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dinsdag 14 maart 2017

Scientific Reports Health Sciences Table of Contents e-alert: 14 March 2017

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  14 March 2017   
 
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Welcome to your Table of Contents e-alert for Scientific Reports

 
 
 
 
 
 
Read the latest key research on aging and age-related diseases from npj Aging and Mechanisms of Disease - an open access journal published in partnership with the Japanese Society of Anti-Aging Medicine (JAAM)

Auditory system senescence: Mitochondrial dynamics and respiration 
Regenerative medicine: lacrimal gland epithelium in vitro
 
 
 
 
 
 
 
Health Sciences
 
 
 
 
 
 
 

Immunofluorescence identifies distinct subsets of endothelial cells in the human liver

 
 

Otto Strauss, Anthony Phillips, Katya Ruggiero et al.

 
 

As well as systemic vascular endothelial cells, the liver has specialised sinusoidal endothelial cells (LSEC). LSEC dysfunction has been documented in many diseased states yet …

 
 
 
 
 
 

Radiation-associated circulatory disease mortality in a pooled analysis of 77,275 patients from the Massachusetts and Canadian tuberculosis fluoroscopy cohorts

 
 

Van Tran, Lydia B. Zablotska, Alina V. Brenner et al.

 
 

High-dose ionising radiation is associated with circulatory disease. Risks associated with lower-dose (<0.5 Gy) exposures remain unclear, with little information on risk …

 
 
 
 
 
 

Serum Macro TSH Level is Associated with Sleep Quality in Patients with Cardiovascular Risks – HSCAA Study

 
 

Manabu Kadoya, Sachie Koyama, Akiko Morimoto et al.

 
 

Macro thyroid-stimulating hormone (TSH) has been reported to be associated with seasonality and regulated by changes in day length in rodents, different from free TSH. In the …

 
 
 
 
 
 

Patterns of Default Mode Network Deactivation in Obsessive Compulsive Disorder

 
 

Óscar F. Gonçalves, José Miguel Soares, Sandra Carvalho et al.

 
 

The objective of the present study was to research the patterns of Default Mode Network (DMN) deactivation in Obsessive Compulsive Disorder (OCD) in the transition between a …

 
 
 
 
 
 

ELF5-Mediated AR Activation Regulates Prostate Cancer Progression

 
 

Kai Li, Yongmin Guo, Xiong Yang et al.

 
 

The transcription factor E74-like factor 5 (ELF5) is a potent antioncogene that can prevent epithelial-mesenchymal transition (EMT) and metastasis in prostate cancer (PCa). …

 
 
 
 
 
 

Neurovascular microcirculatory vasodilation mediated by C-fibers and Transient receptor potential vanilloid-type-1 channels (TRPV 1) is impaired in type 1 diabetes

 
 

P. Marche, S. Dubois, P. Abraham et al.

 
 

Microvascular dysfunction may have an early onset in type 1 diabetes (T1D) and can precede major complications. Our objectives were to assess the endothelial-dependent …

 
 
 
 
 
 

Prognostic and clinicopathological role of high Ki-67 expression in patients with renal cell carcinoma: a systematic review and meta-analysis

 
 

Yongpeng Xie, Luyao Chen, Xin Ma et al.

 
 

Previous studies have elevated the prognostic value of Ki-67 in renal cell carcinoma (RCC), but the reports are controversial and inconsistent. We conducted a systematic review …

 
 
 
 
 
 

Similarities and differences of functional connectivity in drug-naïve, first-episode adolescent and young adult with major depressive disorder and schizophrenia

 
 

Shengnan Wei, Fay Womer, Haiyang Geng et al.

 
 

Major depressive disorder (MDD) and schizophrenia (SZ) are considered two distinct psychiatric disorders. Yet, they have considerable overlap in symptomatology and clinical …

 
 
 
 
 
 

CRISPR/Cas9-generated p47phox-deficient cell line for Chronic Granulomatous Disease gene therapy vector development

 
 

Dominik Wrona, Ulrich Siler, Janine Reichenbach

 
 

Development of gene therapy vectors requires cellular models reflecting the genetic background of a disease thus allowing for robust preclinical vector testing. For human p47phox

 
 
 
 
 
 

Blockade of vascular endothelial growth factor receptors by tivozanib has potential anti-tumour effects on human glioblastoma cells

 
 

Majid Momeny, Farima Moghaddaskho, Narges K. Gortany et al.

 
 

Glioblastoma (GBM) remains one of the most fatal human malignancies due to its high angiogenic and infiltrative capacities. Even with optimal therapy including surgery, …

 
 
 
 
 
 

Hydrogel increases localized transport regions and skin permeability during low frequency ultrasound treatment

 
 

Tatiana Aparecida Pereira, Danielle Nishida Ramos, Renata F. V. Lopez

 
 

Low frequency ultrasound (LFU) enhances skin permeability via the formation of heterogeneous localized transport regions (LTRs). In this work, hydrogels with different zeta …

 
 
 
 
 
 

Restoring the impaired cardiac calcium homeostasis and cardiac function in iron overload rats by the combined deferiprone and N-acetyl cysteine

 
 

Suwakon Wongjaikam, Sirinart Kumfu, Juthamas Khamseekaew et al.

 
 

Intracellular calcium [Ca2+]i dysregulation plays an important role in the pathophysiology of iron overload cardiomyopathy. Although either iron chelators or antioxidants provide …

 
 
 
 
 
 

Fluorogenic Peptide Substrate for Quantification of Bacterial Enzyme Activities

 
 

Ismail H. Al-Abdullah, Karine Bagramyan, Shiela Bilbao et al.

 
 

A novel peptide substrate (A G G P L G P P G P G G) was developed for quantifying the activities of bacterial enzymes using a highly sensitive Fluorescence Resonance Energy …

 
 
 
 
 
 

Heterogeneity assessment of functional T cell avidity

 
 

Kalliopi Ioannidou, Petra Baumgaertner, Philippe O. Gannon et al.

 
 

The potency of cellular immune responses strongly depends on T cell avidity to antigen. Yet, functional avidity measurements are rarely performed in patients, mainly due to the …

 
 
 
 
 
 

AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins

 
 

Marina Riggio, María C. Perrone, María L. Polo et al.

 
 

The purpose of this study was to elucidate the mechanisms associated with the specific effects of AKT1 and AKT2 isoforms in breast cancer progression. We modulated the abundance …

 
 
 
 
 
 

Synergistic Degradation of a Hyperuricemia-Causing Metabolite Using One-Pot Enzyme-Nanozyme Cascade Reactions

 
 

Secheon Jung, Inchan Kwon

 
 

Multi-enzyme cascade reactions are frequently found in living organisms, in particular when an intermediate should be eliminated. Recently, enzyme-mimic nanomaterials (nanozymes) …

 
 
 
 
 
 

Multivariate simulation framework reveals performance of multi-trait GWAS methods

 
 

Heather F. Porter, Paul F. O’Reilly

 
 

Burgeoning availability of genome-wide association study (GWAS) results and national biobank data has led to growing interest in performing multi-trait genetic analyses. Numerous …

 
 
 
 
 
 

Chitosan nerve conduits seeded with autologous bone marrow mononuclear cells for 30 mm goat peroneal nerve defect

 
 

Aikeremujiang Muheremu, Lin Chen, Xiyuan Wang et al.

