We bring you the latest news from the healthcare about the health care in the United Kingdom. Do your have news for us? Contact the editor. Watch also this special movie.

dinsdag 21 maart 2017

Nature Immunology Contents: April 2017 Volume 18 pp 365 - 474

If you are unable to see the message below, click here to view.
Nature Immunology


Advertisement
Nature Reviews Immunology and Nature Reviews Molecular Cell Biology: Poster on Bone marrow niches and HSC fates

This poster shows the signalling pathways between stromal and haematopoietic cells of the bone marrow niche that direct the fate of haematopoietic stem cells. 

Download

Produced with support from 
STEMCELL Technologies
TABLE OF CONTENTS

April 2017 Volume 18, Issue 4

News and Views
Research Highlights
Reviews
Articles
Resource
Corrigenda
Errata


Subscribe
 
Facebook
 
RSS
 
Recommend to library
 
Twitter
 
Advertisement
Looking to recruit? Limited time offer from Naturejobs: 

Get a 20% discount on our Premium job posting package when you buy before March 31, 2017.

  • Reach a potential audience of 10.8 million users* via nature.com
  • Be seen first by candidates — your position will appear at the top of related searches for 60 days and be displayed prominently on the Naturejobs home page as Job of the Week.
  • Plus appear as 'Featured' in search results
Post a job now.

* Publisher data 2016
 
 

News and Views

Top

To B-1 or not to B-1   pp365 - 366
Henry H Wortis
doi:10.1038/ni.3715
The transcription factor Bhlhe41 determines the survival and repertoire of B-1a cells.

See also: Article by Kreslavsky et al.

Quantifying the shifting landscape of B cell immunodominance   pp367 - 368
Gordon A Dale, Jessica R Shartouny and Joshy Jacob
doi:10.1038/ni.3695
Antibodies to neutralizing epitopes on hemagglutinin exhibit reproducible dynamic immunodominance patterns over time. Early responses target largely the Cb site, followed by Sb dominance and a concomitant rise in the diversity of neutralizing-antibody specificities.

See also: Article by Angeletti et al.

THEMIS-tery is solved   pp368 - 370
David L Wiest
doi:10.1038/ni.3708
THEMIS, the enigmatic regulator of T cell selection in the thymus, controls selection by oxidizing and suppressing the activity of the tyrosine phosphatase SHP-1.

See also: Article by Choi et al.

γδ T cells get adaptive   pp370 - 372
Bruno Silva-Santos and Jessica Strid
doi:10.1038/ni.3705
Throughout ontogeny, the γδ TCR repertoire in human blood becomes less diverse and more focused, yet is private in nature, and specific adult γδ T cell subsets undergo substantial clonal expansion after challenge with cytomegalovirus.

See also: Article by Ravens et al.

Immunology
JOBS of the week
Post-Doctoral Research Fellow, Statistical Methods Development
Fred Hutchinson Cancer Research Center
Experienced International Researcher
LE STUDIUM LOIRE VALLEY INSTITUTE FOR ADVANCED STUDIES
PostDoc Investigating Ladderane Lipid Biosynthesis
Max Planck Institute for Medical Research
Postdoctoral Fellow Vacancy - Interfacial Lab
King Abdullah University of Science and Technology (KAUST)
Senior Scientist Computational Toxicologist-Toxicokinetics
Philip Morris International (PMI)
More Science jobs from
Immunology
EVENT
NETTAB 2017 Methods, tools & platforms for Personalized Medicine in the Big Data Era
16.10.17
Palermo, Italy
More science events from

Research Highlights

Top

CD6 targeting | Maintaining TRM cells | Importing material | Atherosclerosis-prone HSCs | Antimicrobial IL-22 | Adipose-tissue ILCs

Reviews

Top

Mechanisms and consequences of Jak-STAT signaling in the immune system   pp374 - 384
Alejandro V Villarino, Yuka Kanno and John J O'Shea
doi:10.1038/ni.3691
O/'Shea and colleagues review recent advances in Jak–STAT biology, focusing on immune cell function, disease etiology and therapeutic intervention, as well as broader principles of gene regulation and signal-dependent transcription factors.

Ontogeny and homeostasis of CNS myeloid cells   pp385 - 392
Marco Prinz, Daniel Erny and Nora Hagemeyer
doi:10.1038/ni.3703
Microglia are by far the best-characterized macrophages in the CNS, but non-parenchymal populations, such as those found in the meninges, are being increasingly studied. Prinz et al. review the ontogeny and functions of both parenchymal macrophages and non-parenchymal macrophages the CNS.

Advertisement
An open access, online-only, multidisciplinary research journal dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.
 
Explore the benefits of submitting your next research article.
 

