41467-017-00198-z
Nanoparticles  Semiconductor lasers 

Efficient probabilistic inference in generic neural networks trained with non-probabilistic feedback OPEN
A. Emin Orhan & Wei Ji Ma

Behavioural tasks often require probability distributions to be inferred about task specific variables. Here, the authors demonstrate that generic neural networks can be trained using a simple error-based learning rule to perform such probabilistic computations efficiently without any need for task specific operations.

26 July 2017 | doi: 10.1038/s41467-017-00181-8
Human behaviour  Network models  Neural encoding 

Coupled symmetric and asymmetric circuits underlying spatial orientation in fruit flies OPEN
Ta-Shun Su, Wan-Ju Lee, Yu-Chi Huang, Cheng-Te Wang & Chung-Chuan Lo

Ellipsoid body (EB) neurons in the fruit fly represent the animal heading through a bump-like activity dynamics. Here the authors report a connectome-driven spiking neural circuit model of the EB and the protocerebral bridge (PB) that can maintain and update an activity bump related to the spatial orientation.

26 July 2017 | doi: 10.1038/s41467-017-00191-6
Computational neuroscience  Navigation  Network models 

Non-aqueous selective synthesis of orthosilicic acid and its oligomers OPEN
Masayasu Igarashi, Tomohiro Matsumoto, Fujio Yagihashi, Hiroshi Yamashita, Takashi Ohhara, Takayasu Hanashima, Akiko Nakao, Taketo Moyoshi, Kazuhiko Sato & Shigeru Shimada

Orthosilicic acid is essential to many natural and synthetic materials but notoriously difficult to isolate, limiting its use in materials synthesis. Here, the authors successfully synthesize and stabilize orthosilicic acid and its oligomers, making available a new family of building blocks for silicon oxide-based materials.

26 July 2017 | doi: 10.1038/s41467-017-00168-5
Inorganic chemistry  Materials chemistry  Chemical synthesis 

Inference of neuronal functional circuitry with spike-triggered non-negative matrix factorization OPEN
Jian K. Liu, Helene M. Schreyer, Arno Onken, Fernando Rozenblit, Mohammad H. Khani, Vidhyasankar Krishnamoorthy, Stefano Panzeri & Tim Gollisch

How a neuron integrates sensory information requires knowledge about its functional presynaptic connections. Here the authors report a new method using non-negative matrix factorization to identify the layout of presynaptic bipolar cell inputs onto retinal ganglion cells and predict their responses to natural stimuli.

26 July 2017 | doi: 10.1038/s41467-017-00156-9
Neural circuits  Neural encoding  Retina 

Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth OPEN
Jinping Liu, Alex Kruswick, Hien Dang, Andy D. Tran, So Mee Kwon, Xin Wei Wang & Philipp Oberdoerffer

BRCA2 is essential for the repair of DNA damage; therefore, defects in BRCA2 are associated with tumorigenesis but also with increased susceptibility to genotoxic stress. Here the authors show that USP21 regulates the ability of tumor cells to repair damaged DNA by regulating BRCA2 stability.

26 July 2017 | doi: 10.1038/s41467-017-00206-2
Genomic instability  Hepatocellular carcinoma 

Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status OPEN
Iwo Kucinski, Michael Dinan, Golnar Kolahgar & Eugenia Piddini

Cell competition causes the removal of less fit cells (‘losers’) but why some gene mutations turn cells into losers is unclear. Here, the authors show that Drosophila wing disc cells carrying some loser mutations activate Nrf2 and JNK signalling, which contribute to the loser status.

26 July 2017 | doi: 10.1038/s41467-017-00145-y
Cell growth  Stress signalling 

The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways OPEN
Kun Zhang, Xiaohui Han, Zhen Zhang, Lina Zheng, Zhimei Hu, Qingbin Yao, Hongmei Cui, Guiming Shu, Maojie Si, Chan Li, Zhemin Shi, Ting Chen, Yawei Han, Yanan Chang, Zhi Yao, Tao Han & Wei Hong

Activated hepatic stellate cells are the principal contributors to liver fibrosis by secreting a variety of pro-fibrogenic cytokines . Here Zhang et al. demonstrate that a liver-enriched lncRNA, lnc-LFAR1, promotes liver fibrosis and HSC activation by activating TGFβ and Notch signaling.

