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woensdag 15 maart 2017

The EMBO Journal Table of Contents for 15 March 2017; Vol. 36, No. 6

Beatson Conference www.beatson.gla.ac.co.uk/conf
15 March 2017 | Volume 36, Number 6 Submit


Table of Contents

News & Views
Articles
COVER

Volume 36, Number 6



News & Views
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Trait mapping to a pollen‐specific phospholipase elucidates the molecular basis of a widely used shortcut for haploid induction in maize breeding.

David Jackson
Published online 06.03.2017

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Pax5 fusion proteins exert a gain‐of‐function effect on transcription that contributes to the onset of lymphoblastic leukemia by preventing B‐cell differentiation, thus increasing the risk of oncogenic transformation.

Ameera Alsadeq and Hassan Jumaa
Published online 08.03.2017

Articles
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The function of the patatin‐like phospholipase A NOT LIKE DAD (NLD) in the sperm cells of maize pollen is necessary for successful fertilization, whereas its disruption promotes the development of haploid embryos, which represent an important plant breeding tool.

Laurine M Gilles, Abdelsabour Khaled, Jean‐Baptiste Laffaire, Sandrine Chaignon, Ghislaine Gendrot, Jérôme Laplaige, Hélène Bergès, Genséric Beydon, Vincent Bayle, Pierre Barret, Jordi Comadran, Jean‐Pierre Martinant, Peter M Rogowsky, and Thomas Widiez
Published online 22.02.2017

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New mouse models for PAX5 fusion proteins found in acute lymphoblastic leukemia reveal that oncogenesis involves loss of cell cycle inhibitors rather than deregulation of known PAX5 target genes.

Leonie Smeenk, Maria Fischer, Sabine Jurado, Markus Jaritz, Anna Azaryan, Barbara Werner, Mareike Roth, Johannes Zuber, Martin Stanulla, Monique L den Boer, Charles G Mullighan, Sabine Strehl, and Meinrad Busslinger
Published online 20.02.2017

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Aberrant mTORC1 signalling induces cell senescence via S6 kinase‐mediated phosphorylation of epigenetic factor ZRF1, thereby linking nutritional cues to regulation of cell fitness.

Manuela Barilari, Gregory Bonfils, Caroline Treins, Vonda Koka, Delphine De Villeneuve, Sylvie Fabrega, and Mario Pende
Published online 27.02.2017 Open Access

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Escherichia coli K1 uses its polysialic acid capsule to interact with Siglec‐11 to escape host immune responses, but this is counteracted by the activating Siglec‐16.

Flavio Schwarz, Corinna S Landig, Shoib Siddiqui, Ismael Secundino, Joshua Olson, Nissi Varki, Victor Nizet, and Ajit Varki
Published online 18.01.2017

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GADD34 coordinates transcriptional and translational responses to viral dsRNA to optimize type‐I IFN production.

Alexandre Dalet, Rafael J Argüello, Alexis Combes, Lionel Spinelli, Sebastien Jaeger, Mathieu Fallet, Thien‐Phong Vu Manh, Andreia Mendes, Jessica Perego, Marisa Reverendo, Voahirana Camosseto, Marc Dalod, Tobias Weil, Manuel A Santos, Evelina Gatti, and Philippe Pierre
Published online 18.01.2017

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Small heat shock proteins initially facilitate solubilization of misfolded protein aggregates, but need to be selectively dissociated to facilitate subsequent access of ATP‐dependent refolding chaperones.

Szymon Żwirowski, Agnieszka Kłosowska, Igor Obuchowski, Nadinath B Nillegoda, Artur Piróg, Szymon Ziętkiewicz, Bernd Bukau, Axel Mogk, and Krzysztof Liberek
Published online 20.02.2017

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The activation of mitochondrial Na+/Ca2+ exchanger NCLX controls Orai1 redox state to ensure maintenance of store‐operated calcium entry (SOCE), thus shedding light on how mitochondria are linked to regulation of SOCE.

Tsipi Ben‐Kasus Nissim, Xuexin Zhang, Assaf Elazar, Soumitra Roy, Judith A Stolwijk, Yandong Zhou, Rajender K Motiani, Maxime Gueguinou, Nadine Hempel, Michal Hershfinkel, Donald L Gill, Mohamed Trebak, and Israel Sekler
Published online 20.02.2017

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Munc13‐1 catalyzes the transition from the Munc18‐1/syntaxin‐1 complex to the SNARE complex critical for synaptic vesicle priming. This study shows that Munc13‐1 induces a local conformational change in the syntaxin‐1 linker region that promotes this transition.

Shen Wang, Ucheor B Choi, Jihong Gong, Xiaoyu Yang, Yun Li, Austin L Wang, Xiaofei Yang, Axel T Brunger, and Cong Ma
Published online 30.01.2017

 

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