Articles

Top

Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection   pp393 - 401
Sarina Ravens, Christian Schultze-Florey, Solaiman Raha, Inga Sandrock, Melanie Drenker et al.
doi:10.1038/ni.3686
γδ T cells are generally understood to be innate lymphocytes. Prinz and colleagues show that human γδ T cells reconstituted after bone-marrow transplantation have a distinct repertoire that can be shaped by infection with cytomegalovirus, which suggests features of adaptive immunity.

See also: News and Views by Silva-Santos & Strid

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells   pp402 - 411
Andrew N Keller, Sidonia B G Eckle, Weijun Xu, Ligong Liu, Victoria A Hughes et al.
doi:10.1038/ni.3679
Mucosal-associated invariant T cells recognize vitamin-B-derived ligands presented via the major-histocompatibility-complex-like molecule MR1. Rossjohn and colleagues demonstrate that these cells recognize a wide variety of ligands, some derived from common drugs, in an agonist or antagonist manner.

Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation   pp412 - 421
Katarzyna Karwacz, Emily R Miraldi, Maria Pokrovskii, Asaf Madi, Nir Yosef et al.
doi:10.1038/ni.3683
Tr1 cells have potent regulatory effects in vitro and in vivo. Kuchroo and colleagues comprehensively describe the epigenetic, transcriptional and gene regulatory landscape that is essential for Tr1 cell differentiation.

Early transcriptional and epigenetic regulation of CD8+ T cell differentiation revealed by single-cell RNA sequencing   pp422 - 432
Boyko Kakaradov, Janilyn Arsenio, Christella E Widjaja, Zhaoren He, Stefan Aigner et al.
doi:10.1038/ni.3688
CD8+ T cells rapidly commence transcriptional changes after antigenic encounter and priming. Yeo and colleagues find substantial transcriptional heterogeneity among responding lymphocytes, particularly at the first division, that influences cell fate.

THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1   pp433 - 441
Seeyoung Choi, Claude Warzecha, Ekaterina Zvezdova, Jan Lee, Jérémy Argenty et al.
doi:10.1038/ni.3692
Love and colleagues show that THEMIS enhances the TCR signaling response to low-affinity ligands by inhibiting the tyrosine-phosphatase activity of SHP-1.

See also: News and Views by Wiest

Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells   pp442 - 455
Taras Kreslavsky, Bojan Vilagos, Hiromi Tagoh, Daniela Kostanova Poliakova, Tanja A Schwickert et al.
doi:10.1038/ni.3694
B-1a B cells are a distinct subset of mature B cells that provide innate-like protection against pathogens. Busslinger and colleagues identify the transcription factor Bhlhe41 as being essential for B-1a development and self-renewal.

See also: News and Views by Wortis

Defining B cell immunodominance to viruses   pp456 - 463
Davide Angeletti, James S Gibbs, Matthew Angel, Ivan Kosik, Heather D Hickman et al.
doi:10.1038/ni.3680
Antigenic epitopes differ in their immunogenicity. Yewdell and colleagues show that B cell and antibody responses to influenza A virus infection display reproducible dynamic immunodominance hierarchies to viral hemagglutinin epitopes.

See also: News and Views by Dale et al.

Advertisement
Online-only and open access, npj Primary Care Respiratory Medicine is the only fully-indexed scientific journal devoted to the management of respiratory diseases in primary care.

Explore the benefits of submitting your next research article.
 

Resource

Top

Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins   pp464 - 473
Raffael Nachbagauer, Angela Choi, Ariana Hirsh, Irina Margine, Sayaka Iida et al.
doi:10.1038/ni.3684
Antigenic drift and reassortment alters the epitopes of influenza virus. Krammer and colleagues reveal the cross-reactivity of antibody responses to viral hemagglutinin and neuraminidase in humans and several animal models, but the most prominent responses reflect 'original antigenic sin' to viral exposure.

Corrigenda

Top

Corrigendum: Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia   p474
Jing Fang, Lyndsey C Bolanos, Kwangmin Choi, Xiaona Liu, Susanne Christie et al.
doi:10.1038/ni0417-474a

Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells   p474
Sylvia Heink, Nir Yogev, Christoph Garbers, Marina Herwerth, Lilian Aly et al.
doi:10.1038/ni0417-474b

Errata

Top

Erratum: HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3   p474
Sonja I Gringhuis, Nina Hertoghs, Tanja M Kaptein, Esther M Zijlstra-Willems, Ramin Sarrami-Fooroshani et al.
doi:10.1038/ni0417-474c

Erratum: Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment   p474
Yohko Kitagawa, Naganari Ohkura, Yujiro Kidani, Alexis Vandenbon, Keiji Hirota et al.
doi:10.1038/ni0417-474d

Top
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com
More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount
(You will need to log in to be recognised as a nature.com registrant)

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our customer feedback department

Nature Publishing Group | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2017 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

nature publishing group