 
 

In the current research, to find if the combination of chitosan nerve conduits seeded with autologous bone marrow mononuclear cells (BM-MNCs) can be used to bridge 30 mm long …

 
 
 
 
 
 

A codon-shuffling method to prevent reversion during production of replication-defective herpesvirus stocks: Implications for herpesvirus vaccines

 
 

Gang Li, Charles Ward, Rukhsana Yeasmin et al.

 
 

Herpesviruses establish life-long chronic infections that place infected hosts at risk for severe disease. Herpesvirus genomes readily undergo homologous recombination (HR) …

 
 
 
 
 
 

Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue

 
 

Jarrett D. Morrow, Xiaobo Zhou, Taotao Lao et al.

 
 

In comparison to genome-wide association studies (GWAS), there has been poor replication of gene expression studies in chronic obstructive pulmonary disease (COPD). We performed …

 
 
 
 
 
 

A ‘Disease Severity Index’ to identify individuals with Subjective Memory Decline who will progress to mild cognitive impairment or dementia

 
 

Daniel Ferreira, Farshad Falahati, Cecilia Linden et al.

 
 

Subjective memory decline (SMD) is a heterogeneous condition. While SMD might be the earliest sign of Alzheimer’s disease (AD), it also occurs in aging and various neurological, …

 
 
 
 
 
 

Assessing the risk of an emerging zoonosis of worldwide concern: anisakiasis

 
 

Miguel Bao, Graham J. Pierce, Santiago Pascual et al.

 
 

Anisakiasis is an emerging zoonosis caused by the fish parasitic nematode Anisakis. Spain appears to have the highest reported incidence in Europe and marinated anchovies are …

 
 
 
 
 
 

Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson’s disease

 
 

Brianada Koentjoro, Jin-Sung Park, Carolyn M. Sue

 
 

Therapeutic targets are needed to develop neuroprotective treatments for Parkinson’s disease (PD). Mitophagy, the selective autophagic elimination of dysfunctional mitochondria, …

 
 
 
 
 
 

Electro-echocardiographic Indices to Predict Cardiac Resynchronization Therapy Non-response on Non-ischemic Cardiomyopathy

 
 

Ziqing Yu, Xueying Chen, Fei Han et al.

 
 

Cardiac resynchronization therapy (CRT) threw lights on heart failure treatment, however, parts of patients showed nonresponse to CRT. Unfortunately, it lacks effective …

 
 
 
 
 
 

Incidence and outcomes of uterine rupture among women with prior caesarean section: WHO Multicountry Survey on Maternal and Newborn Health

 
 

Kenichiro Motomura, Togoobaatar Ganchimeg, Chie Nagata et al.

 
 

Caesarean section (CS) is increasing globally, and women with prior CS are at higher risk of uterine rupture in subsequent pregnancies. However, little is known about the …

 
 
 
 
 
 

Carnosine Attenuates the Development of both Type 2 Diabetes and Diabetic Nephropathy in BTBR ob/ob Mice

 
 

Thomas Albrecht, Maaike Schilperoort, Shiqi Zhang et al.

 
 

We previously demonstrated that polymorphisms in the carnosinase-1 gene (CNDP1) determine the risk of nephropathy in type 2 diabetic patients. Carnosine, the substrate of the …

 
 
 
 
 
 

Excretion rates of 1,5-anhydro-D-glucitol, uric acid and microalbuminuria as glycemic control indexes in patients with type 2 diabetes

 
 

Cong Ma, Junqin Sheng, Zhiwen Liu et al.

 
 

1,5-anhydroglucitol (1,5-AG), uric acid and urinary proteins are excreted into the urine with increasing glucosuria. In the present retrospective study we analyzed whether these …

 
 
 
 
 
 

Oral bisphosphonates and colorectal cancer

 
 

Emily Vogtmann, Douglas A. Corley, Lucy M. Almers et al.

 
 

Use of oral bisphosphonates has been associated with a decreased risk of colorectal cancer (CRC), but the association may be related to residual confounding by healthy lifestyle …

 
 
 
 
 
 

Assessing muscle spasticity with Myotonometric and passive stretch measurements: validity of the Myotonometer

 
 

Xiaoyan Li, Henry Shin, Sheng Li et al.

 
 

Spasticity of the biceps brachii muscle was assessed using the modified Ashworth Scale (MAS), Myotonometry and repeated passive stretch techniques, respectively. Fourteen …

 
 
 
 
 
 

A De Novo Nonsense Mutation in MAGEL2 in a Patient Initially Diagnosed as Opitz-C: Similarities Between Schaaf-Yang and Opitz-C Syndromes

 
 

Roser Urreizti, Anna Maria Cueto-Gonzalez, Héctor Franco-Valls et al.

 
 

Opitz trigonocephaly C syndrome (OTCS) is a rare genetic disorder characterized by craniofacial anomalies, variable intellectual and psychomotor disability, and variable cardiac …

 
 
 
 
 
 

Chemogenetic stimulation of the hypoglossal neurons improves upper airway patency

 
 

Thomaz Fleury Curado, Kenneth Fishbein, Huy Pho et al.

 
 

Obstructive sleep apnea (OSA) is characterized by recurrent upper airway obstruction during sleep. OSA leads to high cardiovascular morbidity and mortality. The pathogenesis of …

 
 
 
 
 
 

Screening for diabetes mellitus among tuberculosis patients in Southern Nigeria: a multi-centre implementation study under programme settings

 
 

Ngozi Ekeke, Kingsley N. Ukwaja, Joseph N. Chukwu et al.

 
 

Implementation studies are recommended to assess the feasibility and effectiveness of programmes. In Nigeria, little is known about the burden of diabetes mellitus (DM) among …

 
 
 
 
 
 

Influence of dairy by-product waste milk on the microbiomes of different gastrointestinal tract components in pre-weaned dairy calves

 
 

Y. F. Deng, Y. J. Wang, Y. Zou et al.

 
 

The community structure of colonised bacteria in the gastrointestinal tracts (GITs) of pre-weaned calves is affected by extrinsic factors, such as the genetics and diet of the …

 
 
 
 
 
 

DPP-4 Inhibitor and Estrogen Share Similar Efficacy Against Cardiac Ischemic-Reperfusion Injury in Obese-Insulin Resistant and Estrogen-Deprived Female Rats

 
 

Sivaporn Sivasinprasasn, Pongpan Tanajak, Wanpitak Pongkan et al.

 
 

Estrogen deprivation aggravates cardiac injury after myocardial ischemia and reperfusion (I/R) injury. Although either estrogen or the dipeptidyl peptidase-4 (DPP-4) inhibitor, …

 
 
 
 
 
 

Standardized and flexible eight colour flow cytometry panels harmonized between different laboratories to study human NK cell phenotype and function

 
 

John P. Veluchamy, María Delso-Vallejo, Nina Kok et al.

