We bring you the latest news from the healthcare about the health care in the United Kingdom. Do your have news for us? Contact the editor. Watch also this special movie.

woensdag 1 maart 2017

EMBO reports Table of Contents for March 2017; Vol. 18, No. 3

March 2017 | Volume 18, Number 3 Submit


Table of Contents

Editorial
Opinion
Science & Society
Reviews
Scientific Report
Articles
COVER

Volume 18, Number 3



Editorial
Thumb

The recent executive order by US President Donald Trump to bar citizens from seven countries from entering the USA has a chilling effect on the free exchange of people and ideas in science.

Holger Breithaupt and Bernd Pulverer
Published online 08.02.2017

Opinion
Thumb

The authors propose a novel mechanism, termed Activity‐DEPendent Transpositon (ADEPT), in which epigenetic drift and the preferential use of homologous‐directed repair allows transposable elements to hijack activity‐induced double‐strand breaks in aged neurons, contributing to neurodegenerative disease.

Andrew G Newman, Paraskevi Bessa, Victor Tarabykin, and Prim B Singh
Published online 20.02.2017

Thumb

Many scientists who work abroad end up loosing out on pension rights in the home country. A pan‐European pension scheme could address this problem and support international mobility in research.

Vic Norris
Published online 31.01.2017

Science & Society
Thumb

Controversial decisions to ban athletes and the Russian doping scandal have raised doubts about the reliability of doping controls in professional sports. To ensure fairness and due process, doping tests must be transparent and adhere to the best scientific standards.

Erik Boye, Tore Skotland, Bjarne Østerud, and Jon Nissen‐Meyer
Published online 06.02.2017

Thumb

The Asilomar meeting on recombinant DNA technology and the Napa meeting on genome editing of the human germline are examples of self‐regulation by the scientific community. What can we learn from these cases to improve self‐regulation so as to ensure public trust and inform regulation of new technologies?

Daniel Gregorowius, Nikola Biller‐Andorno, and Anna Deplazes‐Zemp
Published online 20.02.2017

Thumb

Music unfolds over time and music perception has much to do with making temporal predictions. But how does the brain interpret upcoming auditory events, and why are humans better at it than most other animals?

Katrin Weigmann
Published online 26.01.2017

Thumb

For decades, biomimicry was a heralded concept of copying nature's inventions, but it yielded only few results. A recent shift towards more systematic ways to trawl nature's inventions and to understand their function before mimicking them could lead to new innovations.

Philip Hunter
Published online 13.02.2017

Reviews
Thumb

This review discusses the marriage of 3D organoid and genome engineering technologies, which holds great promise for biomedical research and translational application.

Jing Nie and Eri Hashino
Published online 15.02.2017

Thumb

Damaged and aggregated proteins accumulate during aging and increased proteotoxic stress. This review describes the spatial and temporal quality control systems that operate to limit toxicity and the inheritance of damage by succeeding cell generations.

Sandra Malmgren Hill, Sarah Hanzén, and Thomas Nyström
Published online 13.02.2017 Open Access

Scientific Report
Thumb

This study reveals the structural basis for how a single motif interacting with ubiquitin (MIU) at the C‐terminus of MINDY‐1 mediates selective binding to K48‐linked polyUb. Weak ubiquitin interactions from an adjacent MIU motif enhance binding to polyubiquitin.

Yosua Adi Kristariyanto, Syed Arif Abdul Rehman, Simone Weidlich, Axel Knebel, and Yogesh Kulathu
Published online 12.01.2017

Articles
Thumb

Human RIF1 protein forms a complex with PP1 that limits phosphorylation of MCM proteins to control S‐phase progression. RIF1‐PP1 also protects ORC1 from phosphorylation‐dependent degradation, to ensure full origin licensing in G1 phase.

Shin‐ichiro Hiraga, Tony Ly, Javier Garzón, Zuzana Hořejší, Yoshi‐nobu Ohkubo, Akinori Endo, Chikashi Obuse, Simon J Boulton, Angus I Lamond, and Anne D Donaldson
Published online 11.01.2017 Open Access

Thumb

Hippo signaling regulates tissue size and aberrations in the pathway can lead to cancer. This study identifies MARK family kinases as negative regulators of Hippo signaling by promoting the activity of YAP and TAZ via the inhibition of the Hippo kinase cascade.

Emad Heidary Arash, Ahmed Shiban, Siyuan Song, and Liliana Attisano
Published online 09.02.2017

Thumb

CIP2A promotes malignancy by inhibiting the tumor suppressor activity of the protein phosphatase PP2A. This study presents the first crystal structure of CIP2A and characterizes the structural requirements for the binding of CIP2A to the B56 subunits of PP2A.

Jiao Wang, Juha Okkeri, Karolina Pavic, Zhizhi Wang, Otto Kauko, Tuuli Halonen, Grzegorz Sarek, Päivi M Ojala, Zihe Rao, Wenqing Xu, and Jukka Westermarck
Published online 07.02.2017

Thumb

Mitochondrial pH flashes are matrix pH responses to drops in mitochondrial potential. This study shows that these mitopHlashes are not detectable in cristae and intermembrane space and require OPA1 independently of mitochondrial fusion.

Manon Rosselin, Jaime Santo‐Domingo, Flavien Bermont, Marta Giacomello, and Nicolas Demaurex
Published online 07.02.2017 Open Access

Thumb

This study identifies an incoherent type‐4 feed‐forward loop (I4‐FFL) consisting of jasmonate, PAD4, and EDS5 in Arabidopsis. This I4‐FFL ensures robust and tunable accumulation of salicylic acid during immune activation through flagellin sensing.

Akira Mine, Tatsuya Nobori, Maria C Salazar‐Rondon, Thomas M Winkelmüller, Shajahan Anver, Dieter Becker, and Kenichi Tsuda
Published online 09.01.2017

Thumb

In human, the initial steps of cytochrome c oxidase (CIV) assembly and their coordination with mitochondrial protein synthesis remain to be fully understood. This study characterizes the twin CX9C protein CMC1 function in CIV subunit 1 (COX1) biogenesis.

Myriam Bourens and Antoni Barrientos
Published online 12.01.2017

Thumb

The E3 ubiquitin ligase MARCH5 targets the mitophagy receptor FUNDC1 for degradation, which desensitizes mitochondrial clearance and fine‐tunes mitophagy under hypoxic stress.

Ziheng Chen, Lei Liu, Qi Cheng, Yanjun Li, Hao Wu, Weilin Zhang, Yueying Wang, Sheikh Arslan Sehgal, Sami Siraj, Xiaohui Wang, Jun Wang, Yushan Zhu, and Quan Chen
Published online 19.01.2017

 

Unsubscribe from or edit your subscription for this service.
Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A.
Copyright © 2017 by the European Molecular Biology Organisation.