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Nature contents: 15 June 2017

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  journal cover  
Nature Volume 546 Issue 7658
 
This Week  
 
 
Editorials  
 
 
 
Empty rhetoric over data sharing slows science
Governments, funders and scientific communities must move beyond lip-service and commit to data-sharing practices and platforms.
Harmonize conflicting regulations for genetically engineered plants and animals
Researchers must seize the chance to inject scientific sense into US governance of modified crops and livestock.
Reassess dam building in the Amazon
Brazil and neighbouring nations need a transparent and integrated energy assessment centred on evidence.
 
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World View  
 
 
 
Let Trump claim a better deal on climate
If we can stomach it, a ‘renegotiation’ of the Paris Agreement could help us all, says Elliot Diringer.
 
Seven Days  
 
 
 
Plutonium accident, ancient amber and a call to climate scientists
The week in science: 9–15 June 2017.
Research Highlights  
 
 
 
This issue's Research Highlights
Selections from the scientific literature.
 
 
Advertising.
 
 
News in Focus
 
Eye-opening picture of fetal immune system emerges
Human fetuses have an immune system that acts differently from the adult version.
Heidi Ledford
UK scientists hope for softened Brexit after shock election result
Conservative party loses majority but aims to form government.
Elizabeth Gibney
United States revives space-policy council after 24-year absence
US vice-president to head group overseeing civilian and military space activities.
Alexandra Witze
US mental-health agency’s push for basic research has slashed support for clinical trials
Analysis reveals that the number of clinical trials funded by the National Institute of Mental Health has fallen by 45% since the agency began to focus on the biological roots of disease.
Sara Reardon
 
Bats are global reservoir for deadly coronaviruses
Finding could help researchers to better predict where these viruses are likely to make the jump from animals to people.
Amy Maxmen
Features  
 
 
 
The ‘time machine’ reconstructing ancient Venice’s social networks
Machine-learning project will analyse 1,000 years of maps and manuscripts from the floating city's golden age.
Alison Abbott
Multimedia  
 
 
Nature Podcast 15 June 2017
This week, treating infection without antibiotics, wireless charging, and making sense of music.
Correction  
 
 
Correction
 
 
Advertising.
 
 
Comment
 
Fight the silencing of gun research
As anti-science sentiment sweeps the world, it is vital to stop the suppression of firearms studies, argues David Hemenway.
David Hemenway
Books and Arts  
 
 
 
Natural history: Thoreau's debt to Darwin
On the naturalist's bicentenary, Randall Fuller traces his empirical journey after Walden.
Randall Fuller
Neuroscience: How music meets mind
Elizabeth Hellmuth Margulis explores a study parsing how the brain makes sense of melody and harmony.
Elizabeth Hellmuth Margulis
Correspondence  
 
 
 
Publishing: Journals could share peer-review data
Flaminio Squazzoni, Francisco Grimaldo, Ana Marušić
  Tissue engineering: NIH competition to create 'eye in a dish'
Paul A. Sieving
Conservation: Pay countries to stop whaling
Shunsuke Managi, Mihoko Wakamatsu
  Development: Sustainability and resilience differ
Thomas Elmqvist
Junior scientists: Senior scientists as allies for equity
Christina Simkanin, Alison Cawood
 
 
 
Specials
 
SPOTLIGHT  
 
 
 
Patience for patients
Researchers find that perseverance and an altruistic streak keep them going along the long road to drug discovery.
Neil Savage
 
 
Research
 
NEW ONLINE  
 
 
 