 
 

Advancements in multi-colour fluorescence activated cell sorting (FACS) panel warrant harmonized procedures to obtain comparable data between various laboratories. The …

 
 
 
 
 
 

Association of SCN10A Polymorphisms with the Recurrence of Atrial Fibrillation after Catheter Ablation in a Chinese Han Population

 
 

Haiqing Wu, Juan Xu, Songwen Chen et al.

 
 

The nonsynonymous SCN10A single nucleotide polymorphism (SNP) rs6795970 has been reported to associate with PR interval and atrial fibrillation (AF) and in strong linkage …

 
 
 
 
 
 

Noninvasive scoring system for significant inflammation related to chronic hepatitis B

 
 

Mei-Zhu Hong, Linglong Ye, Li-Xin Jin et al.

 
 

Although a liver stiffness measurement-based model can precisely predict significant intrahepatic inflammation, transient elastography is not commonly available in a primary care …

 
 
 
 
 
 

Reactive oxygen species are required for zoledronic acid-induced apoptosis in osteoclast precursors and mature osteoclast-like cells

 
 

Ta-Wei Tai, Ching-Yu Chen, Fong-Chin Su et al.

 
 

Inhibiting osteoclasts and osteoclast precursors to reduce bone resorption is an important strategy to treat osteoclast-related diseases, such as osteoporosis, inflammatory bone …

 
 
 
 
 
 

Genome-wide copy number variation analysis in a Chinese autism spectrum disorder cohort

 
 

Hui Guo, Yu Peng, Zhengmao Hu et al.

 
 

Autism spectrum disorder (ASD) describes a group of neurodevelopmental disorders with high heritability, although the underlying genetic determinants of ASDs remain largely …

 
 
 
 
 
 

Valuation in major depression is intact and stable in a non-learning environment

 
 

Dongil Chung, Kelly Kadlec, Jason A. Aimone et al.

 
 

The clinical diagnosis and symptoms of major depressive disorder (MDD) have been closely associated with impairments in reward processing. In particular, various studies have …

 
 
 
 
 
 

New insights into the intracellular distribution pattern of cationic amphiphilic drugs

 
 

Magdalena Vater, Leonhard Möckl, Vanessa Gormanns et al.

 
 

Cationic amphiphilic drugs (CADs) comprise a wide variety of different substance classes such as antidepressants, antipsychotics, and antiarrhythmics. It is well recognized that …

 
 
 
 
 
 

Advanced analytical methodologies for measuring healthy ageing and its determinants, using factor analysis and machine learning techniques: the ATHLOS project

 
 

Francisco Félix Caballero, George Soulis, Worrawat Engchuan et al.

 
 

A most challenging task for scientists that are involved in the study of ageing is the development of a measure to quantify health status across populations and over time. In the …

 
 
 
 
 
 

IL-17 induces reactive astrocytes and up-regulation of vascular endothelial growth factor (VEGF) through JAK/STAT signaling

 
 

Tao You, Yihui Bi, Jun li et al.

 
 

Spinal cord injury is a grave neurological disability resulting in neuron degeneration and permanent paralysis. The inflammation triggered by the injury would promote the spinal …

 
 
 
 
 
 

The need for strengthening the influenza virus detection ability of hospital clinical laboratories: an investigation of the 2009 pandemic

 
 

Shigui Yang, Yuqing Zhou, Yuanxia Cui et al.

 
 

Most hospital clinical laboratories (HCLs) in China are unable to perform influenza virus detection. It remains unclear whether the influenza detection ability of HCLs influences …

 
 
 
 
 
 

Effects of silk fibroin in murine dry eye

 
 

Chae Eun Kim, Ji Hyun Lee, Yeung Kyu Yeon et al.

 
 

The study aimed to investigate the effects of silk fibroin in a mouse model of dry eye. The experimental dry eye mouse model was developed using more than twelve-weeks-old …

 
 
 
 
 
 

Rat umbilical cord blood cells attenuate hypoxic–ischemic brain injury in neonatal rats

 
 

Keiko Nakanishi, Yoshiaki Sato, Yuka Mizutani et al.

 
 

Increasing evidence has suggested that human umbilical cord blood cells (hUCBC) have a favorable effect on hypoxic–ischemic (HI) brain injury. However, the efficacy of using hUC…

 
 
 
 
 
 

Ibuprofen results in alterations of human fetal testis development

 
 

Millissia Ben Maamar, Laurianne Lesné, Kristin Hennig et al.

 
 

Among pregnant women ibuprofen is one of the most frequently used pharmaceutical compounds with up to 28% reporting use. Regardless of this, it remains unknown whether ibuprofen …

 
 
 
 
 
 

Non-invasive Assessment of Cerebral Blood Flow and Oxygen Metabolism in Neonates during Hypothermic Cardiopulmonary Bypass: Feasibility and Clinical Implications

 
 

Silvina L. Ferradal, Koichi Yuki, Rutvi Vyas et al.

 
 

The neonatal brain is extremely vulnerable to injury during periods of hypoxia and/or ischemia. Risk of brain injury is increased during neonatal cardiac surgery, where …

 
 
 
 
 
 

Flunarizine suppresses endothelial Angiopoietin-2 in a calcium - dependent fashion in sepsis

 
 

Jennifer Retzlaff, Kristina Thamm, Chandra C. Ghosh et al.

 
 

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to an infection leading to systemic inflammation and endothelial barrier breakdown. The …

 
 
 
 
 
 

The Contrast Enhancement of Intracranial Arterial Wall on High-resolution MRI and Its Clinical Relevance in Patients with Moyamoya Vasculopathy

 
 

Maoxue Wang, Yongbo Yang, Fei Zhou et al.

 
 

The purpose of this study is to investigate the characteristics of intracranial vessel wall enhancement and its relationship with ischemic infarction in patients with Moyamoya …

 
 
 
 
 
 

MRI Assessment of Cardiomyopathy Induced by β1-Adrenoreceptor Autoantibodies and Protection Through β3-Adrenoreceptor Overexpression

 
 

Laetitia Vanhoutte, Céline Guilbaud, Ruben Martherus et al.

 
 

The cardiopathogenic role of autoantibodies (aabs) directed against β1-adrenoreceptors (β1-AR) is well established. In mouse models, they cause progressive dilated cardiomyopathy …

 
 
 
 
 
 

Conditional Survival Analysis of Patients With Locally Advanced Laryngeal Cancer: Construction of a Dynamic Risk Model and Clinical Nomogram

 
 

$author.fullName, Tommy Sheu, David M. Vock et al.

 
 

Conditional survival (CS), the survival beyond a pre-defined time interval, can identify periods of higher mortality risk for patients with locally advanced laryngeal cancer who …

 
 
 
 
 
 

Diet-induced obesity impairs spermatogenesis: a potential role for autophagy

 
 

Yang Mu, Wen-jie Yan, Tai-lang Yin et al.

 
 

Autophagy is an evolutionarily conserved process that plays a crucial role in maintaining a series of cellular functions. It has been found that autophagy is closely involved in …

 
 
 
 
 
 

Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma

 
 

Sonia Coni, Anna Barbara Mancuso, Laura Di Magno et al.

