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woensdag 21 februari 2018

Decision: Suspended and revoked licences for manufacturers and wholesalers of medicines

Decision: Suspended and revoked licences for manufacturers and wholesalers of medicines
Public list of companies in the UK who have had their licence to manufacture or wholesale medicines revoked or suspended.
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Detailed guide: Blood: authorisations and safety reporting
Licences and regulations for organisations that handle human blood or blood products and reporting adverse incidents with blood through SABRE.
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Form: Blood bank compliance report template
Template for a blood bank compliance report and guidance on completing it.
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Form: Blood facility declaration form
Blood facility declaration form to be completed and returned to MHRA.
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News story: Batches of Ventolin Accuhaler and Seretide Accuhaler asthma inhalers recalled
Three specific lots of asthma inhalers are being recalled, including preventer and emergency relief inhalers.
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Regulation: Medical devices: UK notified bodies
UK notified bodies listed under medical device directives.
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What's new on DG Health & Food Safety Website update - 21/02/2018

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BBC Health: Partially paralysed man blinks to communicate

Partially paralysed man blinks to communicate
Simon Field might not be able to move but he can still communicate, by blinking.
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Tool 'names and shames' hidden drug trials
Institutions that fail to report the results of drug trials will be named on a new website.
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Review ordered into epilepsy drug, vaginal mesh and Primodos
The PM wants concerns over a pregnancy test, vaginal mesh implants and an epilepsy drug to be looked at.
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Red wine compound 'could help tooth decay and gum disease fight'
Polyphenols found in red wine helped fend off harmful bacteria in the mouth, a study finds.
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Boozy brain
What do we know about the risks of dementia from drinking alcohol?
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2 x Non-executive Directors, North West Boroughs NHS Foundation Trust

2 x Non-executive Directors, North West Boroughs NHS Foundation Trust
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Improvement update: January/February 2018
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Provider bulletin: 21 February 2018
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Specialist nurses set up group to improve care for germ cell cancer

Specialist nurses set up group to improve care for germ cell cancer
A small group of specialist nurses have been the driving force behind the creation of a new multi-disciplinary organisation dedicated to improving care for germ cell cancers that affect the testicles and the ovaries.
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Nursing associate drugs guidance aims to 'calm the waters'
A broader focus on the range of high risk medicines that nursing associates will be expected to give, rather than just controlled drugs, will "calm the waters" among the profession, according to senior nurses behind new guidance on medication.
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Wearable technology could aid condition monitoring
Patients with long-term conditions, such as diabetes, could one day benefit from new types of sensor technology that are being developed by UK researchers.
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Admin support role for nurses 'improves patient care'
Patient falls and pressure ulcers have been reduced since two hospital nurses successfully lobbied for an administrative assistant to be appointed to support them, they have told Nursing Times.
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'More to do' on mother and baby nutrition in Scotland
There is still more work to do to encourage women in Scotland to improve their health before they become pregnant, a major report on maternal and infant nutrition has indicated.
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Associates will be unable to administer drugs under PGDs
Nursing associates will not legally be able to give drugs under agreements, known as patient group directions (PGDs), that allow staff to administer medicines to patients without a prescription, senior nurses have stressed as they released guidance for the new role.
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British Journal of Cancer - Table of Contents alert Volume 118 Issue 4

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British Journal of Cancer

Volume 118, Issue 4 (April 2018)

In this issue
Clinical Studies
Translational Therapeutics
Molecular Diagnostics
Cellular & Molecular Biology
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Protein kinase D1: gatekeeper of the epithelial phenotype and key regulator of cancer metastasis?

Peter Storz

British Journal of Cancer 2018 118 :459 - 461; February 20, 2018; 10.1038/bjc.2018.1


Abstract | Full Text

Clinical Studies

Phase I dose-escalation study of copanlisib in combination with gemcitabine or cisplatin plus gemcitabine in patients with advanced cancer

R D Kim, S R Alberts, C Peña, I Genvresse, A Ajavon-Hartmann et al.

British Journal of Cancer 2018 118 :462 - 470; January 18, 2018; 10.1038/bjc.2017.428


Abstract | Full Text

Postmenopausal breast cancer and oestrogen associations with the IgA-coated and IgA-noncoated faecal microbiota

James J Goedert, Xing Hua, Agata Bielecka, Isao Okayasu, Ginger L Milne et al.

British Journal of Cancer 2018 118 :471 - 479; January 23, 2018; 10.1038/bjc.2017.435


Abstract | Full Text

Immune gene expression and response to chemotherapy in advanced breast cancer

Theodoros Foukakis, John Lövrot, Alexios Matikas, Ioannis Zerdes, Julie Lorent et al.

