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zaterdag 11 februari 2017

The Lancet: [Series] Disease and economic burdens of dengue

[Series] Disease and economic burdens of dengue
The burden of dengue is large and growing. More than half of the global population lives in areas with risk of dengue transmission. Uncertainty in burden estimates, however, challenges policy makers' ability to set priorities, allocate resources, and plan for interventions. In this report, the first in a Series on dengue, we explore the estimations of disease and economic burdens of dengue, and the major estimation challenges, limitations, and sources of uncertainty. We also reflect on opportunities to remedy these deficiencies.
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[Series] Prevention and control of dengue—the light at the end of the tunnel
Advances in the development of new dengue control tools, including vaccines and vector control, herald a new era of desperately needed dengue prevention and control. The burden of dengue has expanded for decades, and now affects more than 120 countries. Complex, large-scale global forces have and will continue to contribute to the expansion of dengue, including population growth, unplanned urbanisation, and suboptimal mosquito control in urban centres. Although no so-called magic bullets are available, there is new optimism following the first licensure of a dengue vaccine and other promising vaccine candidates, and the development of novel vector control interventions to help control dengue and other expanding mosquito-borne diseases such as Zika virus.
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[Series] Dengue: knowledge gaps, unmet needs, and research priorities
Dengue virus is a mosquito-borne pathogen that causes up to about 100 million cases of disease each year, placing a major public health, social, and economic burden on numerous low-income and middle-income countries. Major advances by investigators, vaccine developers, and affected communities are revealing new insights and enabling novel interventions and approaches to dengue prevention and control. Such research has highlighted further questions about both the basic understanding of dengue and efforts to develop new tools.
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[Comment] Challenges in fetal surveillance of pregnant women with Zika virus
In the past 2 years, the Zika virus epidemic has driven an unprecedented research effort, gathering an impressive set of experts and a large number of scientific publications to characterise a disease about which very little was previously known. The rapid spread, unanswered questions, and devastating neurological sequelae led WHO to declare a Public Health Emergency of International Concern (PHIC) as soon as there was a strong suspicion of the association of Zika virus infection with Guillain-Barré syndrome and severe fetal neurological disorders, particularly microcephaly.
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[Articles] Analysis of blood from Zika virus-infected fetuses: a prospective case series
Normalisation of amniotic fluid and fetal blood for Zika virus, as well as maternal blood and urine, shows the limitations of the performance of these investigations, due to the possibility of false negative results. Abnormal fetal blood needs to be investigated further to establish prognostic factors of severe Zika virus infections.
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