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donderdag 16 maart 2017

The Lancet: [Series] Effectiveness of interventions for diagnosis and treatment of tuberculosis in hard-to-reach popu...

[Series] Effectiveness of interventions for diagnosis and treatment of tuberculosis in hard-to-reach populations in countries of low and medium tuberculosis incidence: a systematic review
Tuberculosis is over-represented in hard-to-reach (underserved) populations in high-income countries of low tuberculosis incidence. The mainstay of tuberculosis care is early detection of active tuberculosis (case finding), contact tracing, and treatment completion. We did a systematic review with a scoping component of relevant studies published between 1990 and 2015 to update and extend previous National Institute for Health and Care Excellence (NICE) reviews on the effectiveness of interventions for identifying and managing tuberculosis in hard-to-reach populations.
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[Series] Barriers and facilitators to the uptake of tuberculosis diagnostic and treatment services by hard-to-reach populations in countries of low and medium tuberculosis incidence: a systematic review of qualitative literature
Tuberculosis disproportionately affects hard-to-reach populations, such as homeless people, migrants, refugees, prisoners, or drug users. These people often face challenges in accessing quality health care. We did a systematic review of the qualitative literature to identify barriers and facilitators to the uptake of tuberculosis diagnostic and treatment services by people from hard-to-reach populations in all European Union (EU), European Economic Area, EU candidate, and Organisation for Economic Co-operation and Development countries.
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[Review] Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy
Congenital cytomegalovirus is the most frequent, yet under-recognised, infectious cause of newborn malformation in developed countries. Despite its clinical and public health importance, questions remain regarding the best diagnostic methods for identifying maternal and neonatal infection, and regarding optimal prevention and therapeutic strategies for infected mothers and neonates. The absence of guidelines impairs global efforts to decrease the effect of congenital cytomegalovirus. Data in the literature suggest that congenital cytomegalovirus infection remains a research priority, but data are yet to be translated into clinical practice.
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[Comment] Tuberculosis is changing
This March, Public Health England will officially launch a routine whole-genome sequencing service for mycobacterial infections, becoming the first national administration in the world to do so. The implications are profound with many of the methods that have become commonplace around the world being replaced. From now on, when mycobacterial cultures are referred to reference facilities, comprehensive whole-genome sequencing-based reports will be returned within 5–7 days. Reports will detail mycobacterial species, and predict drug susceptibility and genetic relatedness for the Mycobacterium tuberculosis complex.
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[Profile] Obituary—Patrick Sissons
Sir Patrick Sissons, former Regius Professor of Physic at the University of Cambridge, pioneered studies of host–pathogen interactions, particularly of cytomegalovirus. He died on Sept 25, 2016.
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