 
 

SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with …

 
 
 
 
 
 

The acute airway inflammation induced by PM2.5 exposure and the treatment of essential oils in Balb/c mice

 
 

Hetong Wang, Laiyu Song, Wenhui Ju et al.

 
 

PM2.5 is the main particulate air pollutant whose aerodynamic diameter is less than 2.5 micron. The inflammation of various respiratory diseases are associated with PM2.5

 
 
 
 
 
 

Pathologic Roles of Receptor-Associated Prorenin System in Idiopathic Epiretinal Membrane

 
 

Yoko Dong, Atsuhiro Kanda, Kousuke Noda et al.

 
 

Receptor-associated prorenin system (RAPS) refers to the pathogenic mechanism whereby prorenin binding to (pro)renin receptor [(P)RR] dually activates tissue renin-angiotensin …

 
 
 
 
 
 

Comparison of human adipose stromal vascular fraction and adipose-derived mesenchymal stem cells for the attenuation of acute renal ischemia/reperfusion injury

 
 

Liuhua Zhou, Qun Song, Jiangwei Shen et al.

 
 

Stem cells therapy has been suggested as a promising option for the treatment of acute kidney injury (AKI). This study was performed to compare the abilities of xenogenic …

 
 
 
 
 
 

TASK channels contribute to neuroprotective action of inhalational anesthetics

 
 

Chengye Yao, Yu Li, Shaofang Shu et al.

 
 

Postconditioning with inhalational anesthetics can reduce ischemia-reperfusion brain injury, although the cellular mechanisms for this effect have not been determined. The …

 
 
 
 
 
 

The efficacy and safety of SGLT2 inhibitors for adjunctive treatment of type 1 diabetes: a systematic review and meta-analysis

 
 

Jiao Chen, Fang Fan, J. Y. Wang et al.

 
 

To assess the efficacy and safety of the SGLT-2 inhibitors as adjunct therapy to insulin in T1DM, clinical trials indexed in PubMed, Cochrane Library, EMbase from inception …

 
 
 
 
 
 

Beta-trace Protein as a new non-invasive immunological Marker for Quinolinic Acid-induced impaired Blood-Brain Barrier Integrity

 
 

Andreas Baranyi, Omid Amouzadeh-Ghadikolai, Dirk von Lewinski et al.

 
 

Quinolinic acid, a macrophage/microglia-derived excitotoxin fulfills a plethora of functions such as neurotoxin, gliotoxin, and proinflammatory mediator, and it alters the …

 
 
 
 
 
 

Erratum: An optimised direct lysis method for gene expression studies on low cell numbers

 
 

Anh Viet-Phuong Le, Dexing Huang, Tony Blick et al.

 
 

 
 
 
 
 
 

Building a 5-HT3A Receptor Expression Map in the Mouse Brain

 
 

Yoshihisa Koyama, Makoto Kondo, Shoichi Shimada

 
 

Of the many serotonin receptors, the type 3 receptors (5-HT3R) are the only ionotropic ones, playing a key role in fast synaptic transmission and cognitive and emotional brain …

 
 
 
 
 
 

Blood DNA methylation pattern is altered in mesial temporal lobe epilepsy

 
 

Hong-Yu Long, Li Feng, Jin Kang et al.

 
 

Mesial temporal lobe epilepsy (MTLE) is a common epileptic disorder; little is known whether it is associated with peripheral epigenetic changes. Here we compared blood whole …

 
 
 
 
 
 

Engineering a vascularised 3D in vitro model of cancer progression

 
 

Tarig Magdeldin, Víctor López-Dávila, Judith Pape et al.

 
 

The hallmark of tumours is the ability of cancerous cells to promote vascular growth, to disseminate and invade to distant organs. The metastatic process is heavily influenced by …

 
 
 
 
 
 

The Interaction Effects of Meteorological Factors and Air Pollution on the Development of Acute Coronary Syndrome

 
 

Ching-Hui Huang, Heng-Cheng Lin, Chen-Dao Tsai et al.

 
 

This study investigated the interaction effects of meteorological factors and air pollutants on the onset of acute coronary syndrome (ACS). Data of ACS patients were obtained …

 
 
 
 
 
 

Variability in statin-induced changes in gene expression profiles of pancreatic cancer

 
 

Helena Gbelcová, Silvie Rimpelová, Tomáš Ruml et al.

 
 

Statins, besides being powerful cholesterol-lowering drugs, also exert potent anti-proliferative activities. However, their anti-cancer efficacy differs among the individual …

 
 
 
 
 
 

The Final (Oral Ebola) Vaccine Trial on Captive Chimpanzees?

 
 

Peter D. Walsh, Drishya Kurup, Dana L. Hasselschwert et al.

 
 

Could new oral vaccine technologies protect endangered wildlife against a rising tide of infectious disease? We used captive chimpanzees to test oral delivery of a rabies virus …

 
 
 
 
 
 

IGF-1 potentiates sensory innervation signalling by modulating the mitochondrial fission/fusion balance

 
 

Yuan Ding, Jianmin Li, Zhen Liu et al.

 
 

Restoring the contractile function of long-term denervated skeletal muscle (SKM) cells is difficult due to the long period of denervation, which causes a loss of contractility. …

 
 
 
 
 
 

Simple Risk Score for Prediction of Early Recurrence of Hepatocellular Carcinoma within the Milan Criteria after Orthotopic Liver Transplantation

 
 

Jiliang Feng, Jushan Wu, Ruidong Zhu et al.

 
 

Ten to twenty percent of the hepatocellular carcinoma (HCC) patients fulfilling the Milan criteria (MC) recurred within three years after orthotopic liver transplantation (OLT). …

 
 
 
 
 
 

Identification of berberine as a direct thrombin inhibitor from traditional Chinese medicine through structural, functional and binding studies

 
 

Xing Wang, Yuxin Zhang, Ying Yang et al.

 
 

Thrombin acts as a key enzyme in the blood coagulation cascade and represents a potential drug target for the treatment of several cardiovascular diseases. The aim of this study …

 
 
 
 
 
 

Analysis of the common genetic component of large-vessel vasculitides through a meta-Immunochip strategy

 
 

F. David Carmona, Patrick Coit, Güher Saruhan-Direskeneli et al.

 
 

Giant cell arteritis (GCA) and Takayasu’s arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, …

 
 
 
 
 
 

Occurrence and functional significance of the transcriptome in bovine (Bos taurus) spermatozoa

 
 

Sellappan Selvaraju, Sivashanmugam Parthipan, Lakshminarayana Somashekar et al.

 
 

Mammalian spermatozoa deliver various classes of RNAs to the oocyte during fertilization, and many of them may regulate fertility. The objective of the present study was to …

 
 
 
 
 
 

Principal Components Analysis Based Unsupervised Feature Extraction Applied to Gene Expression Analysis of Blood from Dengue Haemorrhagic Fever Patients

 
 

Y-h. Taguchi

 
 

Dengue haemorrhagic fever (DHF) sometimes occurs after recovery from the disease caused by Dengue virus (DENV), and is often fatal. However, the mechanism of DHF has not been …

 
 
 
 
 
 

Experimental assessment of the safety and potential efficacy of high irradiance photostimulation of brain tissues

 
 

Senova Suhan, Scisniak Ilona, Chiang Chih-Chieh et al.

