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dinsdag 27 juni 2017

Nature Reviews Immunology Contents July 2017 Volume 17 Number 7 pp 401-460

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Nature Reviews Immunology


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TABLE OF CONTENTS
 
July 2017 Volume 17 Number 7Advertisement
Nature Reviews Immunology cover
2016 2-year Impact Factor 39.932 Journal Metrics 2-year Median 29
In this issue
Research Highlights
Reviews
Perspectives

Also this month
 Featured article:
Does niche competition determine the origin of tissue-resident macrophages?
Martin Guilliams & Charlotte L. Scott

 
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RESEARCH HIGHLIGHTS
Top

Regulatory T cells: Subset-specific suppression
p401 | doi:10.1038/nri.2017.68
T-bet+ regulatory T cells form a stable subset with specific suppressive activity towards T-bet+ effector T cells.

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Tumour Immunology: LAP targeting reduces tolerogenic cells in cancer
p402 | doi:10.1038/nri.2017.65
Anti-LAP antibodies show promising anticancer properties.

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Regulatory T cells: Keep your hair on
p402 | doi:10.1038/nri.2017.72
Regulatory T cells modulate the hair follicle regeneration cycle by inducing stem cell proliferation and differentiation.

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Germinal centres: An ephrin B1-based guidance system
p403 | doi:10.1038/nri.2017.71
Ephrin B1 controls T follicular helper cell residence and function in germinal centres.

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Antiviral immunity: IFNλ offers frontline protection
p404 | doi:10.1038/nri.2017.70
Lambda interferons have a non-redundant role in protecting airway epithelial cells from influenza A virus infection without inducing immunopathology.

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T cells: Staying alive with S1P
p404 | doi:10.1038/nri.2017.73
Sphingosine 1-phosphate promotes naive T cell survival by supporting their mitochondrial function.

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JOURNAL CLUB
Neuroendrocrine effects on autoimmunity

p405 | doi:10.1038/nri.2017.47
Anne Cooke discusses a 1989 paper by Don Mason and colleagues that described a role for adrenal corticosteroids in modulating autoimmune pathology.

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Nature Reviews Immunology
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REVIEWS
Top
The immunopathology of sepsis and potential therapeutic targets
Tom van der Poll, Frank L. van de Veerdonk, Brendon P. Scicluna & Mihai G. Netea
p407 | doi:10.1038/nri.2017.36
Sepsis — which is caused by a dysregulated host response to infection — is a life-threatening organ dysfunction. This Review describes the recent advances in our understanding of sepsis pathogenesis and discusses strategies for the development of successful therapies.
Abstract | Full Text | PDF

Altered B cell signalling in autoimmunity
David J. Rawlings, Genita Metzler, Michelle Wray-Dutra & Shaun W. Jackson
p421 | doi:10.1038/nri.2017.24
In this Review, the authors propose that disease-associated genetic variants modulate signalling downstream of B cell receptors, Toll-like receptors and cytokine receptors in B cells to drive autoimmune responses. This altered signalling favours a naive B cell repertoire that is skewed towards self-reactivity and promotes the peripheral activation of autoreactive B cell clones.
Abstract | Full Text | PDF

BACH transcription factors in innate and adaptive immunity
Kazuhiko Igarashi, Tomohiro Kurosaki & Rahul Roychoudhuri
p437 | doi:10.1038/nri.2017.26
The transcriptional repressors BTB and CNC homology 1 (BACH1) and BACH2 compete with transcriptional activators of the basic region leucine zipper (bZIP) family to control widespread functions of the innate and adaptive immune systems.
Abstract | Full Text | PDF

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Call for nominations: 2017 John Maddox Prize for Standing up for Science.

Recognising the work of individuals who promote science in the face of hostility. Winners will be announced at a reception in London, as well as in Nature, and will receive £2,000.

Closing date for nominations is 31st July 2017.

Click to learn more
 
PERSPECTIVES
Top
OPINION
Does niche competition determine the origin of tissue-resident macrophages?
Martin Guilliams & Charlotte L. Scott
p451 | doi:10.1038/nri.2017.42
In this Opinion article, the authors discuss the limitations of categorizing tissue-resident macrophages based on their ontogeny. Instead, they propose that competition for a limited number of tissue niches may serve as a better framework for understanding the origins and functions of tissue macrophages.
Abstract | Full Text | PDF

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