British Journal of Cancer 2018 118 :480 - 488; January 25, 2018; 10.1038/bjc.2017.446


Abstract | Full Text

Robot-assisted radical prostatectomy vs laparoscopic and open retropubic radical prostatectomy: functional outcomes 18 months after diagnosis from a national cohort study in England

Julie Nossiter, Arunan Sujenthiran, Susan C Charman, Paul J Cathcart, Ajay Aggarwal et al.

British Journal of Cancer 2018 118 :489 - 494; January 18, 2018; 10.1038/bjc.2017.454


Abstract | Full Text

Translational Therapeutics

Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeutic strategy in cutaneous melanoma

Chiao-En Wu, Arman Esfandiari, Yi-Hsuan Ho, Nan Wang, Ahmed Khairallah Mahdi et al.

British Journal of Cancer 2017 118 :495 - 508; December 12, 2017; 10.1038/bjc.2017.433


Abstract | Full Text

Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma

Hailong Ma, Shufang Jin, Wenyi Yang, Ge Zhou, Mei Zhao et al.

British Journal of Cancer 2018 118 :509 - 521; January 18, 2018; 10.1038/bjc.2017.442


Abstract | Full Text

H1/pHGFK1 nanoparticles exert anti-tumoural and radiosensitising effects by inhibition of MET in glioblastoma

Wenyan Zhang, Rui Duan, Jian Zhang, William K C Cheung, Xiaoge Gao et al.

British Journal of Cancer 2018 118 :522 - 533; January 18, 2018; 10.1038/bjc.2017.461


Abstract | Full Text

A novel Epstein–Barr virus-latent membrane protein-1-specific T-cell receptor for TCR gene therapy

Hyun-Il Cho, Un-Hee Kim, A-Ri Shin, Ji-Na Won, Hyun-Joo Lee et al.

British Journal of Cancer 2018 118 :534 - 545; January 23, 2018; 10.1038/bjc.2017.475


Abstract | Full Text

Molecular Diagnostics

Cadherin-1 and cadherin-3 cooperation determines the aggressiveness of pancreatic ductal adenocarcinoma

Carole Siret, Aurélie Dobric, Anna Martirosyan, Chloé Terciolo, Sébastien Germain et al.

British Journal of Cancer 2017 118 :546 - 557; November 21, 2017; 10.1038/bjc.2017.411


Abstract | Full Text

LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity

R G Morgan, E Mortensson, D N Legge, B Gupta, T J Collard et al.

British Journal of Cancer 2017 118 :558 - 565; November 16, 2017; 10.1038/bjc.2017.412


Abstract | Full Text

Inflammatory cytokine IL-8/CXCL8 promotes tumour escape from hepatocyte-induced dormancy

Ahmad S Khazali, Amanda M Clark & Alan Wells

British Journal of Cancer 2017 118 :566 - 576; November 23, 2017; 10.1038/bjc.2017.414


Abstract | Full Text

Tumour budding in oral squamous cell carcinoma: a meta-analysis

Alhadi Almangush, Matti Pirinen, Ilkka Heikkinen, Antti A Mäkitie, Tuula Salo et al.

British Journal of Cancer 2017 118 :577 - 586; November 30, 2017; 10.1038/bjc.2017.425


Abstract | Full Text

Cellular & Molecular Biology

Protein kinase D1 regulates subcellular localisation and metastatic function of metastasis-associated protein 1

Aditya Ganju, Subhash C Chauhan, Bilal Bin Hafeez, Kyle Doxtater, Manish K Tripathi et al.

British Journal of Cancer 2018 118 :587 - 599; February 20, 2018; 10.1038/bjc.2017.431


Abstract | Full Text


Domestic light at night and breast cancer risk: a prospective analysis of 105?000 UK women in the Generations Study

Louise E Johns, Michael E Jones, Minouk J Schoemaker, Emily McFadden, Alan Ashworth et al.

British Journal of Cancer 2018 118 :600 - 606; January 23, 2018; 10.1038/bjc.2017.359


Abstract | Full Text

Anthropometric measurements and survival after a prostate cancer diagnosis


British Journal of Cancer 2017 118 :607 - 610; December 12, 2017; 10.1038/bjc.2017.440


Abstract | Full Text

Aspirin use and ovarian cancer mortality in a Danish nationwide cohort study

Freija Verdoodt, Susanne K Kjaer, Christian Dehlendorff & Søren Friis

British Journal of Cancer 2018 118 :611 - 615; January 09, 2018; 10.1038/bjc.2017.449


Abstract | Full Text

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