 
 

Optogenetics is widely used in fundamental neuroscience. Its potential clinical translation for brain neuromodulation requires a careful assessment of the safety and efficacy of …

 
 
 
 
 
 

Robust Identification of Alzheimer’s Disease subtypes based on cortical atrophy patterns

 
 

Jong-Yun Park, Han Kyu Na, Sungsoo Kim et al.

 
 

Accumulating evidence suggests that Alzheimer’s disease (AD) is heterogenous and can be classified into several subtypes. Here, we propose a robust subtyping method for AD based …

 
 
 
 
 
 

Restricted Use of Erythropoiesis-Stimulating Agent is Safe and Associated with Deferred Dialysis Initiation in Stage 5 Chronic Kidney Disease

 
 

Szu-Yu Pan, Wen-Chih Chiang, Ping-Min Chen et al.

 
 

The effect of erythropoiesis-stimulating agent (ESA) on dialysis initiation in advanced chronic kidney disease (CKD) patients is not clear. We retrospectively analyzed the …

 
 
 
 
 
 

A possible role for neutrophils in allergic rhinitis revealed after cellular subclassification

 
 

Julia Arebro, Sandra Ekstedt, Eric Hjalmarsson et al.

 
 

A re-examination of former concepts is required to meet today’s medical challenges in allergic rhinitis. Previously, neutrophils have been treated as a relatively homogenous cell …

 
 
 
 
 
 

Accuracy and safety verification of ovarian reserve assessment technique for ovarian tissue transplantation using optical coherence tomography in mice ovary

 
 

Seido Takae, Kosuke Tsukada, Yorino Sato et al.

 
 

Except for histological study, there are currently no suitable techniques available for the detection and identification of primordial follicles in ovary of primary ovarian …

 
 
 
 
 
 

Meta-analysis of remote ischemic conditioning in patients with acute myocardial infarction

 
 

Changfeng Man, Dandan Gong, Yongjing Zhou et al.

 
 

Effects of remote ischemic conditioning (RIC) in acute myocardial infarction (AMI) patients remain conflicting. We performed this meta-analysis of randomized clinical trials …

 
 
 
 
 
 

Aggravated myocardial infarction-induced cardiac remodeling and heart failure in histamine-deficient mice

 
 

Jinmiao Chen, Tao Hong, Suling Ding et al.

 
 

Histamine has pleiotropic pathophysiological effects, but its role in myocardial infarction (MI)-induced cardiac remodeling remains unclear. Histidine decarboxylase (HDC) is the …

 
 
 
 
 
 

The ligand-bound thyroid hormone receptor in macrophages ameliorates kidney injury via inhibition of nuclear factor-κB activities

 
 

Fumihiko Furuya, Toshihisa Ishii, Shogo Tamura et al.

 
 

In chronic kidney disease (CKD) patients, inflammation plays a pivotal role in the progression of renal fibrosis. Hypothyroidism is associated with an increased occurrence of …

 
 
 
 
 
 

PD-1 inhibitors increase the incidence and risk of pneumonitis in cancer patients in a dose-independent manner: a meta-analysis

 
 

Jiaying Wu, Dongsheng Hong, Xiangnan Zhang et al.

 
 

Therapies that targeted PD-1 have shown remarkable rates of durable clinical responses in patients with various tumor types. However, the extent and knowledge of pulmonary …

 
 
 
 
 
 

The effect of diurnal distribution of carbohydrates and fat on glycaemic control in humans: a randomized controlled trial

 
 

Katharina Kessler, Silke Hornemann, Klaus J. Petzke et al.

 
 

Diurnal carbohydrate and fat distribution modulates glycaemic control in rodents. In humans, the optimal timing of both macronutrients and its effects on glycaemic control after …

 
 
 
 
 
 

Excessive fruit consumption during the second trimester is associated with increased likelihood of gestational diabetes mellitus: a prospective study

 
 

Wu-Qing Huang, Ying Lu, Ming Xu et al.

 
 

This study aimed to investigate the association between fruit consumption during the second trimester and the occurrence of gestational diabetes mellitus (GDM). A prospective …

 
 
 
 
 
 

Eggshell membrane powder ameliorates intestinal inflammation by facilitating the restitution of epithelial injury and alleviating microbial dysbiosis

 
 

Huijuan Jia, Manaka Hanate, Wanping Aw et al.

 
 

Gut microbiota is an essential factor in the shaping of intestinal immune system development and driving inflammation in inflammatory bowel disease (IBD). We report the effects …

 
 
 
 
 
 

A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection

 
 

Paddy Ssentongo, Anna E. Robuccio, Godfrey Thuku et al.

 
 

One of the largest single sources of epilepsy in the world is produced as a neurological sequela in survivors of cerebral malaria. Nevertheless, the pathophysiological mechanisms …

 
 
 
 
 
 

Genetic analysis and clinical features of X-linked retinoschisis in Chinese patients

 
 

Qin-rui Hu, Lv-zhen Huang, Xiao-li Chen et al.

 
 

Many mutations in the retinoschisis (RS1) gene have been identified, but there are limited clinical data relating to the different genotypes. This study investigated the …

 
 
 
 
 
 

Long-term Effect of Radiotherapy in Rectal Cancer Patients with Mucinous Tumor: A Large Population Based Study

 
 

Xu Guan, Senhao Jia, Wei Chen et al.

 
 

Due to distinct biological behavior of mucinous adenocarcinoma (MAC) and signet ring cell cancer (SRC), the efficacy of radiotherapy on long-term outcome for rectal cancer (RC) …

 
 
 
 
 
 

Secreted Ectodomain of SIGLEC-9 and MCP-1 Synergistically Improve Acute Liver Failure in Rats by Altering Macrophage Polarity

 
 

Takanori Ito, Masatoshi Ishigami, Yoshihiro Matsushita et al.

 
 

Effective treatments for acute liver failure (ALF) are still lacking. We recently reported that a single intravenous administration of serum-free conditioned medium from stem …

 
 
 
 
 
 

Waist-hip Ratio (WHR), a Better Predictor for Prostate Cancer than Body Mass Index (BMI): Results from a Chinese Hospital-based Biopsy Cohort

 
 

Bo Tang, Cheng-Tao Han, Gui-Ming Zhang et al.

 
 

To investigate whether waist-hip ratio (WHR) is a better predictor of prostate cancer (PCa) incidence than body mass index (BMI) in Chinese men. Of consecutive patients who …

 
 
 
 
 
 

Nucleic acid-based polymers effective against hepatitis B Virus infection in patients don’t harbor immunostimulatory properties in primary isolated liver cells

 
 

Catherine Isabell Real, Melanie Werner, Andreas Paul et al.

 
 

Nucleic acid polymers (NAPs) block the release of subviral particles from hepatocytes, a mechanism consistent with their antiviral activity against hepatitis B virus (HBV) in …

 
 
 
 
 
 

Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome

 
 

Lance A. Johnson, Eileen Ruth S. Torres, Soren Impey et al.

