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vrijdag 23 juni 2017

Nature Reviews Cancer contents July 2017 Volume 17 Number 7 pp393-440

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Nature Reviews Cancer


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Discover What's Driving Tumor Cell Biology

Cancer cells reprogram their metabolism to generate the energy and building blocks they need to proliferate. Agilent Seahorse XF technology measures changes in both glycolytic and mitochondrial activity in real time, providing a window into the Warburg effect, substrate dependency, and other metabolic aspects of tumor cell biology.
 
TABLE OF CONTENTS
 
July 2017 Volume 17 Number 7Advertisement
Nature Reviews Cancer cover
2016 2-year Impact Factor 37.147 Journal Metrics 2-year Median 28
In this issue
Comment
Research Highlights
Reviews
Perspectives

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Article series:
Clinical insights
 Featured article:
Common pitfalls in preclinical cancer target validation
William G. Kaelin, Jr

 
Leukemia: Collection on Acute Myeloid Leukemia

AML is an area of focus for Leukemia and this collection brings together a number of recent key articles published in the journal. 

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Funded by a grant from Astex Pharmaceuticals, Inc. (a member of the Otsuka group)

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A community map of cancer immunity

Immunotherapy is influenced by a complex set of tumour, host and environmental factors. Such factors combine to characterise the immunological status — or cancer-immune set point — of an individual.

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Article series: Clinical insights
Comment: Melanoma: a global perspective
Raul Ossio, Rodrigo Roldán-Marín, Héctor Martínez-Said, David J. Adams & Carla Daniela Robles-Espinoza
p393 | doi:10.1038/nrc.2017.43
Most of our current knowledge of melanoma is derived from the study of patients from populations of European descent, for whom public health, sun protection initiatives and screening measures have appreciably decreased disease mortality. Notably, some melanoma subtypes that most commonly develop in other populations are not associated with exposure to ultraviolet (UV) light, suggesting a different disease aetiology. Further study of these subtypes is necessary to understand their risk factors and genomic architecture, and to tailor therapies and public health campaigns to benefit patients of all ethnic groups.
Abstract | Full Text | PDF | Supplementary information

RESEARCH HIGHLIGHTS
Top

Cancer models: Tailored mouse models
p395 | doi:10.1038/nrc.2017.45
To advance preclinical research, two groups have developed mouse models of metastatic colorectal cancer using the transplantation of engineered organoids.
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Tumour immunology: LAP targeting reduces tolerogenic cells in cancer
p396 | doi:10.1038/nrc.2017.46
Anti-LAP antibodies show promising anticancer properties.
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Immunotherapy: Macrophages steal the show
p396 | doi:10.1038/nrc.2017.47
Pittet and collaborators show that macrophages can remove anti-PD1 antibodies from T cells, blunting their response, whereas Weissman and colleagues demonstrate that macrophages also express PD1 on their surface, which impairs their phagocytic activity.
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Leukaemia: Unravelling the heterogeneity of cancer stem cells
p397 | doi:10.1038/nrc.2017.44
Giustacchini, Thongjuea, et al. have developed a method to sensitively detect somatic mutations and analyze whole transcriptomes of the same single cell. Application of this technique to chronic myeloid leukaemia (CML) patient samples revealed heterogeneous CML stem cell populations with likely roles in CML progression and resistance to therapy.
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IN BRIEF

Tumour metabolism: Losing that remaining fat | Cancer Models: Modeling clear cell renal cell carcinoma | Targeted therapies: Expanding the use of PARP inhibitors
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Cancer
JOBS of the week
Postdoctoral Position in Cancer Biology and / or Epigenetics
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NEW JOURNAL! The Annual Review of Cancer Biology, Volume 1 is now available online, and reviews a range of subjects in cancer research representing important and emerging areas in the field. Free online access to this journal is available for six months with access code: CAONL2017.

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REVIEWS
Top
Imaging of anticancer drug action in single cells
Miles A. Miller & Ralph Weissleder
p399 | doi:10.1038/nrc.2017.41
This Review summarizes developments in the imaging of in vivo anticancer drug action, with a focus on microscopy approaches at the single-cell level and translational lessons for the clinic.
Abstract | Full Text | PDF | Supplementary information

Transposable elements in cancer
Kathleen H. Burns
p415 | doi:10.1038/nrc.2017.35
Long interspersed element-1 (LINE-1) transposable elements are active in the human genome. In this Review, Burns describes how the retrotransposition activity of LINE-1 in cancer genomes can result in somatically acquired insertions that mark evolving tumour clones.
Abstract | Full Text | PDF

Turning the tide in myelodysplastic/myeloproliferative neoplasms
Michael W. N. Deininger, Jeffrey W. Tyner & Eric Solary
p425 | doi:10.1038/nrc.2017.40
This Review describes our current understanding of the relationship between genotype and phenotype in myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) and discusses how this knowledge could be used to inform strategies to develop more effective treatments and improve clinical success.
Abstract | Full Text | PDF | Supplementary information
 
PERSPECTIVES
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OPINION
Common pitfalls in preclinical cancer target validation
William G. Kaelin, Jr
p425 | doi:10.1038/nrc.2017.32
This Perspective discusses some of the causes of the robustness and reproducibility problem in preclinical cancer research and suggests solutions.
Abstract | Full Text | PDF

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