Bacterial pathogens: A spoonful of sugar could be the medicine
Pili are filamentous bacterial structures that promote adhesion to host cells. It emerges that a small molecule that inhibits this adhesion can prevent colonization of the mouse gut by a pathogenic bacterium.
Particle physics: No sign of asymmetry in the strong force
The strong force binds the constituents of nuclei together. Differences between the force's fundamental interactions and their mirror images were thought to have been observed in heavy-ion collisions, but new data challenge this picture.
Neuroinflammation: Synapses pruned in lupus
Lupus is an autoimmune disease that can cause brain dysfunction. Studies in mouse models of lupus find that interferon proteins can cause the brain's immune cells to trim the synaptic connections between neurons.
Homeostatic circuits selectively gate food cue responses in insular cortex
A combination of microprism-based cellular imaging to monitor insular cortex visual cue responses in behaving mice across hunger states with circuit mapping and manipulations reveals a neural basis for state-specific biased processing of motivationally relevant cues.
Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2
Prenatal immune suppression is regulated by fetal arginase-2-expressing dendritic cells which respond normally to toll-like receptor stimulation but, in contrast to adult dendritic cells, induce regulatory T cells and repress TNF-α secretion by effector T cells.
Multilineage communication regulates human liver bud development from pluripotency
Single-cell RNA sequencing analysis of two- and three-dimensional hepatic differentiation reveals that both systems recapitulate certain transcriptomic features of human hepatogenesis.
BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation
BRCA1-associated protein 1 (BAP1) regulates calcium flux in the endoplasmic reticulum to facilitate the execution of apoptosis, unveiling a new facet of the role of BAP1 as an environmental tumour suppressor.
Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge
Histone deacetylase 3 (HDAC3) is required to activate brown adipose tissue enhancers to ensure thermogenic aptitude.
ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis
In prostate cancer, the oncogenicity of transcription factor ERG is mediated, in part, by competition with another member of the ETS family, ERF.
Microglia-dependent synapse loss in type I interferon-mediated lupus
Abnormal behavioural phenotypes and synapse loss in the brain of lupus-prone mice are prevented by blocking type I interferon signalling, which is further shown to stimulate microglial phagocytosis of neuronal material in the brains of these mice.
PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth
PTEN, a known tumour suppressor, inhibits the FXBL2-dependent degradation of IP3R3, an IP3 receptor, thus augmenting IP3R3-mediated calcium release from the endoplasmic reticulum to mitochondria and inducing apoptosis; inhibiting FXBL2 sensitizes PTEN-deficient tumours to photodynamic therapy.
Improved maize reference genome with single-molecule technologies OPEN
An improved reference genome for maize, using single-molecule sequencing and high-resolution optical mapping, enables characterization of structural variation and repetitive regions, and identifies lineage expansions of transposable elements that are unique to maize.
Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist
Both F17-like and type 1 pili promote intestinal colonization in mouse colonic crypts, and the high-affinity mannoside M4284 reduces intestinal colonization of uropathogenic Escherichia coli while simultaneously treating urinary tract infections without disrupting the composition of the gut microbiota.
Corrigendum: Common genetic variation drives molecular heterogeneity in human iPSCs
News and Views  
 
 
 
Applied physics: Wireless power on the move
Geoffroy Lerosey
50 & 100 Years Ago
Epidemiology: Molecular mapping of Zika spread
Michael Worobey
 


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Cell cycle: Division enzyme regulates metabolism
Abigail S. Krall, Heather R. Christofk
 
Materials science: How to suck like an octopus
Jonathan J. Wilker
In retrospect: A decade of shared genomic associations
Teri A. Manolio
 
Molecular biology: Local metabolites linked to memory
L. Ashley Watson, Li-Huei Tsai
Perspectives  
 
 
 
Damming the rivers of the Amazon basin
The current and expected environmental consequences of built dams and proposed dam constructions in the Amazon basin are explored with the help of a Dam Environmental Vulnerability Index.
Edgardo M. Latrubesse, Eugenio Y. Arima, Thomas Dunne et al.
Articles  
 
 
 
Common genetic variation drives molecular heterogeneity in human iPSCs
Genetic and phenotypic analysis reveals expression quantitative trait loci in human induced pluripotent stem cell lines associated with cancer and disease.
Helena Kilpinen, Angela Goncalves, Andreas Leha et al.
A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis
The establishment of a drug-discovery screening pipeline for cryptosporidiosis, and identification of pyrazolopyridines as selective ATP-competitive inhibitors of the Cryptosporidium lipid kinase PI(4)K.
Ujjini H. Manjunatha, Sumiti Vinayak, Jennifer A. Zambriski et al.
Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory
The metabolic enzyme acetyl coenzyme A synthetase directly regulates gene expression during memory formation by binding to specific genes and providing acetyl coenzyme A for histone acetylation.
Philipp Mews, Greg Donahue, Adam M. Drake et al.
Letters  
 
 
 