 
 

Apolipoprotein E4 (E4) and type 2 diabetes are major risk factors for cognitive decline and late onset Alzheimer’s disease (AD). E4-associated phenotypes and insulin resistance …

 
 
 
 
 
 

Epidermal CD147 expression plays a key role in IL-22-induced psoriatic dermatitis

 
 

Cong Peng, ShengXi Zhang, Li Lei et al.

 
 

Psoriasis is a chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation and terminal differentiation. Interleukin-22 (IL-22) and the transcription …

 
 
 
 
 
 

Evidence from single nucleotide polymorphism analyses of ADVANCE study demonstrates EFNB3 as a hypertension risk gene

 
 

Johanne Tremblay, Yujia Wang, John Raelson et al.

 
 

EPH kinases and their ligands, ephrins (EFNs), have vital and diverse biological functions. We recently reported that Efnb3 gene deletion results in hypertension in female but …

 
 
 
 
 
 

Vesicle miR-195 derived from Endothelial Cells Inhibits Expression of Serotonin Transporter in Vessel Smooth Muscle Cells

 
 

Junzhong Gu, Huiyuan Zhang, Bingyang Ji et al.

 
 

Serotonin or 5-hydroxytryptamine (5-HT) has been shown to be essential in lots of physiological and pathological processes. It is well known that 5-HT and 5-HT transporter …

 
 
 
 
 
 

SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival

 
 

Beatrice Mohelnikova-Duchonova, Ondrej Strouhal, David J. Hughes et al.

 
 

Expression of the solute carrier (SLC) transporter SLC22A3 gene is associated with overall survival of pancreatic cancer patients. This study tested whether genetic variability …

 
 
 
 
 
 

(+)/(−)-Phaeocaulin A-D, four pairs of new enantiomeric germacrane-type sesquiterpenes from Curcuma phaeocaulis as natural nitric oxide inhibitors

 
 

Gui-yang Xia, De-juan Sun, Jiang-hao Ma et al.

 
 

Germacrane-type sesquiterpenes, with a flexible 10-membered ring unit as the structural and conformational features, play a central role in the biosynthesis and synthesis of …

 
 
 
 
 
 

Distribution Analysis via Mass Spectrometry Imaging of Ephedrine in the Lungs of Rats Orally Administered the Japanese Kampo Medicine Maoto

 
 

Takashi Matsumoto, Hirotaka Kushida, Shoko Matsushita et al.

 
 

Maoto, a traditional Japanese Kampo medicine, has been used to treat various respiratory diseases, including respiratory infections and influenza. Ephedrine (EPD), the main …

 
 
 
 
 
 

A millisecond micro-RNA separation technique by a hybrid structure of nanopillars and nanoslits

 
 

Qiong Wu, Noritada Kaji, Takao Yasui et al.

 
 

A millisecond micro-RNA separation of a mixture of total RNA and genomic DNA, extracted from cultured HeLa cells, was successfully achieved using a hybrid structure of …

 
 
 
 
 
 

Association between functional polymorphisms in the promoter of the miR-143/145 cluster and risk of intracranial aneurysm

 
 

Xiutian Sima, Hong Sun, Peizhi Zhou et al.

 
 

MicroRNAs (miRs)-143/145 are involved in various biological processes related to aneurysm formation and are downregulated in patients with intracranial aneurysm (IA). We aimed to …

 
 
 
 
 
 

Post-translational modifications in PrP expand the conformational diversity of prions in vivo

 
 

Patricia Aguilar-Calvo, Xiangzhu Xiao, Cyrus Bett et al.

 
 

Misfolded prion protein aggregates (PrPSc) show remarkable structural diversity and are associated with highly variable disease phenotypes. Similarly, other proteins, including …

 
 
 
 
 
 

Effects of different kinds of essentiality on sequence evolution of human testis proteins

 
 

Julia Schumacher, Hans Zischler, Holger Herlyn

 
 

We asked if essentiality for either fertility or viability differentially affects sequence evolution of human testis proteins. Based on murine knockout data, we classified a set …

 
 
 
 
 
 

Low-dose penicillin exposure in early life decreases Th17 and the susceptibility to DSS colitis in mice through gut microbiota modification

 
 

Shuang Jin, Di Zhao, Chenwen Cai et al.

 
 

Antibiotic exposure in early life can lead to a significant change of the gut microbiota and may contribute to later onset of inflammatory bowel disease (IBD). However, the …

 
 
 
 
 
 

Amigo2-upregulation in Tumour Cells Facilitates Their Attachment to Liver Endothelial Cells Resulting in Liver Metastases

 
 

Yusuke Kanda, Mitsuhiko Osaki, Kunishige Onuma et al.

 
 

Since liver metastasis is the main cause of death in cancer patients, we attempted to identify the driver gene involved. QRsP-11 fibrosarcoma cells were injected into the spleens …

 
 
 
 
 
 

Chemosensitivity of MCF-7 cells to eugenol: release of cytochrome-c and lactate dehydrogenase

 
 

Rana Al Wafai, Warde El-Rabih, Meghri Katerji et al.

 
 

Phytochemicals have been extensively researched for their potential anticancer effects. In previous study, direct exposure of rat liver mitochondria to eugenol main ingredient of …

 
 
 
 
 
 

Renal systolic time intervals derived from intra-renal artery Doppler as a novel predictor of adverse cardiac outcomes

 
 

Wen-Hsien Lee, Po-Chao Hsu, Chun-Yuan Chu et al.

 
 

The aim of this study was to evaluate the use of renal systolic time intervals measured by electrocardiographic gated Doppler ultrasonography for predicting adverse cardiac …

 
 
 
 
 
 

Body mass index trajectory patterns and changes in visceral fat and glucose metabolism before the onset of type 2 diabetes

 
 

Keisuke Kuwahara, Toru Honda, Tohru Nakagawa et al.

 
 

We investigated BMI trajectory patterns before diabetes diagnosis and examined associated changes in visceral adiposity and glucose metabolism. 23,978 non-diabetic Japanese …

 
 
 
 
 
 

Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte

 
 

Yu Sasaki, Teruo Hidaka, Takashi Ueno et al.

 
 

The irreversibility of glomerulosclerotic changes depends on the degree of podocyte injury. We have previously demonstrated the endocytic translocation of podocin to the …

 
 
 
 
 
 

Percutaneous Irreversible Electroporation: Long-term survival analysis of 71 patients with inoperable malignant hepatic tumors

 
 

C. Niessen, S. Thumann, L. Beyer et al.

 
 

Aim of this retrospective analysis was to evaluate the survival times after percutaneous irreversible electroporation (IRE) in inoperable liver tumors not amenable to thermal …

 
 
 
 
 
 

A reduced lymphocyte ratio as an early marker for predicting acute pancreatitis

 
 

Xiuzhong Qi, Fangyong Yang, Haitao Huang et al.

