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woensdag 1 februari 2017

Nature Reviews Neurology - Table of Contents alert Volume 13 Issue 2

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Nature Reviews Neurology

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TABLE OF CONTENTS
 
February 2017 Volume 13 Number 2Advertisement

Nature Reviews Neurology cover
2015 2-year Impact Factor 18.418 Journal Metrics 2-year Median 13
In this issue
Research Highlights
Year in Review
Reviews
Perspectives

Also this month
 Featured article:
The psychosis spectrum in Parkinson disease
Dominic H. ffytche, Byron Creese, Marios Politis, K. Ray Chaudhuri, Daniel Weintraub, Clive Ballard & Dag Aarsland


 

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RESEARCH HIGHLIGHTS

Top

Alzheimer disease: Soluble TREM2 in CSF sheds light on microglial activation in AD
Published online: 13 January 2017
p65 | doi:10.1038/nrneurol.2016.203

PDF


Parkinson disease: Could gut microbiota influence severity of Parkinson disease?
Published online: 16 December 2016
p66 | doi:10.1038/nrneurol.2016.195

PDF


Neuroimmunology: Could antibodies cause psychosis?
Published online: 23 December 2016
p66 | doi:10.1038/nrneurol.2016.198

PDF


Motor neuron disease: Nusinersen potentially effective in SMA
Published online: 23 December 2016
p66 | doi:10.1038/nrneurol.2016.199

PDF



IN BRIEF

Migraine: Migraine is associated with increased risk of perioperative ischaemic stroke | Stroke: Thrombolytic removal of intraventricular haemorrhage does not improve outcomes | Motor neuron disease: Sparing of oligodendrocytes in a mouse model of spinal muscular atrophy | Peripheral neuropathies: Atypical Charcot-Marie-Tooth disease linked to sphingosine 1-phosphate lyase deficiency
PDF

Neurology
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YEAR IN REVIEW

Top
CNS Infections in 2016: 2016, the year of Zika virus
Diederik van de Beek & Matthijs C. Brouwer
Published online: 13 January 2017
p69 | doi:10.1038/nrneurol.2016.202
In 2016, the literature on neurological infections was, understandably, dominated by Zika virus. However, we should not overlook important publications on the treatment of cryptococcal and bacterial meningitis.
Full Text | PDF


Neuro-oncology in 2016: Advances in brain tumour classification and therapy
Matthias Preusser & Christine Marosi
Published online: 20 January 2017
p71 | doi:10.1038/nrneurol.2017.3
Brain tumours encompass a heterogeneous collection of neoplasms, traditionally classified by histopathological criteria. In 2016, the WHO published an updated classification that, for the first time, defines brain tumour types according to integrated histological and molecular parameters. Furthermore, clinical trial results were reported that inform therapeutic decision-making in diffuse gliomas.
Full Text | PDF


Multiple sclerosis in 2016: Immune-directed therapies in MS — efficacy and limitations
Bernhard Hemmer & Mark Mühlau
Published online: 20 January 2017
p72 | doi:10.1038/nrneurol.2017.2
In 2016, new highly active treatment options for relapsing-remitting multiple sclerosis (MS) emerged. At the same time, large clinical trials in progressive MS highlighted the limitations of immune-directed therapies, and called for new strategies to treat disease progression in MS.
Full Text | PDF


Alzheimer disease in 2016: Putting AD treatments and biomarkers to the test
Eric M. Reiman
Published online: 13 January 2017
p74 | doi:10.1038/nrneurol.2017.1
Investigational treatments to impede the progression of Alzheimer disease (AD) are being evaluated in clinical trials, and biomarkers to detect and track the disease are being developed and deployed. Recent findings underscore the importance of ongoing clinical trials and biomarker developments in the understanding, treatment and prevention of AD.
Full Text | PDF


Movement disorders in 2016: Progress in Parkinson disease and other movement disorders
Joseph Jankovic
Published online: 13 January 2017
p76 | doi:10.1038/nrneurol.2016.204
In the field of movement disorders, areas that have seen important advances in 2016 include the pathogenesis of Parkinson disease involving extra-CNS α-synuclein pathology, treatment of hyperkinetic disorders with novel dopamine-depleting drugs, and MRI-guided ultrasound surgery for the treatment of essential tremor.
Full Text | PDF


Stroke in 2016: Stroke is treatable, but prevention is the key
Ale Algra & Marieke J. H. Wermer
Published online: 20 January 2017
p78 | doi:10.1038/nrneurol.2017.4
The past 2 years have seen major breakthroughs in endovascular treatment for acute ischaemic stroke. As highlighted in 2016, we now need to refine the logistics for delivery of this treatment, including patient selection. We should not forget, however, that it is better to prevent strokes in the first place.
Full Text | PDF



 
REVIEWS

Top
The psychosis spectrum in Parkinson disease
Dominic H. ffytche et al.
Published online: 20 January 2017
p81 | doi:10.1038/nrneurol.2016.200
The publication of a consensus definition of Parkinson disease (PD) psychosis in 2007 led to a rapid expansion of literature focusing on clinical aspects, mechanisms and treatment. The authors review this literature and discuss the evolving view of PD psychosis, from distinct classes of symptoms to a continuum progressing over the course of PD.
Abstract | Full Text | PDF


Gene discovery in amyotrophic lateral sclerosis: implications for clinical management
Ammar Al-Chalabi, Leonard H. van den Berg & Jan Veldink
Published online: 16 December 2016
p96 | doi:10.1038/nrneurol.2016.182
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease predominantly affecting upper and lower motor neurons. Here, the authors outline previous and current efforts to characterize genes that are associated with ALS, and describe what is currently known about the genetic architecture of ALS.
Abstract | Full Text | PDF | Supplementary information


Treatment decisions in multiple sclerosis — insights from real-world observational studies
Maria Trojano et al.
Published online: 13 January 2017
p105 | doi:10.1038/nrneurol.2016.188
Real-world observational studies have the potential to answer questions about multiple sclerosis (MS) treatment that randomized controlled trials cannot. Trojano and colleagues discuss the pitfalls and necessary safeguards in observational studies, and the insights that such studies have provided into treatment decisions for patients with MS.
Abstract | Full Text | PDF



 
PERSPECTIVES

Top
SCIENCE AND SOCIETY
Precision medicine for disease modification in Parkinson disease
Alberto J. Espay, Patrik Brundin & Anthony E. Lang
Published online: 20 January 2017
p119 | doi:10.1038/nrneurol.2016.196
In this Perspectives article, Espay and colleagues argue that that the adoption of precision medicine in Parkinson disease will require a revision of biomarker development efforts, with the ultimate goal of testing putative disease-modifying interventions in well-defined disease subgroups.
Full Text | PDF


Erratum: Unruptured intracranial aneurysms: development, rupture and preventive management
Nima Etminan & Gabriel J. Rinkel
Published online: 01 February 2017
p126 | doi:10.1038/nrneurol.2017.14

Full Text | PDF

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