Slush-like polar structures in single-crystal relaxors
Molecular dynamics simulations of the Pb(Mg1/3,Nb2/3)O3–PbTiO3 relaxor reveal a multi-domain state analogous to the slush state of water that provides an explanation for the unusual properties of relaxors.
Hiroyuki Takenaka, Ilya Grinberg, Shi Liu et al.
Genomic epidemiology reveals multiple introductions of Zika virus into the United States
Genome sequencing of Zika virus samples from infected patients and Aedes aegypti mosquitoes in Florida shows that the virus was probably introduced into the United States on multiple occasions, and that the Caribbean is the most likely source.
Nathan D. Grubaugh, Jason T. Ladner, Moritz U. G. Kraemer et al.
Stability and function of regulatory T cells expressing the transcription factor T-bet
Regulatory T cells expressing the transcription factor T-bet selectively suppress TH1 and CD8 T cells, but not TH2 or TH17 activation and associated autoimmunity.
Andrew G. Levine, Alejandra Medoza, Saskia Hemmers et al.
The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival
The cyclin D3–CDK6 kinase complex, which is overactive in some cancers, inhibits two key glycolysis enzymes and thereby enhances the levels of antioxidants in cells, promoting tumour cell survival.
Haizhen Wang, Brandon N. Nicolay, Joel M. Chick et al.
Structural basis of CRISPR–SpyCas9 inhibition by an anti-CRISPR protein
The structure of the anti-CRISPR protein AcrIIA4, in complex with a single-guide RNA and Cas9, reveals that the protein inhibits DNA binding and blocks the Cas9 endonuclease active site.
De Dong, Minghui Guo, Sihan Wang et al.
Robust wireless power transfer using a nonlinear parity–time-symmetric circuit
A nonlinear parity–time-symmetric circuit is used to enable robust wireless power transfer to a moving device over a distance of one metre without the need for tuning.
Sid Assawaworrarit, Xiaofang Yu, Shanhui Fan
A wet-tolerant adhesive patch inspired by protuberances in suction cups of octopi
The suction cups found in octopus tentacles are the inspiration for a synthetic adhesive that functions well in dry and wet conditions and is resistant to chemical contamination.
Sangyul Baik, Da Wan Kim, Youngjin Park et al.
Establishment and cryptic transmission of Zika virus in Brazil and the Americas
Virus genomes reveal the establishment of Zika virus in Brazil and the Americas, and provide an appropriate timeframe for baseline (pre-Zika) microcephaly in different regions.
N. R. Faria, J. Quick, I.M. Claro et al.
Zika virus evolution and spread in the Americas
One hundred and ten Zika virus genomes from ten countries and territories involved in the Zika virus epidemic reveal rapid expansion of the epidemic within Brazil and multiple introductions to other regions.
Hayden C. Metsky, Christian B. Matranga, Shirlee Wohl et al.
Principles of early human development and germ cell program from conserved model systems
The authors trace the emergence of porcine primordial germ cells and develop in vitro models of primordial germ cell development from human and monkey pluripotent stem cells in order to provide insight into early human development.
Toshihiro Kobayashi, Haixin Zhang, Walfred W. C. Tang et al.
Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance
Through drug exposure, a rare, transient transcriptional program characterized by high levels of expression of known resistance drivers can get ‘burned in’, leading to the selection of cells endowed with a transcriptional drug resistance and thus more chemoresistant cancers.
Sydney M. Shaffer, Margaret C. Dunagin, Stefan R. Torborg et al.
CORRIGENDUM  
 
 
 
Corrigendum: MC4R-dependent suppression of appetite by bone-derived lipocalin 2
Ioanna Mosialou, Steven Shikhel, Jian-Min Liu et al.
 
 
 
August 9-11, 2017 | New York, NY
 
Presented by: New York University (NYU) | Nature Genetics | Nature Neuroscience
 
 
 
Careers & Jobs
 
Feature  
 
 
 
Salary negotiation: Get what you seek
Eryn Brown
Column  
 
 
 
Plot your course
Nathan L. Vanderford
Futures  
 
 
Custom-made
How to live happily ever after.
Cassandra Khaw
 
 
 
 
 

naturejobs.com

naturejobs.com Science jobs of the week

 
 
 

Post-doctoral Position in Cancer Genomics and Precision Medicine

 
 

Candiolo Cancer Institute-FPO, IRCCS 

 
 
 
 
 

PhD Studentship Positions in Cell-free synthesis of Membrane Proteins

 
 

Fraunhofer IZI-BB, Potsdam-Golm 

 
 
 
 
 

Scientist for viral and non-viral gene delivery methods in vitro (m / f)

 
 

Abbvie 

 
 
 
 
 

Laboratory Head- Life Science Research (m / f)

 
 

Bayer AG  

 
 
 
 
 

PK / PD Modellers

 
 

GlaxoSmithKline (GSK)  

 
 
 
 
 

The Research Training Group TJ-Train Offers 12 PhD Positions In Tight Junction Research

 
 

Charite, University Medicine Berlin 

 
 
 
 
 

Tenure-Track Assistant Professor in the Department of Pharmacology and Toxicology

 
 

Faculty of Biology and Medicine, Department of Pharmacology and Toxicology 

 
 
 
 
 

Postdoc (m / f) Quantitative Systems Pharmacology Modelling of Rheumatoid Arthritis

 
 

Sanofi 

 
 
 
 
 

New group leaders at the IPBS Institute

 
 

Centre National de la Recherche Scientifique (CNRS) 

 
 
 
 
 

Professorship (W2) (6 years / tenure track) of Molecular Pharmacology

 
 

Ludwig-Maximilians-Universität München, Faculty of Medicine 

 
 
 
 

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  Natureevents Directory featured events  
 
 
 
 

natureevents.com - The premier science events websitenatureevents directory featured events

 
 
 
 

10th International Conference on Science, Technology, Engineering and Management 2017 (ICSTEM 2017)

 
 

27.12.17 Langkawi, Malaysia

 
 
 
 

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