We bring you the latest news from the healthcare about the health care in the United Kingdom. Do your have news for us? Contact the editor. Watch also this special movie.

dinsdag 8 augustus 2017

Nature Biotechnology Contents: Volume 35 pp 689 - 800

If you are unable to see the message below, click here to view.
Nature Biotechnology


Advertisement
World Congress on Animal Models in Drug Discovery and Development 
 
Charles River has proudly partnered with the EBD Group to provide the scientific program for this year's BioPharm America™ Conference. Be a part of this two-day conference that aims to bridge the gap between drug discovery and clinical application.

Register now>>
TABLE OF CONTENTS

August 2017 Volume 35, Issue 8

Editorial
News
Bioentrepreneur
Opinion and Comment
Feature
News and Views
Research
Careers and Recruitment

Advertisement
 
Technical Note: Simplify Production of Complex Proteins & Biologics

Producing high quality, functional proteins in a rapid and cost-effective manner can be challenging when dealing with complex or difficult-to-express proteins, particularly if cGMP-compliance is needed. Find out how implementing the right expression platform can transform your efforts.

Download article now


Subscribe
 
Facebook
 
RSS
 
Recommend to library
 
Twitter
 

Advertisement
Nature Outlook: Animal Health 

Animal and human health are closely linked. This Outlook examines how climate change is pushing diseases into formerly 'safe' regions of the world, the challenges in treating parasites, the efforts to vaccinate gorillas against Ebola and how a holistic approach to disease could further the well-being of animals. 

Access the Outlook free online

Produced with support from
Bayer Animal Health GmbH
 
Advertisement

BIOPHARMA DEALMAKERS
BIOPHARMA DEALMAKERSCompany Profiles and Partnering Opportunities


 
Advertisement
Nature Outlook: Food security

Adequate access to food is a universal right, but eliminating all forms of malnutrition in a growing world is no small task. In the coming decades significant improvements in how we produce, distribute and consume food will be required. 

Access the Outlook free online for six months >

Produced with support from: 
Nestlé
 
Advertisement
Nature Outline: Eardrum Regeneration

A burst eardrum is a common injury. Although ruptures can cause pain and hearing loss, most heal naturally. But for those that don’t, there could soon be an alternative to specialist surgery. Regenerative medicine is helping the eardrum to heal itself. 

Access the Outline free here > 

Produced with support from: 
Translational Research Informatics Center (TRI) 

Kitano Hospital 
 

Editorial

Top

Time for the data to speak   p689
doi:10.1038/nbt.3938
Retraction of a study claiming gene editing via an Argonaute enzyme illustrates the importance of post-publication peer review in the age of 24/7 media.

News

Top

First approval in sight for Novartis' CAR-T therapy after panel vote   pp691 - 693
Cormac Sheridan
doi:10.1038/nbt0817-691

LifeArc splashes out, fuelled by Keytruda   p693
doi:10.1038/nbt0817-693

Loxo TRK inhibitor data wows oncologists   pp694 - 695
Elie Dolgin
doi:10.1038/nbt0817-694

First new drug approval for AML in 15 years   pp696 - 698
Cormac Sheridan
doi:10.1038/nbt0817-696

Innovation drive seizes Indian biotech   p698
Killugudi Jayaraman
doi:10.1038/nbt0817-698

First multi-gene NGS diagnostic kit approved   p699
Mark Ratner
doi:10.1038/nbt0817-699

Plant breeders test drive first open-source seed bank   p700
Lucas Laursen
doi:10.1038/nbt0817-700

Google, Novartis back Medicxi's ambitions   p701
Melanie Senior
doi:10.1038/nbt0817-701

Around the world in a month   p702
doi:10.1038/nbt0817-702

Data Page

Drug pipeline 2Q17   p703
Laura DeFrancesco
doi:10.1038/nbt.3941

News Feature

Engineering the animal out of animal products   pp704 - 707
Amber Dance
doi:10.1038/nbt.3933
Amber Dance reports on a new wave of domestication[mdash]turning cells, rather than animals, into food.

Bringing Edman Back to Life 

Shimadzu's protein sequencers provide reliable, sensitive
N-terminal sequencing to researchers through automated Edman degradation. Software enables compliance with FDA 21 CFR Part 11 guidelines, while easy-to-use data analysis functions simplify operation, data processing and reporting.

Learn more.

Bioentrepreneur

Top
Data page

Research biotech patenting 2016   pp708 - 709
Brady Huggett and Kathryn Paisner
doi:10.1038/nbt.3829

Opinion and Comment

Top
Correspondence

Policy implications for post-Brexit biotech   pp710 - 711
John Annaloro and Tim K Mackey
doi:10.1038/nbt.3930

What the roll out of EU data legislation means for you   pp712 - 713
Rajam Neethu
doi:10.1038/nbt.3928

Ethical lessons from a tale of two genetically modified insects   pp713 - 716
Carolyn P Neuhaus and Arthur L Caplan
doi:10.1038/nbt.3927

Rules of the road for insect gene drive research and testing   pp716 - 718
Zach Adelman, Omar Akbari, John Bauer, Ethan Bier, Cinnamon Bloss et al.
doi:10.1038/nbt.3926

Feature

Top
Patents

Recent patents in synthetic biology   p719
doi:10.1038/nbt.3946

News and Views

Top

Big data opens a window onto wellness   pp720 - 721
Atul J Butte
doi:10.1038/nbt.3934
Longitudinal multi-omics data, clinical tests and biomarker analyses across a large cohort lay the groundwork for understanding the transition from wellness to disease.

