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Nature Cell Biology contents: August 2017 Volume 19 Number 8, pp 875 - 1003

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TABLE OF CONTENTS

August 2017 Volume 19, Issue 8

Editorial
Review
News and Views
Articles
Letters
Corrigenda
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Editorial

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Journal metrics: what's in a number?   p875
doi:10.1038/ncb3589
Metrics of research assessment should be applied with judgment and clarity to avoid undermining scientific efforts.

Review

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Organelle biogenesis in the endoplasmic reticulum   pp876 - 882
Amit S. Joshi, Hong Zhang and William A. Prinz
doi:10.1038/ncb3579
In this Review, Prinz and co-authors discuss the role of the endoplasmic reticulum (ER) in the de novo generation of peroxisomes, lipid droplets and omegasomes, and how this requires subdomains with specific protein and lipid compositions.

News and Views

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CTCF fences make good neighbours   pp883 - 885
Ivan Krivega and Ann Dean
doi:10.1038/ncb3584
CCCTC-binding factor (CTCF) sites are enriched at the boundaries of topologically associated domains (TADs), but their function within TADs is unclear. Removal of sub-TAD CTCF sites adjacent to the α-globin enhancers is now shown to result in inappropriate activation of neighbouring genes. Intra-TAD enhancer insulation might be broadly important for tissue specificity of enhancers.

See also: Article by Hanssen et al.

Origin and regulation of a lung repair kit   pp885 - 886
Jichao Chen
doi:10.1038/ncb3585
The lung undergoes a striking repair process in response to severe injuries such as influenza infection. A study now demonstrates that associated stem/progenitor cells are heterogeneous in nature and comprise subpopulations dominated by hypoxia/Notch or Wnt signalling. Modulation of this heterogeneity in favour of functional repair may have therapeutic value.

See also: Article by Xi et al.

The skinny on obesity and cancer   pp887 - 888
Jaclyn Sceneay and Sandra S. McAllister
doi:10.1038/ncb3583
Obesity now rivals smoking as one of the leading preventable causes of cancer. Obesity-associated neutrophilia is now shown to enhance breast cancer metastasis and to be reversible through dietary modification and weight loss.

See also: Article by Quail et al.

A key HDAC6 dependency of ARID1A-mutated ovarian cancer   pp889 - 890
Lucia Altucci
doi:10.1038/ncb3588
Mutations in AT rich interactive domain 1A (ARID1A) are common in ovarian cancers. A study now shows that HDAC6 activity is required for survival of ovarian cancer cells bearing ARID1A mutations. HDAC6 inhibition selectively promotes apoptosis of ARID1A-inactivated cells, supporting the use of HDAC6 inhibition in the treatment of clear cell ovarian cancer.

See also: Article by Bitler et al.

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Articles

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Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF   pp891 - 903
Bo O. Zhou, Hua Yu, Rui Yue, Zhiyu Zhao, Jonathan J. Rios et al.
doi:10.1038/ncb3570
Zhou et al. demonstrate that bone marrow adipocytes, but not intraperitoneal adipocytes, express high levels of stem cell factor (SCF), which is essential for the regeneration of haematopoietic stem cells and haematopoiesis after irradiation.

Local lung hypoxia determines epithelial fate decisions during alveolar regeneration   pp904 - 914
Ying Xi, Thomas Kim, Alexis N. Brumwell, Ian H. Driver, Ying Wei et al.
doi:10.1038/ncb3580
Xi et al. show that after influenza infection, hypoxia drives Notch signalling to expand Krt5+ basal-like cells in the lung. On HIF1α loss, epithelial progenitors directly differentiate into alveolar type II cells and promote functional regeneration.

See also: News and Views by Chen

Dll4 and Notch signalling couples sprouting angiogenesis and artery formation   pp915 - 927
Mara E. Pitulescu, Inga Schmidt, Benedetto Daniele Giaimo, Tobiah Antoine, Frank Berkenfeld et al.
doi:10.1038/ncb3555
Pitulescu et al. and Hasan et al. show that Dll4–Notch signalling in endothelial tip cells regulates angiogenesis through control of artery formation, linking sprouting angiogenesis and artery formation.

