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Nature Reviews Molecular Cell Biology contents April 2017 Volume 18 Number 4 pp 211-273

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Nature Reviews Molecular Cell Biology


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TABLE OF CONTENTS
 
April 2017 Volume 18 Number 4
Nature Reviews Molecular Cell Biology cover

2015 2-year Impact Factor 38.602 Journal Metrics 2-year Median 30

In this issue
Research Highlights
Reviews

Also this month
 Featured article:
RNA-based recognition and targeting: sowing the seeds of specificity
Stanislaw A. Gorski, Jörg Vogel & Jennifer A. Doudna
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RESEARCH HIGHLIGHTSTop

Stem cells: Self-consumption will keep your blood young
p211 | doi:10.1038/nrm.2017.19
Autophagy is shown to restrict metabolic activation of adult haematopoietic stem cells, thereby contributing to the maintenance of their quiescence and stem cell potential throughout life.
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Non-coding RNA: The cancer link(RNA) between PIP3 and AKT
p212 | doi:10.1038/nrm.2017.18
The specific binding of the lincRNA LINK-A tothe phospholipid PIP3 and the kinase AKT activates AKT and promotes tumorigenesis and resistance to AKT inhibitors.
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In the news
p212 | doi:10.1038/nrm.2017.23
Co-culturing embryonic stem cells and trophoblast stem cells in a 3D scaffold recreates early steps of mouse embryogenesis.
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Epigenetics: DNA methylation prevents intragenic transcription
p212 | doi:10.1038/nrm.2017.25
DNA methylation by DNMT3B within the bodies of genes prevents aberrant transcription initiation.
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JOURNAL CLUB
Unclogging sickle cell anaemia

p214 | doi:10.1038/nrm.2017.17
Li and Lodish describe how a shift in our understanding of the molecular basis of sickle cell anaemia has led to clinical success.
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Protein metabolism: Counteracting toxic protein aggregation
p214 | doi:10.1038/nrm.2017.24
Sirtuin 2 deacetylates the amino terminus of [alpha]-synuclein, thereby favouring its aggregation and toxicity associated with neurodegenerative diseases.
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IN BRIEF

Cell signalling: Notch under tension | Chromosome biology: Trimethylation of CENP-A supports mitotic fidelity | Membrane dynamics: PERKs of plasma membrane-ER communication
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REVIEWSTop
RNA-based recognition and targeting: sowing the seeds of specificity
Stanislaw A. Gorski, Jörg Vogel & Jennifer A. Doudna
p215 | doi:10.1038/nrm.2016.174
Insights into eukaryotic, bacterial and archaeal RNA-based regulatory systems, including microRNAs, small interfering RNAs, clustered regularly interspaced short palindromic repeats (CRISPR) RNA and small RNAs that are dependent on the RNA chaperone protein Hfq, have revealed that they achieve specificity using similar strategies. Specifically, the presentation of short 'seed sequences' within a ribonucleoprotein complex facilitates the search for and recognition of targets.
Abstract | Full Text | PDF
Mechanisms and functions of nuclear envelope remodelling
Rosemarie Ungricht & Ulrike Kutay
p229 | doi:10.1038/nrm.2016.153
The nuclear envelope is more than a static barrier between the nuclear and cytoplasmic compartments. It is very dynamic and undergoes extensive remodelling in response to mechanical challenges as well as during cell division, growth and differentiation.
Abstract | Full Text | PDF
Functions of bromodomain-containing proteins and their roles in homeostasis and cancer
Takao Fujisawa & Panagis Filippakopoulos
p246 | doi:10.1038/nrm.2016.143
Bromodomains (BRDs) are domains found in diverse proteins that recognize acetylated Lys residues, primarily on histones. Hence, BRD-containing proteins serve as readers of protein acetylation and engage in the regulation of gene expression. Recent studies have provided new insights into the physiological roles of BRD-containing proteins and their deregulation in cancer.
Abstract | Full Text | PDF | Supplementary information
The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain
Kevin M. Harlen & L. Stirling Churchman
p263 | doi:10.1038/nrm.2017.10
The carboxy-terminal domain (CTD) of RNA polymerase II is a repetitive and unstructured domain that is dynamically modified by post-translational modifications, which collectively constitute the 'CTD code'. Recent studies have revealed how CTD function is also promoted by phase separation in the presence of other low-complexity domains.
Abstract | Full Text | PDF
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