See also: Research by Price et al.

Pluripotent stem cells that evade the immune radar   pp722 - 723
Steven C Kim and Andrew B Adams
doi:10.1038/nbt.3940
Human pluripotent stem cells are cloaked to evade immune rejection.

See also: Research by Gornalusse et al.

Turning silver dust into electronics   p723
Irene Jarchum
doi:10.1038/nbt.3939

Research Highlights   p724
doi:10.1038/nbt.3936

Research

Top
Perspective

Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea   pp 725 – 731
Robert M Bowers, Nikos C Kyrpides, Ramunas Stepanauskas, Miranda Harmon-Smith, Devin Doud et al.
doi:10.1038/nbt.3893
Standards for sequencing the microbial 'uncultivated majority', namely bacterial and archaeal single-cell genome sequences, and genome sequences from metagenomic datasets, are proposed.

Review

Characterization of noncoding regulatory DNA in the human genome   pp732 - 746
Ran Elkon and Reuven Agami
doi:10.1038/nbt.3863
Genome-wide mapping of regulatory elements will improve our understanding of how genetic variation in the noncoding genome affects disease phenotypes.

Articles

A wellness study of 108 individuals using personal, dense, dynamic data clouds   pp747 - 756
Nathan D Price, Andrew T Magis, John C Earls, Gustavo Glusman, Roie Levy et al.
doi:10.1038/nbt.3870
Longitudinal clinical and multi-omics data from 108 healthy individuals are analyzed to identify putative biomarkers and diagnostics of early disease states.

See also: News and Views by Butte

Nanoscale imaging of clinical specimens using pathology-optimized expansion microscopy   pp757 - 764
Yongxin Zhao, Octavian Bucur, Humayun Irshad, Fei Chen, Astrid Weins et al.
doi:10.1038/nbt.3892
Expansion microscopy, a technique for super-resolution imaging, is extended to clinical human tissue samples that are formalin fixed, paraffin embedded, stained and/or fresh frozen.

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells   pp765 - 772
German G Gornalusse, Roli K Hirata, Sarah E Funk, Laura Riolobos, Vanda S Lopes et al.
doi:10.1038/nbt.3860
Expression of the minimally polymorphic HLA-E molecule prevents NK-cell-mediated rejection of cells lacking expression of HLA-A, B and C.

See also: News and Views by Kim & Adams

Long time-lapse nanoscopy with spontaneously blinking membrane probes   pp773 - 780
Hideo Takakura, Yongdeng Zhang, Roman S Erdmann, Alexander D Thompson, Yu Lin et al.
doi:10.1038/nbt.3876
Super-resolution imaging of the dynamics of organelle structures in live cells is facilitated by blinking, far-red dyes.

Inference and quantification of peptidoforms in large sample cohorts by SWATH-MS   pp781 - 788
George Rosenberger, Yansheng Liu, Hannes L Rost, Christina Ludwig, Alfonso Buil et al.
doi:10.1038/nbt.3908
Detection of post-translational modifications by mass spectrometry is enhanced with an analytic method for data-independent acquisition proteomics.

Letters

Engineered Cpf1 variants with altered PAM specificities   pp789 - 792
Linyi Gao, David B T Cox, Winston X Yan, John C Manteiga, Martin W Schneider et al.
doi:10.1038/nbt.3900
The targeting range of the CRISPR endonuclease Cpf1 is increased three-fold by molecular engineering.

Rapid cloning of genes in hexaploid wheat using cultivar-specific long-range chromosome assembly   pp793 - 796
Anupriya Kaur Thind, Thomas Wicker, Hana Simkova, Dario Fossati, Odile Moullet et al.
doi:10.1038/nbt.3877
Rapid cloning of genes from any crop plant species (or cultivar) whose chromosomes can be flow sorted is enabled by a combination of short-read sequencing and proximity ligation.

Retraction

Retraction: DNA-guided genome editing using the Natronobacterium gregoryi Argonaute   p797
Feng Gao, Xiao Z Shen, Feng Jiang, Yongqiang Wu and Chunyu Han
doi:10.1038/nbt0817-797a

Errata

Erratum: Nature Biotechnology's academic spinouts of 2016   p797
Aaron Bouchie, Laura DeFrancesco, Cormac Sheridan and Sarah Webb
doi:10.1038/nbt0817-797b

Erratum: Making individualized drugs a reality   p797
Huub Schellekens, Mohammed Aldosari, Herre Talsma and Enrico Mastrobattista
doi:10.1038/nbt0817-797c

Erratum: Genome-wide target specificities of CRISPR RNA-guided programmable deaminases   p797
Daesik Kim, Kayeong Lim, Sang-Tae Kim, Sun-heui Yoon, Kyoungmi Kim et al.
doi:10.1038/nbt0817-797d

Careers and Recruitment

Top

Second-quarter biotech job picture   p798
Michael Francisco
doi:10.1038/nbt.3937

People

People   p800
doi:10.1038/nbt.3945

Advertisement
HIV IMMUNITY AND ERADICATION,
A HERRENHAUSEN SYMPOSIUM


November 2-3, 2017 | Hanover, Germany

REGISTER NOW!
 
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com
More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount
(You will need to log in to be recognised as a nature.com registrant)

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our customer feedback department

Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Springer Nature's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2017 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.

Springer Nature