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woensdag 1 maart 2017

The EMBO Journal Table of Contents for 01 March 2017; Vol. 36, No. 5

01 March 2017 | Volume 36, Number 5 Submit


Table of Contents

News & Views
Review
Articles
COVER

Volume 36, Number 5



News & Views
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Microglia function and their phagocytic capacity can be restored in an ex vivo Alzheimer's disease model system enabling the clearance of amyloid plaques.

Knut Biber
Published online 17.02.2017

Review
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This review discusses concepts for establishment of cellular heterogeneity in tissues, and proposes that cell identity is dynamically maintained in a cognitive manner, rather than intrinsically predetermined.

Aneta Koseska and Philippe IH Bastiaens
Published online 30.01.2017

Articles
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Impaired phagocytic function of aged microglia can be rescued via GM‐CSF secretion from co‐cultured young microglia in amyloid‐bearing organotypic tissue.

Anna Daria, Alessio Colombo, Gemma Llovera, Heike Hampel, Michael Willem, Arthur Liesz, Christian Haass, and Sabina Tahirovic
Published online 21.12.2016

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Terminally differentiated macrophages displaying a Raf/MEK/ERK pathway‐dependent G1‐like cell cycle expression profile are permissive to HIV‐1 infection due to deactivation of the host HIV‐1 restriction factor SAMHD1.

Petra Mlcochova, Katherine A Sutherland, Sarah A Watters, Cosetta Bertoli, Rob AM de Bruin, Jan Rehwinkel, Stuart J Neil, Gina M Lenzi, Baek Kim, Asim Khwaja, Matthew C Gage, Christiana Georgiou, Alexandra Chittka, Simon Yona, Mahdad Noursadeghi, Greg J Towers, and Ravindra K Gupta
Published online 25.01.2017 Open Access

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Why certain loci are able to stably switch between alternative epigenetic states (forming heritable epialleles), while others remain resistant to such switches seems to be predetermined by their genetic features, such as DNA sequence composition and repetitiveness.

Marco Catoni, Jayne Griffiths, Claude Becker, Nicolae Radu Zabet, Carlos Bayon, Mélanie Dapp, Michal Lieberman‐Lazarovich, Detlef Weigel, and Jerzy Paszkowski
Published online 09.01.2017 Open Access

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Thermodynamic and intrinsic affinity measurements show how intramolecular interactions of integrin receptor domains and post‐translational modifications regulate activation of ligand binding.

Jing Li, Yang Su, Wei Xia, Yan Qin, Martin J Humphries, Dietmar Vestweber, Carlos Cabañas, Chafen Lu, and Timothy A Springer
Published online 25.01.2017 Open Access

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Proteomics‐based identification of distinct molecular interactions and modifications of wild‐type and melanoma‐associated mutant BRAF reveals the effects of BRAF activators and inhibitors on the quaternary structure of this major therapeutic target.

Britta Diedrich, Kristoffer TG Rigbolt, Michael Röring, Ricarda Herr, Stephanie Kaeser‐Pebernard, Christine Gretzmeier, Robert F Murphy, Tilman Brummer, and Jörn Dengjel
Published online 16.01.2017

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Cdc7‐Dbf4 kinase joins CDK and Cdc5/Plk cell cycle kinases to exquisitely time resolution of DNA joint molecules before cell division.

Lissa N Princz, Philipp Wild, Julia Bittmann, F Javier Aguado, Miguel G Blanco, Joao Matos, and Boris Pfander
Published online 17.01.2017 Open Access

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Distinct conformations of Chandipura virus glycoprotein reveal the chronological order of fusion‐associated structural changes, including an early‐stage requirement for antiparallel fusion domain interactions.

Eduard Baquero, Aurélie A Albertini, Hélène Raux, Abbas Abou‐Hamdan, Elisabetta Boeri‐Erba, Malika Ouldali, Linda Buonocore, John K Rose, Jean Lepault, Stéphane Bressanelli, and Yves Gaudin
Published online 10.02.2017

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Folding of proteins entering the secretory pathway in mammalian cells necessitates disulfide bond formation in the ER. This study shows that cytosolic thioredoxin reductase 1 and NADPH are required to reduce non‐native disulfides in such proteins.

Greg J Poet, Ojore BV Oka, Marcel van Lith, Zhenbo Cao, Philip J Robinson, Marie Anne Pringle, Elias SJ Arnér, and Neil J Bulleid
Published online 16.01.2017 Open Access

 

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