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woensdag 19 juli 2017

Nature Reviews Nephrology - Table of Contents alert Volume 13 Issue 8

Nature Reviews Nephrology

 
TABLE OF CONTENTS
 
August 2017 Volume 13 Number 8
Nature Reviews Nephrology cover
2016 2-year Impact Factor 12.146 Journal Metrics 2-year Median 9
In this issue
Research Highlights
News and Views
Reviews

Also this month
 Featured article:
The 5-phosphatase OCRL in Lowe syndrome and Dent disease 2
Maria Antonietta De Matteis, Leopoldo Staiano, Francesco Emma & Olivier Devuyst


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RESEARCH HIGHLIGHTS
Top

Glomerular filtration rate: CKD risk factors are associated with increased single-nephron GFR
Published online: 26 June 2017
p443 | doi:10.1038/nrneph.2017.95

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Development: Pax2 keeps nephron progenitors on track
Published online: 12 June 2017
p444 | doi:10.1038/nrneph.2017.87

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Cystic kidney disease: A new osmoregulatory role for HNF-1β
Published online: 05 June 2017
p445 | doi:10.1038/nrneph.2017.81

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Podocyte biology: The podocyte adhesome
Published online: 12 June 2017
p445 | doi:10.1038/nrneph.2017.86

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Development: Tfcp2l1 drives Notch signalling and epithelial diversity in the collecting duct
Published online: 19 June 2017
p445 | doi:10.1038/nrneph.2017.93

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IN BRIEF

Transplantation: Survival benefit of accepting a diabetic deceased donor kidney | Onconephrology: New mouse model of clear cell renal cell carcinoma | Acute kidney injury: Targeting Treg cells to protect the kidney | Lupus nephritis: Role of NLRP3 inflammasomes in podocyte injury
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Nature Reviews Nephrology
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NEWS AND VIEWS
Top
Epidemiology: The global burden of reduced GFR: ESRD, CVD and mortality
Shilpa Sharma & Mark J. Sarnak
Published online: 19 June 2017
p447 | doi:10.1038/nrneph.2017.84
New data highlight the increasing global burden of cardiovascular disease, end-stage renal disease and disability adjusted life years that can be attributed to reduced glomerular filtration rate (GFR). These findings underline the need to evaluate whether screening for chronic kidney disease is effective and if early interventions can reduce the incidence of GFR-attributable adverse events.
Full Text | PDF

Vasculitis: A CLEAR argument for targeting complement in ANCA vasculitis
Ralph Kettritz
Published online: 22 May 2017
p448 | doi:10.1038/nrneph.2017.69
Mechanistic studies have implicated the alternative complement pathway, specifically C5a receptor activation, in the pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis. Results from a phase 2 trial suggest that C5a receptor blockade could enable the reduced use or complete withdrawal of steroids from induction protocols.
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Cardiovascular disease: PCSK9 inhibition: a new player in cholesterol-lowering therapies?
David Preiss & Colin Baigent
Published online: 03 July 2017
p450 | doi:10.1038/nrneph.2017.94
The FOURIER trial shows that evolocumab, an injectable monoclonal antibody against PCSK9, decreased the risk of cardiovascular events in high-risk patients receiving statin therapy. The beneficial effects of this drug were consistent with an absolute reduction in LDL cholesterol levels, although studies with a longer follow-up period are needed.
Full Text | PDF

Lupus nephritis: Mesenchymal stromal cells in lupus nephritis
Willem E. Fibbe & Ton J. Rabelink
Published online: 18 July 2017
p452 | doi:10.1038/nrneph.2017.100
Immunomodulatory treatment with mesenchymal stromal cells represents a novel therapeutic modality for immune-mediated kidney injury, including in the settings of renal transplantation and glomerulonephritis. A new study illustrates the complexity of aligning clinical trial design, manufacturing and availability of biomarkers in order to turn this promising concept into a therapeutic reality.
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REVIEWS
Top
The 5-phosphatase OCRL in Lowe syndrome and Dent disease 2
Maria Antonietta De Matteis, Leopoldo Staiano, Francesco Emma & Olivier Devuyst
Published online: 03 July 2017
p455 | doi:10.1038/nrneph.2017.83
Dysfunction of endolysosomal pathways can lead to generalized dysfunction of the proximal tubule. Here, De Matteis and colleagues describe the role of the inositol polyphosphate 5-phosphatase, OCRL, in the endolysosomal pathway and how mutations in the encoding gene lead to the clinical manifestations of Lowe syndrome and Dent disease 2.
Abstract | Full Text | PDF

The role of epigenetics in renal ageing
Paul G. Shiels, Dagmara McGuinness, Maria Eriksson, Jeroen P. Kooman & Peter Stenvinkel
Published online: 19 June 2017
p471 | doi:10.1038/nrneph.2017.78
Epigenetic factors control gene expression and activity in response to environmental perturbation and regulate ageing processes throughout the life course. Here, the authors discuss the epigenetic regulation of signalling pathways that modulate ageing and their impact on the kidney.
Abstract | Full Text | PDF

Redefining lupus nephritis: clinical implications of pathophysiologic subtypes
Feng Yu, Mark Haas, Richard Glassock & Ming-Hui Zhao
Published online: 03 July 2017
p483 | doi:10.1038/nrneph.2017.85
Current treatment recommendations for lupus nephritis are largely guided by the 2003 International Society of Nephrology/Renal Pathology Society classification system. Here, the authors discuss potential approaches by which this classification system could be improved through consideration of underlying disease processes characterized by the presence of glomerular crescents, podocyte injury, tubulointerstitial lesions and vascular injury.
Abstract | Full Text | PDF

Article series: Onconephrology
Targeted therapies for renal cell carcinoma
Edwin M. Posadas, Suwicha Limvorasak & Robert A. Figlin
Published online: 10 July 2017
p496 | doi:10.1038/nrneph.2017.82
This Review provides an overview of the molecular determinants of renal cell carcinoma, how understanding the underlying mechanisms of disease has fuelled the development of targeted therapies, and tools to assess the value of these agents.
Abstract | Full Text | PDF

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