See also: Article by Hasan et al.

Endothelial Notch signalling limits angiogenesis via control of artery formation   pp928 - 940
Sana S. Hasan, Roman Tsaryk, Martin Lange, Laura Wisniewski, John C. Moore et al.
doi:10.1038/ncb3574
Pitulescu et al. and Hasan et al. show that Dll4–Notch signalling in endothelial tip cells regulates angiogenesis through control of artery formation, linking sprouting angiogenesis and artery formation.

See also: Article by Pitulescu et al.

Budding yeast Wee1 distinguishes spindle pole bodies to guide their pattern of age-dependent segregation   pp941 - 951
Jette Lengefeld, Manuel Hotz, Meaghen Rollins, Kristin Baetz and Yves Barral
doi:10.1038/ncb3576
Lengefeld et al. reveal how yeast cells distinguish between newly synthesized and pre-existing spindle pole bodies to enable their asymmetric segregation, through a mechanism involving Swe1, Kin3 and NuA4.

Tissue-specific CTCF–cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo   pp952 - 961
Lars L. P. Hanssen, Mira T. Kassouf, A. Marieke  Oudelaar, Daniel Biggs, Chris Preece et al.
doi:10.1038/ncb3573
Hanssen et al. show that CTCF–cohesin binding sites at the α-globin gene cluster function as boundaries to restrict the interaction of enhancers with the flanking chromatin, thus preventing abnormal gene expression.

See also: News and Views by Krivega & Dean

ARID1A-mutated ovarian cancers depend on HDAC6 activity   pp962 - 973
Benjamin G. Bitler, Shuai Wu, Pyoung Hwa Park, Yang Hai, Katherine M. Aird et al.
doi:10.1038/ncb3582
Bitler et al. show that HDAC6 activity is essential for the survival of ovarian cancer cells carrying loss-of-function ARID1A mutation, thus representing a promising therapeutic target.

See also: News and Views by Altucci

Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF   pp974 - 987
Daniela F. Quail, Oakley C. Olson, Priya Bhardwaj, Logan A. Walsh, Leila Akkari et al.
doi:10.1038/ncb3578
Joyce and colleagues report that obesity promotes lung neutrophilia in mice, which in the presence of a primary breast tumour fosters metastasis to the lung in a manner dependent on GM-CSF and IL5.

See also: News and Views by Sceneay & McAllister

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Letters

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Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization   pp988 - 995
Shyi-Chyi Wang, Tricia Yu Feng Low, Yukako Nishimura, Laurent Gole, Weimiao Yu et al.
doi:10.1038/ncb3577
Studying polarity establishment in C. elegans zygotes, Wang et al. find, by imaging GFP-tagged proteins, that clusters of the PAR-3 polarity protein assemble in response to membrane tension created by actomyosin contractility.

Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation   pp996 - 1002
Kimberly C. Lin, Toshiro Moroishi, Zhipeng Meng, Han-Sol Jeong, Steven W. Plouffe et al.
doi:10.1038/ncb3581
Lin et al. find that stress-induced p38 MAPK activation leads to cytoplasmic relocation of the Hippo pathway nuclear transcription factor TEAD. TEAD relocation causes inhibition of YAP activity and suppresses YAP-driven cancer cell growth.

Corrigenda

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Corrigendum: Pramel7 mediates ground-state pluripotency through proteasomal–epigenetic combined pathways   p1003
Urs Graf, Elisa A. Casanova, Sarah Wyck, Damian Dalcher, Marco Gatti et al.
doi:10.1038/ncb3572

Corrigendum: Pulsatile cell-autonomous contractility drives compaction in the mouse embryo   p1003
Jean-Leon Maître, Ritsuya Niwayama, Hervé Turlier, Francois Nedelec and Takashi Hiiragi
doi:10.1038/ncb3587

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