26 July 2017 | doi: 10.1038/s41467-017-00204-4
Extracellular signalling molecules  Liver fibrosis  Long non-coding RNAs  Mechanisms of disease 

Environmentally stable interface of layered oxide cathodes for sodium-ion batteries OPEN
Shaohua Guo, Qi Li, Pan Liu, Mingwei Chen & Haoshen Zhou

The interface of layered cathodes for sodium ion batteries is subject to atmospheric and electrochemical corrosions. Here, the authors demonstrate an environmentally stable interface via titanium enriched surface reconstruction in a layered manganese-based oxide.

26 July 2017 | doi: 10.1038/s41467-017-00157-8
Batteries 

Anterior cingulate is a source of valence-specific information about value and uncertainty OPEN
Ilya E. Monosov

Rewards or punishments elicit diverse behavioral responses; however, the neural circuits underlying such flexibility are unclear. Here Monosov shows that this diversity could be supported by neurons in the anterior cingulate that represent expected value and uncertainty in a valence-specific manner.

26 July 2017 | doi: 10.1038/s41467-017-00072-y
Motivation  Prefrontal cortex 

AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination OPEN
Michael C. Haffner, David M. Esopi, Alcides Chaux, Meltem Gürel, Susmita Ghosh, Ajay M. Vaghasia, Harrison Tsai, Kunhwa Kim, Nicole Castagna, Hong Lam, Jessica Hicks, Nicolas Wyhs, Debika Biswal Shinohara, Paula J. Hurley, Brian W. Simons, Edward M. Schaeffer, Tamara L. Lotan, William B. Isaacs, George J. Netto, Angelo M. De Marzo et al.

Invasion of malignant cells involves changes in cytoskeleton dynamics. Here the authors identify absent in melanoma 1 as an actin binding protein and show that it regulates cytoskeletal remodeling and cell migration in prostate epithelial cells, acting as a metastatic suppressor in cancer cells.

26 July 2017 | doi: 10.1038/s41467-017-00084-8
Cell migration  Prostate cancer 
 
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  Latest ERRATA  
 
Erratum: Uniform electroactive fibre-like micelle nanowires for organic electronics OPEN
Xiaoyu Li, Piotr J. Wolanin, Liam R. MacFarlane, Robert L. Harniman, Jieshu Qian, Oliver E. C. Gould, Thomas G. Dane, John Rudin, Martin J. Cryan, Thomas Schmaltz, Holger Frauenrath, Mitchell A. Winnik, Charl F. J. Faul & Ian Manners
27 July 2017 | doi: 10.1038/ncomms16142
Conjugated polymers  Self-assembly 
 
  Latest CORRIGENDA  
 
Corrigendum: Controlling hybrid nonlinearities in transparent conducting oxides via two-colour excitation OPEN
M. Clerici, N. Kinsey, C. DeVault, J. Kim, E. G. Carnemolla, L. Caspani, A. Shaltout, D. Faccio, V. Shalaev, A. Boltasseva & M. Ferrera
01 August 2017 | doi: 10.1038/ncomms16139
Materials for optics  Nonlinear optics 
Corrigendum: Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming OPEN
Thomas Moreau, Amanda L. Evans, Louella Vasquez, Marloes R. Tijssen, Ying Yan, Matthew W. Trotter, Daniel Howard, Maria Colzani, Meera Arumugam, Wing Han Wu, Amanda Dalby, Riina Lampela, Guenaelle Bouet, Catherine M. Hobbs, Dean C. Pask, Holly Payne, Tatyana Ponomaryov, Alexander Brill, Nicole Soranzo, Willem H. Ouwehand et al.
28 July 2017 | doi: 10.1038/ncomms15076
 
 

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