 
 

The early diagnosis and severity grading for acute pancreatitis (AP) are difficult to determine because of the complexity and differences in disease process. To date, few studies …

 
 
 
 
 
 

Treatment of rabbit growth plate injuries with oriented ECM scaffold and autologous BMSCs

 
 

Wenchao Li, Ruijiang Xu, Jiangxiang Huang et al.

 
 

Tissue-engineered technology has provided a promising method for the repair of growth plate injuries using biocompatible and biodegradable scaffolds and appropriate cells. The …

 
 
 
 
 
 

Utilization of a combined EEG/NIRS system to predict driver drowsiness

 
 

Thien Nguyen, Sangtae Ahn, Hyojung Jang et al.

 
 

The large number of automobile accidents due to driver drowsiness is a critical concern of many countries. To solve this problem, numerous methods of countermeasure have been …

 
 
 
 
 
 

A multi-component classifier for nonalcoholic fatty liver disease (NAFLD) based on genomic, proteomic, and phenomic data domains

 
 

G. Craig Wood, Xin Chu, George Argyropoulos et al.

 
 

Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of conditions that include steatohepatitis and fibrosis that are thought to emanate from hepatic steatosis. Few …

 
 
 
 
 
 

Incidence and risk factors of retreatment after three-monthly aflibercept therapy for exudative age-related macular degeneration

 
 

Wataru Kikushima, Yoichi Sakurada, Seigo Yoneyama et al.

 
 

Though anti-vascular endothelial growth factor therapy has become the standard treatment for exudative age-related macular degeneration (AMD), retreatment after the initial …

 
 
 
 
 
 

Interferon regulatory factor-1 activates autophagy to aggravate hepatic ischemia-reperfusion injury via the P38/P62 pathway in mice

 
 

Yao Yu, Shipeng Li, Zhen Wang et al.

 
 

Increasing evidence has linked autophagy to a detrimental role in hepatic ischemia- reperfusion (IR) injury (IRI). Here we focus on the role of interferon regulatory factor-1 …

 
 
 
 
 
 

Gd-EOB-DTPA-enhanced MRI for evaluation of liver function: Comparison between signal-intensity-based indices and T1 relaxometry

 
 

Michael Haimerl, Niklas Verloh, Florian Zeman et al.

 
 

Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a paramagnetic hepatobiliary magnetic resonance (MR) contrast agent. Due to its OATP1B1/B3-dependent …

 
 
 
 
 
 

A cluster of Zika virus infection in a Chinese tour group returning from Fiji and Samoa

 
 

Jimin Sun, Tao Fu, Haiyan Mao et al.

 
 

Zika virus is currently causing extensive outbreaks in a number of countries in South and Central America and the Caribbean and has been associated with foetal abnormalities. We …

 
 
 
 
 
 

Improved Bioavailability and Antitumor Effect of Docetaxel by TPGS Modified Proniosomes: In Vitro and In Vivo Evaluations

 
 

Helong Liu, Liangxing Tu, Yongxin Zhou et al.

 
 

A novel oral drug delivery system, TPGS modified docetaxel proniosomes (DTX-TPGS-PNs), was designed to enhance the oral bioavailability and antitumor efficiency of the poorly …

 
 
 
 
 
 

Integrative Diffusion-Weighted Imaging and Radiogenomic Network Analysis of Glioblastoma multiforme

 
 

Dieter Henrik Heiland, Carl Philipp Simon-Gabriel, Theo Demerath et al.

 
 

In the past, changes of the Apparent Diffusion Coefficient in glioblastoma multiforme have been shown to be related to specific genes and described as being associated with …

 
 
 
 
 
 

Cluster analysis: a new approach for identification of underlying risk factors for coronary artery disease in essential hypertensive patients

 
 

Qi Guo, Xiaoni Lu, Ya Gao et al.

 
 

Grading of essential hypertension according to blood pressure (BP) level may not adequately reflect clinical heterogeneity of hypertensive patients. This study was carried out to …

 
 
 
 
 
 

Profiling analysis of long non-coding RNAs in early postnatal mouse hearts

 
 

Xiongshan Sun, Qi Han, Hongqin Luo et al.

 
 

Mammalian cardiomyocytes undergo a critical hyperplastic-to-hypertrophic growth transition at early postnatal age, which is important in establishing normal physiological …

 
 
 
 
 
 

Surveillance strategies for Classical Swine Fever in wild boar – a comprehensive evaluation study to ensure powerful surveillance

 
 

Katja Schulz, Marisa Peyre, Christoph Staubach et al.

 
 

Surveillance of Classical Swine Fever (CSF) should not only focus on livestock, but must also include wild boar. To prevent disease transmission into commercial pig herds, it is …

 
 
 
 
 
 

Bioinformatics analysis of the proteins interacting with LASP-1 and their association with HBV-related hepatocellular carcinoma

 
 

Fan-Yun Kong, Ting Zhu, Nan Li et al.

 
 

LIM and SH3 domain protein (LASP-1) is responsible for the development of several types of human cancers via the interaction with other proteins; however, the precise biological …

 
 
 
 
 
 

Sequential activation of different pathway networks in ischemia-affected and non-affected myocardium, inducing intrinsic remote conditioning to prevent left ventricular remodeling

 
 

Noemi Pavo, Dominika Lukovic, Katrin Zlabinger et al.

 
 

We have analyzed the pathway networks of ischemia-affected and remote myocardial areas after repetitive ischemia/reperfusion (r-I/R) injury without ensuing myocardial infarction …

 
 
 
 
 
 

Inhibition of PHD3 by salidroside promotes neovascularization through cell–cell communications mediated by muscle-secreted angiogenic factors

 
 

Jing Zhang, Vivi Kasim, Yu-Dan Xie et al.

 
 

Therapeutic angiogenesis has been considered as a potential strategy for treating peripheral artery diseases including hind-limb ischemia (HLI); however, no effective drug-based …

 
 
 
 
 
 

Polymorphisms and Pharmacogenomics for the Clinical Efficacy of Methotrexate in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis

 
 

Qi Qiu, Jing Huang, Xiaoming Shu et al.

 
 

Methotrexate (MTX) is widely used and considered a first-line disease modifying anti-rheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA). Many of the relevant …

 
 
 
 
 
 

Altered Topological Properties of Brain Networks in Social Anxiety Disorder: A Resting-state Functional MRI Study

 
 

Hongru Zhu, Changjian Qiu, Yajing Meng et al.

 
 

Recent studies involving connectome analysis including graph theory have yielded potential biomarkers for mental disorders. In this study, we aimed to investigate the differences …

 
 
 
 
 
 

Influence of the Valsalva maneuver on cardiac hemodynamics and right to left shunt in patients with patent foramen ovale

 
 

Enfa Zhao, Yafei Zhang, Chunmiao Kang et al.

 
 

The purpose of this study was to investigate the influence of the Valsalva maneuver (VM) on cardiac hemodynamics in patients with patent foramen ovale (PFO). Sixty-five patients …

 
 
 
 
 
 

Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles

 
 

Jung-Min Shin, Dae-Kyoung Choi, Kyung-Cheol Sohn et al.

