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vrijdag 21 juli 2017

Nature Reviews Clinical Oncology - Table of Contents alert Volume 14 Issue 8

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Nature Reviews Clinical Oncology


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TABLE OF CONTENTS
 
August 2017 Volume 14 Number 8Advertisement
Nature Reviews Clinical Oncology cover
2016 2-year Impact Factor 20.693 Journal Metrics 2-year Median 12
In this issue
Editorial
Comment
Research Highlights
News and Views
Reviews
Perspectives

Also this month
 Featured article:
Targeted agents and immunotherapies: optimizing outcomes in melanoma
Jason J. Luke, Keith T. Flaherty, Antoni Ribas & Georgina V. Long


The National Cancer Research Institute (NCRI) Cancer Conference is the largest annual cancer research conference in the UK, featuring ground-breaking research. The Conference brings together people at all career levels and is the ideal setting to discuss ideas and establish new collaborations with colleagues from around the world. Informative and interactive sessions cover the breadth of cancer research and we hope you will join us at this important meeting.

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EDITORIAL
Top
WIN to avoid the valley of death
Published online: 20 July 2017
p453 | doi:10.1038/nrclinonc.2017.113

Full Text | PDF

 
COMMENT
Top
Scientific advice — is drug repurposing missing a trick?
Pan Pantziarka
Published online: 23 May 2017
p455 | doi:10.1038/nrclinonc.2017.69

Scientific Advice meetings are a mechanism to improve communications between drug developers and regulators during the drug-development process. While standard practice for industry, the benefits provided by these meetings are under-utilised by academia. In the context of drug repurposing, can scientific advice, as part of a proposed new R&D tax credits scheme, help to unblock some of the obstacles in the way to clinical adoption?

Full Text | PDF

RESEARCH HIGHLIGHTS
Top

Targeted therapies: Defining the best-in-class in NSCLC
Published online: 27 June 2017
p457 | doi:10.1038/nrclinonc.2017.99

PDF


Lung Cancer: Frontline nivolumab — CheckMate 026 ends in stalemate
Published online: 20 July 2017
p458 | doi:10.1038/nrclinonc.2017.102

PDF


Targeted therapies: Lenvatinib SELECTs survival benefit
Published online: 11 July 2017
p458 | doi:10.1038/nrclinonc.2017.103

PDF


Immunotherapy: PD-1 blockade exploiting MMR deficiency
Published online: 27 June 2017
p459 | doi:10.1038/nrclinonc.2017.98

PDF


Haematological cancer: Feasible mutation-targeted therapy
Published online: 11 July 2017
p460 | doi:10.1038/nrclinonc.2017.108

PDF


Breast cancer: Olaparib improves PFS
Published online: 20 June 2017
p460 | doi:10.1038/nrclinonc.2017.93

PDF


Haematological cancer: Brentuximab vedotin — a new standard for cutaneous T-cell lymphoma
Published online: 20 June 2017
p460 | doi:10.1038/nrclinonc.2017.94

PDF



IN BRIEF

Breast cancer: Microenvironment mediates differential resistance | Immunotherapy: Neuropilin-1 is required for Treg stability | Haematological cancer: Genomic disruption of CD7 avoids fractricide
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Nature Reviews Clinical Oncology
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NEWS AND VIEWS
Top
Haematological cancer: Where are we now with the treatment of multiple myeloma?
Gareth J. Morgan & Leo Rasche
Published online: 13 June 2017
p461 | doi:10.1038/nrclinonc.2017.82
The current standard-of-care therapy for patients with multiple myeloma is autologous stem-cell transplantation; however, whether this approach should be enhanced or displaced by triplet combination therapy is the subject of ongoing debate. We discuss the latest trial that has attempted to address this question and the impact of transplantation and triplet therapy assessment and surrogate end points in future trial design.
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REVIEWS
Top
Targeted agents and immunotherapies: optimizing outcomes in melanoma
Jason J. Luke, Keith T. Flaherty, Antoni Ribas & Georgina V. Long
Published online: 04 April 2017
p463 | doi:10.1038/nrclinonc.2017.43
In less than a decade, the treatment landscape of metastatic melanoma has changed dramatically. Novel targeted agents and immunotherapies are revolutionizing patient outcomes, but the range of available drugs complicates clinical decision-making. Herein, the authors chart the therapeutic advances and review the current evidence that can be used to guide therapeutic decisions for individual patients with metastatic melanoma, highlighting knowledge gaps.
Abstract | Full Text | PDF

Charged-particle therapy in cancer: clinical uses and future perspectives
Marco Durante, Roberto Orecchia & Jay S. Loeffler
Published online: 14 March 2017
p483 | doi:10.1038/nrclinonc.2017.30
Conventional radiotherapy with X-rays is being replaced by radiotherapy with high-energy charged particles, an approach that better spares healthy tissue from radiation but is associated with higher costs. Evidence supporting the cost-effectiveness of either modality can only come from the results of randomized clinical trials. The authors of this Review discuss ongoing randomized trials of charged-particle therapies as well as aspects related to radiobiology, which need to be taken into account in order to fully exploit the therapeutic potential of charged particles.
Abstract | Full Text | PDF

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The NCRI Cancer Conference is the UK's largest cancer research meeting, bringing together a unique mix of people at all career levels to network, discuss ideas and establish new collaborations. Informative and interactive sessions cover the breadth of cancer research and we hope you will join us at this important meeting.
 
PERSPECTIVES
Top
OPINION
Early phase clinical trials of anticancer agents in children and adolescents — an ITCC perspective
Lucas Moreno et al.
Published online: 16 May 2017
p497 | doi:10.1038/nrclinonc.2017.59
Precision medicine has dramatically changed the landscape of drug development in oncology, but this paradigm shift remains to be adopted in early phase clinical trials of molecularly targeted agents and immunotherapeutic agents in children with cancer. The authors, members of the Innovative Therapies for Children with Cancer (ITCC) Consortium, describe trial design strategies to enable drugs with promising activity to progress rapidly to randomized studies and, therefore, substantially accelerate drug development for children and adolescents with cancer.
Abstract | Full Text | PDF | Supplementary information

OPINION
The need for multidisciplinarity in specialist training to optimize future patient care
Alison C. Tree et al.
Published online: 29 November 2016
p508 | doi:10.1038/nrclinonc.2016.185
A multidisciplinary approach is essential for the optimization of patient care in oncology, especially in the current landscape, in which standard-of-care approaches to cancer treatment are evolving towards highly targeted treatments, precise image guidance and personalized cancer therapy. Herein, the authors discuss current career development pathways for oncologists, suggesting strategies to improve clinical training and research, with specific emphasis on the involvement of trainees in multidisciplinary teams.
Abstract | Full Text | PDF

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Nature Reviews Clinical Oncology was previously published as Nature Clinical Practice Oncology.

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