 
 

Alopecia areata (AA), a chronic, relapsing, hair-loss disorder, is considered to be a T cell-mediated autoimmune disease. It affects approximately 1.7% of the population, but its …

 
 
 
 
 
 

D-Glutamate is metabolized in the heart mitochondria

 
 

Makoto Ariyoshi, Masumi Katane, Kenji Hamase et al.

 
 

D-Amino acids are enantiomers of L-amino acids and have recently been recognized as biomarkers and bioactive substances in mammals, including humans. In the present study, we …

 
 
 
 
 
 

Monitoring of dynamic changes in Keyhole Limpet Hemocyanin (KLH)-specific B cells in KLH-vaccinated cancer patients

 
 

Florian Wimmers, Nienke de Haas, Anja Scholzen et al.

 
 

Keyhole limpet hemocyanin (KLH) is used as an immunogenic neo-antigen for various clinical applications and during vaccine development. For advanced monitoring of KLH-based …

 
 
 
 
 
 

Intact sensory-motor network structure and function in far from onset premanifest Huntington’s disease

 
 

Martin Gorges, Hans-Peter Müller, Isabella Maria Sophie Mayer et al.

 
 

Structural and functional changes attributable to the neurodegenerative process in Huntington’s disease (HD) may be evident in HTT CAG repeat expansion carriers before the …

 
 
 
 
 
 

Absence of PD-L1 on tumor cells is associated with reduced MHC I expression and PD-L1 expression increases in recurrent serous ovarian cancer

 
 

Stefanie Aust, Sophie Felix, Katharina Auer et al.

 
 

Immune-evasion and immune checkpoints are promising new therapeutic targets for several cancer entities. In ovarian cancer, the clinical role of programmed cell death receptor …

 
 
 
 
 
 

Comparative evaluation of leukocyte- and platelet-rich plasma and pure platelet-rich plasma for cartilage regeneration

 
 

Zhengliang Xu, Wenjing Yin, Yuelei Zhang et al.

 
 

Platelet-rich plasma (PRP) has gained growing popularity in the treatment of articular cartilage lesions in the last decade. However, the potential harmful effects of leukocytes …

 
 
 
 
 
 

3D characterization of morphological changes in the intervertebral disc and endplate during aging: A propagation phase contrast synchrotron micro-tomography study

 
 

Yong Cao, Shenghui Liao, Hao Zeng et al.

 
 

A better understanding of functional changes in the intervertebral disc (IVD) and interaction with endplate is essential to elucidate the pathogenesis of IVD degeneration disease …

 
 
 
 
 
 

Functional MRI in Awake Dogs Predicts Suitability for Assistance Work

 
 

Gregory S. Berns, Andrew M. Brooks, Mark Spivak et al.

 
 

The overall goal of this work was to measure the efficacy of fMRI for predicting whether a dog would be a successful service dog. The training and imaging were performed in 49 …

 
 
 
 
 
 

Suppression of cognitive function in hyperthermia; From the viewpoint of executive and inhibitive cognitive processing

 
 

Manabu Shibasaki, Mari Namba, Misaki Oshiro et al.

 
 

Climate change has had a widespread impact on humans and natural systems. Heat stroke is a life-threatening condition in severe environments. The execution or inhibition of …

 
 
 
 
 
 

Evaluation of dynamic changes in interstitial fluid proteome following microdialysis probe insertion trauma in trapezius muscle of healthy women

 
 

Maria V. Turkina, Nazdar Ghafouri, Björn Gerdle et al.

 
 

Microdialysis (MD) has been shown to be a promising technique for sampling of biomarkers. Implantation of MD probe causes an acute tissue trauma and provokes innate response …

 
 
 
 
 
 

Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos

 
 

Jean-Baptiste Fini, Bilal B. Mughal, Sébastien Le Mével et al.

 
 

Thyroid hormones are essential for normal brain development in vertebrates. In humans, abnormal maternal thyroid hormone levels during early pregnancy are associated with …

 
 
 
 
 
 

Experimental Evaluation of Kidney Regeneration by Organ Scaffold Recellularization

 
 

Andrea Remuzzi, Marina Figliuzzi, Barbara Bonandrini et al.

 
 

The rising number of patients needing renal replacement therapy, alongside the significant clinical and economic limitations of current therapies, creates an imperative need for …

 
 
 
 
 
 

Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver

 
 

Julia Volckmar, Marcus Gereke, Thomas Ebensen et al.

 
 

Hepatotropic viruses such as hepatitis C virus cause life-threatening chronic liver infections in millions of people worldwide. Targeted in vivo antigen-delivery to …

 
 
 
 
 
 

A peptide vaccine targeting angiotensin II attenuates the cardiac dysfunction induced by myocardial infarction

 
 

Ryo Watanabe, Jun-ichi Suzuki, Kouji Wakayama et al.

 
 

A peptide vaccine targeting angiotensin II (Ang II) was recently developed as a novel treatment for hypertension to resolve the problem of noncompliance with pharmacotherapy. Ang …

 
 
 
 
 
 

ZYZ-168 alleviates cardiac fibrosis after myocardial infarction through inhibition of ERK1/2-dependent ROCK1 activation

 
 

Shanshan Luo, Tran Ba Hieu, Fenfen Ma et al.

 
 

Selective treatments for myocardial infarction (MI) induced cardiac fibrosis are lacking. In this study, we focus on the therapeutic potential of a synthetic cardio-protective …

 
 
 
 
 
 

Autaptic Connections Shift Network Excitability and Bursting

 
 

Laura Wiles, Shi Gu, Fabio Pasqualetti et al.

 
 

We examine the role of structural autapses, when a neuron synapses onto itself, in driving network-wide bursting behavior. Using a simple spiking model of neuronal activity, we …

 
 
 
 
 
 

ELF-MF exposure affects the robustness of epigenetic programming during granulopoiesis

 
 

Melissa Manser, Mohamad R. Abdul Sater, Christoph D. Schmid et al.

 
 

Extremely-low-frequency magnetic fields (ELF-MF) have been classified as “possibly carcinogenic” to humans on the grounds of an epidemiological association of ELF-MF exposure …

 
 
 
 
 
 

Preclinical evaluation of multi antigenic HCV DNA vaccine for the prevention of Hepatitis C virus infection

 
 

Hyojin Lee, Moonsup Jeong, Jooyeon Oh et al.

 
 

Direct-acting antiviral treatment for hepatitis C virus (HCV) infection is costly and does not protect from re-infection. For human and chimpanzees, recovery from acute HCV …

 
 
 
 
 
 

Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity

 
 

Gregory A. Raciti, Rosa Spinelli, Antonella Desiderio et al.

 
 

Epigenetic modifications alter transcriptional activity and contribute to the effects of environment on the individual risk of obesity and Type 2 Diabetes (T2D). Here, we have …

 
 
 
 
 
 

Bifidobacterium breve with α-linolenic acid alters the composition, distribution and transcription factor activity associated with metabolism and absorption of fat

 
 

Elaine Patterson, Rebecca Wall, Sara Lisai et al.

 
 

This study focused on the mechanisms that fatty acid conjugating strains - Bifidobacterium breve NCIMB 702258 and Bifidobacterium breve DPC 6330 - influence lipid metabolism when …

 
 
 
 
 
 
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